DTI metrics reflecting microstructural changes of normal appearing deep grey matter in multiple sclerosis

Homos, Mohamed D.; Ali, Mohamed T.; Nabil, Doaa Mohamed

doi:10.1016/j.ejrnm.2017.04.012

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…In a study by Homos et al [23] , the MD values of the thalamus, lentiform, and caudate nuclei were significantly higher in the MS group compared to normal individuals. Our results and Zhou et al [24] study revealed no significant change in MD of NAGM in the MS group compared to the healthy controls.…”

Section: Discussionmentioning

confidence: 86%

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Changes in diffusion tensor imaging indices in basal ganglia and thalamus of patients with Relapsing-Remitting Multiple Sclerosis and relation with clinical conditions: A case-control study

Amiri

Gerami

Shekarchi

et al. 2023

European Journal of Radiology Open

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Section: Discussionmentioning

confidence: 86%

“…However, FA changes in the thalamus in MS are controversial. Some studies have reported decreased FA in the thalamus of MS patients [27] , [28] while others showed increased FA values [3] , [23] , [29] , [30] .…”

Section: Discussionmentioning

confidence: 96%

Changes in diffusion tensor imaging indices in basal ganglia and thalamus of patients with Relapsing-Remitting Multiple Sclerosis and relation with clinical conditions: A case-control study

Amiri

Gerami

Shekarchi

et al. 2023

European Journal of Radiology Open

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“…Such axonal degeneration of more specific tracts can lead to widespread changes in WM and GM and in crossing fiber regions where one tract being degenerated can even lead to a regional increase in FA as when comparing the FA with the novel microscopic fractional anisotropy (microFA) metric which is unaffected by regional variations in orientation dispersion (60). Thus, a mixture of trauma-related mechanisms that have opposite effects on FA in thalamus and basal ganglia may also explain why FA is less sensitive to tissue damage in deep GM nuclei than MD (61).…”

Section: Discussionmentioning

confidence: 99%

Two Coarse Spatial Patterns of Altered Brain Microstructure Predict Post-traumatic Amnesia in the Subacute Stage of Severe Traumatic Brain Injury

et al. 2020

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Introduction: Diffuse traumatic axonal injury (TAI) is one of the key mechanisms leading to impaired consciousness after severe traumatic brain injury (TBI). In addition, preferential regional expression of TAI in the brain may also influence clinical outcome. Aim: We addressed the question whether the regional expression of microstructural changes as revealed by whole-brain diffusion tensor imaging (DTI) in the subacute stage after severe TBI may predict the duration of post-traumatic amnesia (PTA). Method: Fourteen patients underwent whole-brain DTI in the subacute stage after severe TBI. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for five bilateral brain regions: fronto-temporal, parieto-occipital, and midsagittal hemispheric white matter, as well as brainstem and basal ganglia. Region-specific calculation of mean FA and MD only considered voxels that showed no tissue damage, using an exclusive mask with all voxels that belonged to local brain lesions or microbleeds. Mean FA or MD of the five brain regions were entered in separate partial least squares (PLS) regression analyses to identify patterns of regional microstructural changes that account for inter-individual variations in PTA. Results: For FA, PLS analysis revealed two spatial patterns that significantly correlated with individual PTA. The lower the mean FA values in all five brain regions, the longer that PTA lasted. A pattern characterized by lower FA values in the deeper brain regions relative to the FA values in the hemispheric regions also correlated with longer PTA. Similar trends were found for MD, but opposite in sign. The spatial FA changes as revealed by PLS components predicted the duration of PTA. Individual PTA duration, as predicted Andreasen et al. Prediction of Post-traumatic Amnesia TBI by a leave-one-out cross-validation analysis, correlated with true PTA values (Spearman r = 0.68, p permutation = 0.008). Conclusion: Two coarse spatial patterns of microstructural damage, indexed as reduction in FA, were relevant to recovery of consciousness after TBI. One pattern expressed was consistent with diffuse microstructural damage across the entire brain. A second pattern was indicative of a preferential damage of deep midline brain structures.

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Impairments of white matter tracts and connectivity alterations in five cognitive networks of patients with multiple sclerosis

Lashkari

Davoodi‐Bojd

Fahmy

et al. 2021

Clinical Neurology and Neurosurgery

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DTI metrics reflecting microstructural changes of normal appearing deep grey matter in multiple sclerosis

Cited by 6 publications

References 32 publications

Changes in diffusion tensor imaging indices in basal ganglia and thalamus of patients with Relapsing-Remitting Multiple Sclerosis and relation with clinical conditions: A case-control study

Changes in diffusion tensor imaging indices in basal ganglia and thalamus of patients with Relapsing-Remitting Multiple Sclerosis and relation with clinical conditions: A case-control study

Two Coarse Spatial Patterns of Altered Brain Microstructure Predict Post-traumatic Amnesia in the Subacute Stage of Severe Traumatic Brain Injury

Impairments of white matter tracts and connectivity alterations in five cognitive networks of patients with multiple sclerosis

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