Dual ATP/reduction-responsive polyplex to achieve the co-delivery of doxorubicin and miR-23b for the cancer treatment

Tang, Xiuhui; Liang, Xiao; Wen, Ke; Chen, Yingxuan; Han, Haobo; Li, Quanshun

doi:10.1016/j.colsurfb.2021.111955

Cited by 8 publications

(5 citation statements)

References 44 publications

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“…Tang et al recently developed a codelivery system of DOX and miR-23b which showed inhibition of proliferation and migration of lung cancer (A549) tumor cells. 194 Furthermore, reactive oxygen species (ROS) activable polyplexes have been shown to be promising for NIR-triggered synergistic cancer treatment. 195 This is shown in Figure 10.…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 89%

“…In addition to the previously mentioned characteristics, polyplexes are widely adopted due to their low immunogenicity compared to viral vectors, ease of manufacturing, and efficient transfection ability. Tang et al recently developed a codelivery system of DOX and miR-23b which showed inhibition of proliferation and migration of lung cancer (A549) tumor cells . Furthermore, reactive oxygen species (ROS) activable polyplexes have been shown to be promising for NIR-triggered synergistic cancer treatment .…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

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Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

209

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Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

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Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 89%

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

209

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“…Lipoic that contains disulfide bondsacid-modified oligoethylenimine (LA-OEI) was used as a carrier to deliver both DOX-Duplex and miR-23b. 126 The coadministered system induces cell cycle arrest in the S phase and suppresses cell proliferation by promoting apoptosis. Recently, lipid hybrid nanopolymers with a dual response to GSH/ROS modified with phenylborate ester and disulfide bonds have been newly reported.…”

Section: Molecularmentioning

confidence: 99%

“…DOX was loaded into the duplex to create the DOX-Duplex. Lipoic that contains disulfide bondsacid-modified oligoethylenimine (LA-OEI) was used as a carrier to deliver both DOX-Duplex and miR-23b . The coadministered system induces cell cycle arrest in the S phase and suppresses cell proliferation by promoting apoptosis.…”

Section: Tme-based Stimuli-responsive Rna Delivery Systemsmentioning

confidence: 99%

Tumor Microenvironment Responsive RNA Drug Delivery Systems: Intelligent Platforms for Sophisticated Release

Wang,

Zhang,

Lai

et al. 2024

Mol. Pharmaceutics

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Cancer is a significant health concern, increasingly showing insensitivity to traditional treatments, highlighting the urgent need for safer and more practical treatment options. Ribonucleic acid (RNA) gene therapy drugs have demonstrated promising potential in preclinical and clinical trials for antitumor therapy by regulating tumor-related gene expression. However, RNA's poor membrane permeability and stability restrict its effectiveness in entering and being utilized in cells. An appropriate delivery system is crucial for achieving targeted tumor effects. The tumor microenvironment (TME), characterized by acidity, hypoxia, enzyme overexpression, elevated glutathione (GSH) concentration, and excessive reactive oxygen species (ROS), is essential for tumor survival. Furthermore, these distinctive features can also be harnessed to develop intelligent drug delivery systems. Various nanocarriers that respond to the TME have been designed for RNA drug delivery, showing the advantages of tumor targeting and low toxicity. This Review discusses the abnormal changes of components in TME, therapeutic RNAs' roles, underlying mechanisms, and the latest developments in utilizing vectors that respond to microenvironments for treating tumors. We hope it provides insight into creating and optimizing RNA delivery vectors to improve their effectiveness.

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“…Furthermore, co‐delivery of DOX and miRNA‐23b by polyplexes reduces MMP‐9 expression to suppress migration and invasion of cancer cells. In response to intracellular ATP concentration and redox condition, DOX‐ and miRNA‐23b‐loaded polyplexes released DOX and suppressed tumor progression (Tang et al 2021). In another experiment, DOX‐ and miRNA‐34a‐loaded polyplexes were developed for suppressing growth and invasion of tumor cells.…”

Section: Nanobitoechnology In Doxorubicin Chemotherapymentioning

confidence: 99%

miRNAs as short non-coding RNAs in regulating doxorubicin resistance

Mirzaei,

Paskeh,

Moghadam

et al. 2023

J. Cell Commun. Signal.

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Dual ATP/reduction-responsive polyplex to achieve the co-delivery of doxorubicin and miR-23b for the cancer treatment

Cited by 8 publications

References 44 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Tumor Microenvironment Responsive RNA Drug Delivery Systems: Intelligent Platforms for Sophisticated Release

miRNAs as short non-coding RNAs in regulating doxorubicin resistance

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