DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer

Lin, Shan‐Yang; Cheng, Wenli; Wei, Yen-Shan; Lin, Hong-Liang

doi:10.1038/pj.2011.15

Cited by 56 publications

(23 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 also show a characteristic difference between the lowest and the highest alginate producing strains at 1,730 cm −1 , although it is a weak absorption band. This band can be assigned to C0O carbonyl stretching [34][35][36], which has previously been observed in alginate [37,38] and has been related to alginate acetylation [39,40]. Thus, this reinforces the argument that PLSR is indeed detecting alginate production directly.…”

Section: Relationship Between Culture Growth and Alginate Biosynthesissupporting

confidence: 83%

Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression

et al. 2012

View full text Add to dashboard Cite

Alginate is an important medical and commercial product and currently is isolated from seaweeds. Certain microorganisms also produce alginate and these polymers have the potential to replace seaweed alginates in some applications, mainly because such production will allow much better and more reproducible control of critical qualitative polymer properties. The research conducted here presents the development of a new approach to this problem by analysing a transposon insertion mutant library constructed in an alginate-producing derivative of the Pseudomonas fluorescens strain SBW25. The procedure is based on the non-destructive and reagent-free method of Fourier transform infrared (FT-IR) spectroscopy which is used to generate a complex biochemical infrared fingerprint of the medium after bacterial growth. First, we investigate the potential differences caused by the growth media fructose and glycerol on the bacterial phenotype and alginate synthesis in 193 selected P. fluorescens mutants and show that clear phenotypic differences are observed in the infrared fingerprints. In order to quantify the level of the alginate we also report the construction and interpretation of multivariate partial least squares regression models which were able to quantify alginate levels successfully with typical normalized root-mean-square error in predictions of only approximately 14%. We have demonstrated that this high-throughput approach can be implemented in alginate screens and we believe that this FT-IR spectroscopic methodology, when combined with the most appropriate chemometrics, could easily be modified for the quantification of other valuable microbial products and play a valuable screening role for synthetic biology.

show abstract

Section: Relationship Between Culture Growth and Alginate Biosynthesissupporting

confidence: 83%

Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression

et al. 2012

View full text Add to dashboard Cite

show abstract

“…There were no alterations for both Povacoat and Soluplus before and after thermal treatment. Whereas the coprecipitate of IMC and NIC displayed a clear sharp endothermic peak at 126ºC (Figure 2A-i), which was close to the melting point at 128ºC of IMC-NIC co-crystals reported by our previous study and Kojima's report [33,56].…”

Section: Resultsmentioning

confidence: 75%

Effect of Povacoat or Soluplus on Solid-State Characterization of Indomethacin-Nicotinamide Co-Crystal Formation

Lin¹,

Lin²,

Hung³

et al. 2015

Pharm Anal Acta

View full text Add to dashboard Cite

Novel pharmaceutical polymers named Povacoat and Soluplus were used to investigate whether both polymers could influence the co-crystal formation between indomethacin (IMC) and nicotinamide (NIC) or the solid-state characterization of IMC-NIC mixture after co-grinding or solvent evaporation. Different weight ratios of Povacoat or Soluplus to IMC-NIC (molar ratio = 1:1) were respectively co-ground or dissolved in different solvents via ultrasonication, and then co-evaporated under a hood at ambient temperature. All the samples were determined by thermo analytical and FTIR spectroscopic studies. The results indicate that Povacoat or Soluplus added did not induce any interaction among Povacoat or Soluplus, IMC and NIC after co-grinding process. It is also found that Povacoat did not induce the IMC-NIC co-crystal formation but only caused the amorphous formation of IMC in the Povacoat/IMC-NIC evaporates prepared by 4:1 (w/w) weight ratio of Povacoat to IMC:NIC (1:1 molar ratio) with final volume ratio of 1:9 (v/v) water to ethanol via ultrasonication and evaporation. On the other hand, the Soluplus/IMC-NIC evaporates after co-evaporation from acetone solution exhibited either IMC-NIC co-crystal or amorphous IMC formation, which was dependent on the amounts of Soluplus added. The former IMC-NIC co-crystal was prepared in the formulations with less amount of Soluplus, implies that Soluplus did not interfere the IMC-NIC co-crystal formation after co-evaporation. While a large amount of Soluplus added might directly interrupt the IMC-NIC cocrystal formation but cause the amorphous IMC formed in the Soluplus solid dispersion.

