Drying efficiency and particle movement in coating—Impact on particle agglomeration and yield

Synthesis and characterization of microcapsules containing Rubitherm®RT27 obtained by spray drying

“…The microcapsule particle size both in the collection vessel and drying chamber was typically smaller than 10 m, having the collector product an average particle size of 3.9 m according to the Motic Images Plus program while particles collected in the drying chamber appear to be bound together by melted polymer. The particle agglomeration in the chamber can be due to liquid polymer bridges that can be formed and solidified between two or more spray droplets [42]. As the sprayed polymer shell materials of LDPE and EVA are thermoplastics [43], taking into account that 110 • C is the inlet gas temperature which is close to the melting point of the LDPE ranging between 105 and 115 • C and really higher than that of EVA located from 85 to 90 • C (according to the manufacturer datasheet), these material can be found molten into the chamber bridging the microcapsules and promoting the agglomeration.…”

A Feasibility Study on Pellet Coating Using a High-Speed Quasi-continuous Coater

“…3c). This was probably attributed to their larger specific surface area which increased the likelihood of pellet-pellet collisions (11). The Agg values of the 1.40-2.00 mm and 2.00-2.80 mm pellet size fractions were however comparable.…”

DEM–CFD modeling of a fluidized bed spray granulator

“…The ) is a common device in the pharmaceutical industry used to coat tablets and smaller particles in the range 20-1000 mm (Wurster, 1966;Tang et al, 2008;Karlsson et al, 2009). It is described by Teunou and Poncelet (2002) as the most efficient batch fluid bed coating equipment.…”