This study aimed to predict the drying kinetics, energy utilization (E u ), energy utilization ratio (EUR), exergy loss, and exergy efficiency of quince slice in a hot air (HA) dryer using artificial neural networks and ANFIS. The experiments were performed at air temperatures of 50, 60, and 70°C and air velocities of 0.6, 1.2, and 1.8 m/s. The thermal parameters were determined using thermodynamic relations. Increasing air temperature and air velocity increased the effective moisture diffusivity (D eff ), E u , EUR, exergy efficiency, and exergy loss. The value of the D eff was varied from 4.19 × 10 -10 to 1.18 × 10 -9 m 2 /s. The highest value E u , EUR, and exergy loss and exergy efficiency were calculated 0.0694 kJ/s, 0.882, 0.044 kJ/s, and 0.879, respectively. Midilli et al. model, ANNs, and ANFIS model, with a determination coefficient (R 2 ) of .9992, .9993, and .9997, provided the best performance for predicting the moisture ratio of quince fruit. Also, the ANFIS model, in comparison with the artificial neural networks model, was better able to predict E u , EUR, exergy efficiency, and exergy loss, with R 2 of .9989, .9988, .9986, and .9978, respectively. K E Y W O R D S adaptive neuro-fuzzy inference system, artificial neural networks, drying, quince, thermodynamic parameters | 595 ABBASPOUR-GILANDEH Et AL.focusing on energy and exergy analysis is very important (Lingayat, Chandramohan, & Raju, 2018;Yogendrasasidhar & Setty, 2018).Şevik, Aktaş, Dolgun, Arslan, and Tuncer (2019) analyzed the exergy and energy in the process of drying mint and apple slices in a solar and solar-infrared. The results indicated that the loss of exergy and exergy efficiency increases by increasing the air temperature. Exergy efficiency for mint in solar dryer and solar-infrared was 69.35% and 59. 07%, respectively. Akpinar, Midilli, and Bicer (2006) analyzed the energy and exergy in pumpkin. They reported that the pumpkin dried within the time range of 5.66-12 hr with a loss of exergy from 0 to 1.165 kJ/s. The maximum exergy of the system input was 2.198 kJ/s. Also, with increased exergy loss, the energy used in the solar dryer increased. Karthikeyan and Murugavelh (2018) studied the energy and exergy required to dry turmeric in a mixed-mode forced convection solar tunnel dryer and concluded that the loss of exergy and energy utilization ratio and its efficiency was increased with increasing temperature.