show abstract

“…The absorption peaks appeared at ∼1640 and ∼1400 cm −1 is most probably, either due to C=C and C-C stretching, respectively, or from the symmetric and asymmetric stretching vibration of the C=O/C-O group. The absorption peaks appeared at ∼3000 cm −1 is due to the symmetric and asymmetric stretching vibration of CH 2 [29,30]. The absorption bands appeared at ∼1300 and ∼940 cm −1 was ascribed to symmetric C-H and bending vibration of -CH 3 group, respectively.…”

Section: Ft-ir Analysismentioning

confidence: 95%

“…The influence of pH of the solution (using pH value of 2, 4, 6, 8, 10, and 12) and amount of PVA-TMOP1 (using dosage value of 0.005, 0.01, 0.02, 0.04, 0.08, and 0.16 g) were optimized. The adsorption kinetics study was performed using the adsorbate-adsorbent contact time of 10,30,50,70,90,110,130, and 150 min. Furthermore, the adsorption isotherm test was conducted using MBD concentration of 1,5,10,15,20,25,30, and 35 mg l .…”

Section: Batch Adsorption Studiesmentioning

confidence: 99%

“…The adsorption kinetics study was performed using the adsorbate-adsorbent contact time of 10,30,50,70,90,110,130, and 150 min. Furthermore, the adsorption isotherm test was conducted using MBD concentration of 1,5,10,15,20,25,30, and 35 mg l . 1 For a proper understanding of the adsorption process, the adsorption isotherm models (equations (3)-(8)) and adsorption kinetics models (equations (9)-(13)) were used [21,22].…”

Section: Batch Adsorption Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Porous PVA/Zn–Fe–Mn oxide nanocomposites: methylene blue dye adsorption studies

Abebe

Murthy

Zereffa

et al. 2020

Mater. Res. Express

View full text Add to dashboard Cite

Adsorption is one of the noble techniques for remediation of organic and inorganic pollutants. The poly (vinyl alcohol) supported sol-gel and self-propagation routes have been used for the synthesis of porous ternary metal oxides nanocomposites. The optical, chemical bonding, crystallinity, morphological, textural, and electrochemical properties of the synthesized materials were characterized by DRS-UV-vis, FT-IR, XRD, SEM/EDX and TEM/HRTEM/SAED, BET, and CV/EIS techniques, respectively. The characterization of the nanocomposites confirmed their porous nature, high surface area, and better electrochemical properties. The synthesized nanomaterials were tested for the adsorption property of methylene blue dye. Important parameters such as the amount of PVA supported ternary metal oxide nanocomposite, pH of the solution, contact time, and concentration of methylene blue dye were optimized. For further understanding of the adsorption process, the adsorption isotherms and adsorption kinetics models were used. The adsorption tests revealed the presence of the chemisorption type of the adsorption process. several advantageous properties [8,9]. Besides, its hydroxyl groups on the carbon chain backbone act as a source for the formation of hydrogen bonding and enhances the formation of the nanocomposite [10]. As confirmed by various researchers [11][12][13][14][15][16], around 250, 300, 390, 400, and 400°C-500°C; the intramolecular decomposition, amorphous portion degradation, intermolecular breakdown, decaying of the crystalline portion of PVA, and formation of pure metal oxides had occurred, respectively.From methods used for the synthesis of inorganic nanomaterials/nanocomposites, the top-down and bottom-up approaches are common. Compared to the former, the latter is more popular and is considered as a promising route to control the growth, morphology, and properties of the nanomaterials. From the bottom-up chemical approaches; the hydrothermal, microemulsion, wet impregnation, sonochemical, ultrasonicmicrowave, electrochemical/electroless deposition, and spray-pyrolysis techniques are successfully applied. However, it is reported that these techniques follow special operating-conditions, long reaction time, lowthrough-put, and expensive procedure [17]. Therefore, it is essential to use effective and economically feasible methods such as sol-gel, precipitation, and impregnation. Furthermore, during the synthesis process, avoiding solvents that cause cancer and has mutagenic properties should also be taken into consideration [18].Considering all the mentioned aspects, this work was aimed to synthesize PVA supported ternary metal oxide nanocomposite (PVA-TMONC), using a simple and green sol-gel-self propagation technique. The methylene blue dye (MBD) adsorption efficiency of the synthesized PVA-TMONC was also tested. The physical properties of synthesized materials were characterized by critical analytical techniques. Using the Langmuir, Freundlich, Dubinin-Radushkevich (D-RK), Temkin, Flory-Huggins (FH), and Fowler-Gugge...

show abstract

DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer

Cited by 56 publications

References 17 publications

Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression

Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression

Effect of Povacoat or Soluplus on Solid-State Characterization of Indomethacin-Nicotinamide Co-Crystal Formation

Porous PVA/Zn–Fe–Mn oxide nanocomposites: methylene blue dye adsorption studies

Contact Info

Product

Resources

About