DTI Values in Key White Matter Tracts from Infancy through Adolescence

Cancelliere, Alessandro; Mangano, Francesco T.; Air, Ellen L.; Jones, Blaise V.; Altaye, Mekibib; Rajagopal, Amirtham; Holland, Scott K.; Hertzler, Dean A.; Yuan, Weihong

doi:10.3174/ajnr.a3350

Cited by 45 publications

(43 citation statements)

References 38 publications

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“…The FA value is closely related to the myelin integrity, nerve fiber density, and orientation. [10,23,24] In this study, we found that the FA values of ROIs before the ventriculoperitoneal shunt were substantially lower in the patients than the control group, which might reflect the demyelination of the white matter caused by enlarged ventricles and high intracranial pressure. [25,26] The FA values significantly increased in the patients after surgery, which might be due to the reduced intracranial pressure, improved CSF circulation, and restored myelination.…”

Section: Discussionmentioning

confidence: 83%

“…Diffusion tensor imaging (DTI) has been used to evaluate the changes in the brain structure, especially the integrity of the white matter. [10–12] It has been proven to be sensitive to quantify the white matter injury and damage recovery. [13,14] However, most of the studies have focused on the adult patients with normal intracranial pressure hydrocephalus, only very few studies have assessed the DTI changes in children with chronic hydrocephalus before and after surgery.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Zhao

Li²,

Cao

et al. 2016

Medicine

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To explore the use of diffusion tensor imaging (DTI) parameters in the quantitative assessment of early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus.Ten patients with communicating hydrocephalus (age: 2–36 months) and 14 age-/gender-matched controls (age: 2–36 months) were enrolled in this study. All patients underwent the ventriculoperitoneal shunt procedure. The imaging data were collected before and 3 months after the operation. Regions of interests (ROIs) included the white matter near the frontal horn of the lateral ventricles (FHLV), the occipital horn of the lateral ventricles (OHLV), occipital subcortical (OS) area, frontal subcortical (FS) area, and thalamus. Fractional anisotropies (FA) and apparent diffusion coefficients (ADC) of the ROIs before and after ventriculoperitoneal shunt were compared between the patients and the controls.Three months after surgery, the patients recovered from the surgery with ameliorated intracranial pressure and slight improvement of clinical intelligence scale and motor scale. Before ventriculoperitoneal shunt, the FA values (except the right FHLV) were significantly decreased and the ADC values were significantly increased in the patients with hydrocephalus, compared with the controls. After the ventriculoperitoneal shunt, the FA values in the FHLV and OHLV of the patients were similar to the controls, but the FA values in other ROIs were still significantly lower than controls. The ADC values in the FS and OS white matter areas of the patients were similar to the controls; however, the ADC values in other ROIs were still significantly higher in patients.The increase of FA and the reduction in ADC in the ROIs preceded the clinical function improvement in patients with high intracranial pressure hydrocephalus and reflected the early changes in brain tissue microstructure, such as the compression of the white matter areas in the ROIs.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Zhao

Li²,

Cao

et al. 2016

Medicine

View full text Add to dashboard Cite

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“…In particular, FA, a measure of local fiber organization, increases with age, from birth (Sadeghi et al, 2013) through late adolescence (Lebel et al, 2008) and beyond (Lebel et al, 2012; Tamnes et al, 2010a; Yeatman et al, 2014). Some studies report FA of the corpus callosum to be generally highest in early adolescence (Lebel et al, 2008), whereas others report later-occurring maxima in callosal FA (Asato et al, 2010; Hasan et al, 2009) and a posterior-to-anterior gradient of development (Asato et al, 2010; Cancelliere et al, 2013; Qiu et al, 2008). A fiber system showing continued development in adolescence is the superior longitudinal fasciculus (Peters et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study

et al. 2016

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Neurodevelopment continues through adolescence, with notable maturation of white matter tracts comprising regional fiber systems progressing at different rates. To identify factors that could contribute to regional differences in white matter microstructure development, large samples of youth spanning adolescence to young adulthood are essential to parse these factors. Recruitment of adequate samples generally relies on multi-site consortia but comes with the challenge of merging data acquired on different platforms. In the current study, diffusion tensor imaging (DTI) data were acquired on GE and Siemens systems through the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA), a multi-site study designed to track the trajectories of regional brain development during a time of high risk for initiating alcohol consumption. This cross-sectional analysis reports baseline Tract-Based Spatial Statistic (TBSS) of regional fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (L1), and radial diffusivity (LT) from the five consortium sites on 671 adolescents who met no/low alcohol or drug consumption criteria and 132 adolescents with a history of exceeding consumption criteria. Harmonization of DTI metrics across manufacturers entailed the use of human-phantom data, acquired multiple times on each of three non-NCANDA participants at each site’s MR system, to determine a manufacturer-specific correction factor. Application of the correction factor derived from human phantom data measured on MR systems from different manufacturers reduced the standard deviation of the DTI metrics for FA by almost a half, enabling harmonization of data that would have otherwise carried systematic error. Permutation testing supported the hypothesis of higher FA and lower diffusivity measures in older adolescents and indicated that, overall, the FA, MD, and L1 of the boys was higher than that of the girls, suggesting continued microstructural development notable in the boys. The contribution of demographic and clinical differences to DTI metrics was assessed with General Additive Models (GAM) testing for age, sex, and ethnicity differences in regional skeleton mean values. The results supported the primary study hypothesis that FA skeleton mean values in the no/low-drinking group were highest at different ages. When differences in intracranial volume were covaried, FA skeleton mean reached a maximum at younger ages in girls than boys and varied in magnitude with ethnicity. Our results, however, did not support the hypothesis that youth who exceeded exposure criteria would have lower FA or higher diffusivity measures than the no/low-drinking group; detecting the effects of excessive alcohol consumption during adolescence on DTI metrics may require longitudinal study.

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“…However, there have been far fewer studies on the development of pathways from birth to adult ages. A few studies (Cancelliere et al., 2013; Uda et al., 2015) investigated white matter pathways from infant to adult ages looking at growth curves of pathways, but without specifically studying the cerebellar pathways and without considering laterality.…”

Section: Introductionmentioning

confidence: 99%

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Levman

Lim

et al. 2016

Brain and Behavior

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IntroductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time‐course of cerebellar peduncle pathways in pediatric and young adult subjects.MethodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion‐weighted measurements with high‐angular resolution diffusion imaging (HARDI) tractography.ResultsQualitative and quantitative results were analyzed for age‐based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were identified in vivo with this technique: pathways between the rostral pons and inferior‐lateral cerebellum (MCP cog), associated predominantly with higher cognitive function, and pathways between the caudal pons and superior‐medial cerebellum (MCP mot), associated predominantly with motor function.DiscussionOur findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

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DTI Values in Key White Matter Tracts from Infancy through Adolescence

Cited by 45 publications

References 38 publications

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

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