Drying of a single droplet of dextrin: Drying kinetics modeling and particle formation

Zaitone, Belal Al; Al-Zahrani, Abdulrahim A.; Al-Shahrani, Saad; Lamprecht, Alf

doi:10.1016/j.ijpharm.2019.118888

Cited by 20 publications

(15 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When applying temperatures above the boiling point of water, the evaporation was accelerated, the formation of a (thinner) crust took place even earlier and at larger droplet diameters, and a larger volume expansion during the inflation/deflation period led to a single big cavity [ 47 ]. The above described general temperature trends and dependencies are in line with studies on a broad selection of solutions: skimmed milk droplets on a glass filament, hydroxypropylated pea starch (HPS) on a polyamide wire, sucrose droplets on a glass filament, poly(lactide-co-glycolide) in ethyl acetate in an acoustic levitator, dextrin droplets in an acoustic levitator, and mannitol droplets on a glass filament [ 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Physics Of Particle Formation From a Drying Dropletsupporting

confidence: 61%

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

et al. 2020

View full text Add to dashboard Cite

Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.

show abstract

Section: Physics Of Particle Formation From a Drying Dropletsupporting

confidence: 61%

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The droplet position in the acoustic field will also change during evaporation. The relative vertical position of the center of the droplet is a function of its volume and weight, i.e., density 18, 36. The droplet vertical position profile is demonstrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Generally, the mass transfer rate of the solvent from the droplet can be expressed as 18:

true {\overset{\cdot}{m}}_{normalA} = A \frac{𝔇_{normalg} Sh}{D} (ρ_{As} - ρ_{\infty}) \frac{ρ}{(ρ - ρ_{As})}

…”

Section: Theoretical Method: Reaction Engineering Approachmentioning

confidence: 99%

“…Suspending a single droplet or particle in an ultrasonic levitator was implemented as a successful and well‐established experimental method to investigate the transport phenomena occurring on the surface of the droplet. The acoustic levitation method allows the tracking of a droplet shape throughout the drying process 18–21.…”

Section: Introductionmentioning

confidence: 99%

“…The moisture has to overcome an energy barrier in order to leave the droplet surface. The REA model has been implemented successfully by many researchers to model the drying kinetics of single droplets 16, 18, 26. The REA is capable of modeling the resistance to moisture migration both internally and externally.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spray Drying of Cellulose Nanofibers: Drying Kinetics Modeling of a Single Droplet and Particle Formation

Zaitone

Al-Zahrani

2021

Chem Eng & Technol

Self Cite

View full text Add to dashboard Cite

Microparticles embedded with cellulose nanofibers (CNFs) are produced via spray drying. The microdroplets are created in the spray dryer by atomization. The solvent evaporates from the droplet, and the dried particles are formed. The drying kinetics on the scale of one droplet is still not well understood. Drying of a single droplet CNF suspension was investigated in an acoustic levitator. The drying kinetics and morphology evolution during the drying process were obtained. The reaction engineering approach (REA) model provided a reasonable prediction of the drying kinetics. An absolute relative error of 2.5 % between the measured initial mass of the droplet and the REA model's estimated value was reported.

show abstract

Insights into bubble–droplet interactions in high-viscoelastic evaporating polymer droplets

Raghuram,

Roy,

Rao

et al. 2024

Exp Fluids

View full text Add to dashboard Cite

Drying of a single droplet of dextrin: Drying kinetics modeling and particle formation

Cited by 20 publications

References 51 publications

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

Spray Drying of Cellulose Nanofibers: Drying Kinetics Modeling of a Single Droplet and Particle Formation

Insights into bubble–droplet interactions in high-viscoelastic evaporating polymer droplets

Contact Info

Product

Resources

About