Dual colorimetric and electrochemical sensing of organothiophosphorus pesticides by an azastilbene derivative

De, Chandrima; Samuels, Tova A.; Haywood, Tajay L.; Anderson, Ginger A.; Campbell, Keith; Fletcher, K. A.; Murray, Desmond H.; Obare, Sherine O.

doi:10.1016/j.tetlet.2010.01.100

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…A major advantage of mutimodal sensors is the minimization of false positives. With this in mind, we have recently developed and reported new chemosensors with multimodal sensing capabilities for analytes such as saccharides [ 54 ] and toxic OP compounds [ 55 ].…”

Section: Sensors With Multiple Modes Of Signal Transductionmentioning

confidence: 99%

“…We have shown that the azastilbene, dimethyl-[4-(2-quinolin-2-yl-vinyl)-phenyl]-amine (DQA), recognizes, reacts with and responds to the pesticides: ethion, malathion, parathion, and fenthion. DQA binding to either of the above mentioned pesticides resulted in changes of the UV-visible, fluorescence and cyclic voltammogram of DQA [ 55 ] indicating the selective binding. To synthesize donor-acceptor azastilbene chemosensors we relied upon the single step approach involving base-promoted condensation of donor-substituted aromatic aldehydes with methyl-substituted azaaromatics [ 56 – 58 ].…”

Section: Sensors With Multiple Modes Of Signal Transductionmentioning

confidence: 99%

“… Schematic representation of uncomplexed ( left ) and complexed ( right ) azastilbene [ 55 ]. (EDG = electron donating group).…”

Section: Figurementioning

confidence: 99%

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Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Obare

Guo

et al. 2010

Sensors

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131

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Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction.

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Section: Sensors With Multiple Modes Of Signal Transductionmentioning

confidence: 99%

Section: Sensors With Multiple Modes Of Signal Transductionmentioning

confidence: 99%

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Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Obare

Guo

et al. 2010

Sensors

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131

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“…More recently, electrochemical impedance spectroscopy (EIS) technique which provides high sensitivity has received tremendous attention in the field of sensor development [13][14][15]. Furthermore, sensors that incorporate simultaneous optical and electrochemical detection techniques allows for versatile detection of analytes thereby reducing the possibilities of false positives [16][17][18]. Therefore, the need for cost effective miniaturized devices that provide rapid, automated, and dual detection signals are paramount towards advancements in electro-optical sensor technology.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical impedance spectroscopy sensing of toxic organophosphorus compounds

et al. 2010

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Detection of toxic organophosphorus (OP) compounds using electrochemical and fluorescence spectroscopy is reported. A sensor device with gold (Au) interdigitated electrodes (IDT) on a glass substrate was used for the electrochemical detection of various OP compounds. Picomolar amounts of malathion, fenthion and ethion were detected by electrical impedance spectroscopy (EIS) using benzodipyrido[3,2-a:2'3'-c] phenazine (BDPPZ) as a sensor. Quantitative detection of malathion, fenthion and ethion, were also obtained via fluorescence spectroscopy for concentrations as low as 0.1 µM, 1 µM and 10 µM, respectively.

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“…Una ventaja importante de estos sensores multimodal es la minimización de falsos positivos. En este sentido, recientemente se han desarrollado y reportado nuevos sensores químicos con sensor multimodal con capacidades para analitos tales como sacáridos[157] y los compuestos OP tóxicos[158].Una nueva estrategia de diseño, utiliza y acopla la reactividad electrófila del átomo de fósforo pentavalente de los grupos fosforilo y tiofosforilo de los OPs tóxicos, a un fluoróforo nucleófilo capaz de reconocer e informar de las interacciones del sensor analito.En la señal la transducción se prevé que se produzca a través del sistema electrónico π del sistema aceptor donante (azastilbene) en la complejación del fósforo electrófilo con el sitio de unión nucleófilo que muestra el sensor químico óptico.Figura Nº16 Las estructuras químicas de los pesticidas analizados.Las estructuras químicas del etión, malatión, paratión y fentión, son las estructuras de los pesticidas OP por medio de los cuales se evalúa la eficacia de los sistemas aceptor donante azastilbenes, usado como sensores. Se ha demostrado que la azastilbene, dimetil-[4 -(2quinolin-2-il-vinil)-fenil]-amina (DQA), reconoce, reacciona y responde a los plaguicidas: etión, malatión, paratión y fentión.…”

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Formación y comportamiento de complejos de β-ciclodextrina con pesticidas y alcoholes

Coscarello¹

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En general, el propósito de este trabajo fue obtener conocimiento acerca de los complejos de β-ciclodextrina, estudiando la influencia de su presencia sobre las propiedades del huésped. Específicamente, en el caso de los plaguicidas este estudio ayudaría a evitar los efectos perjudiciales de los mismos, y además en el caso de alcoholes cíclicos predecir las diferencias estructurales de estos compuestos. Y en ambos, por último, contribuye a las investigaciones de los complejos originados por medio de macromoléculas.

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Dual colorimetric and electrochemical sensing of organothiophosphorus pesticides by an azastilbene derivative

Cited by 16 publications

References 18 publications

Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Electrochemical impedance spectroscopy sensing of toxic organophosphorus compounds

Formación y comportamiento de complejos de β-ciclodextrina con pesticidas y alcoholes

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