Drying of a single droplet to investigate process–structure–function relationships: a review

Sadek, Céline; Schuck, Pierre; Fallourd, Yannick; Pradeau, Nicolas; Floch-Fouéré, Cécile Le; Jeantet, Romain

doi:10.1007/s13594-014-0186-1

Cited by 87 publications

(57 citation statements)

References 121 publications

(166 reference statements)

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“…The advantages and drawbacks of each parameter should be weighed in order to produce products with desirable characteristics. Such parameters should not be analyzed separately, but rather looked as a complex model, which as a whole contributes to the success of the spray-drying process [2,64]. The scalability and the cost-effectiveness of this manufacturing process in obtaining dried particles in submicron-tomicron scale favors an increasing variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.…”

Section: Refmentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

124

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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Section: Refmentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

124

View full text Add to dashboard Cite

show abstract

“…Depending on the chemical and physical properties of the solute and the external conditions, later on different surface instabilities occur such as buckling, invagination, delamination and cracks [25]. Sadek et al [26][27][28] investigated on the drying dynamics of pendant droplets made of the two main milk proteins, whey proteins and casein micelles. For that purpose, the concentrated protein solution drop was hanged to a micropatterned substrate and exposed to stressful conditions (relative humidity, RH, below 5%).…”

Section: Single Droplet Studies Of Dairy Particle Formationmentioning

confidence: 99%

“…Moreover, the mechanical properties of the final materials of proteins were characterized using microindentation testing by Sadek et al [27]. It was shown that the interface of micellar casein micelles reached an earlier sol-gel transition, followed by elastic and plastic regimes in which the shell distorted and buckled to form a final wrinkled particle.…”

Section: Single Droplet Studies Of Dairy Particle Formationmentioning

confidence: 99%

Drying colloidal systems: Laboratory models for a wide range of applications

et al. 2018

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Abstract. The drying of complex fluids provides a powerful insight into phenomena that take place on time and length scales not normally accessible. An important feature of complex fluids, colloidal dispersions and polymer solutions is their high sensitivity to weak external actions. Thus, the drying of complex fluids involves a large number of physical and chemical processes. The scope of this review is the capacity to tune such systems to reproduce and explore specific properties in a physics laboratory. A wide variety of systems are presented, ranging from functional coatings, food science, cosmetology, medical diagnostics and forensics to geophysics and art.

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“…Insolubility originates from heat instability of the system before or during drying and depends on the composition, pretreatment (homogenisation, pasteurisation, lecithination) characteristics of the concentrate (pH, solids content, viscosity), dryer parameters (nozzle design, inlet and outlet temperatures) and finally, the transport and storage conditions (Sadek et al, 2014;Schuck et al, 2016;Sharma, Jana, & Chavan, 2012). Lactose, native whey proteins and some inorganic salts are the only completely water soluble components in milk powder.…”

Section: Introductionmentioning

confidence: 99%

Formation and structure of insoluble particles in reconstituted model infant formula powders

Toikkanen

Outinen

Malafronte

et al. 2018

International Dairy Journal

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a b s t r a c tPhase separation of insoluble particles, so called "white flecks", is a physical defect in reconstituted milk obtained from spray-dried, fat-containing dairy powders. Compared with bulk powder particles, white flecks have quite different chemical and morphological characteristics. They consist mainly of proteins and fat, forming a dense network. Here, two concurrent formation mechanisms are suggested based on the structures revealed by confocal microscopy imaging. Fused spherical particles with free fat on the surface were the most abundant and likely formed during the manufacturing process. Sharp-edged particles containing shapes typical of lactose crystals formed during storage. Fat globule stability was thus determined to be critical in preventing white fleck formation. Stability was increased with (a) the presence of lecithin in the oil phase; (b) systems with high protein-to-fat ratio and (c) storage in dry conditions since humidity leads to lactose crystallisation and disruption of the fat globules in powders.

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Drying of a single droplet to investigate process–structure–function relationships: a review

Cited by 87 publications

References 121 publications

Spray Drying: An Overview

Spray Drying: An Overview

Drying colloidal systems: Laboratory models for a wide range of applications

Formation and structure of insoluble particles in reconstituted model infant formula powders

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