Dual cross-linked gellan gum/gelatin-based multifunctional nanocomposite hydrogel scaffold for full-thickness wound healing

Singh, Hemant; Yadav, Indu; Sheikh, Wajid Mohammad; Dan, Abhijit; Darban, Zenab; Shah, S. A.; Mishra, Narayan Chandra; Shahabuddin, Syed; Hassan, Shabir; Bashir, Showkeen Muzamil; Dhanka, Mukesh

doi:10.1016/j.ijbiomac.2023.126349

Cited by 18 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Determining the drug loading efficiency for the scaffolds is crucial in the field of drug delivery to optimize therapeutic effects, avoid toxic side effects, and minimize unwanted drug releases [46]. Therefore, the DEX loading efficiency was determined as 87.71%, 84.06%, 83.2%, and 82.69% for the fabricated bone scaffolds PCL/CS/DEX, PCL/CS/DEX/CPO1, PCL/CS/DEX/CPO2, and PCL/CS/DEX/CPO3, respectively.…”

Section: Drug Loading and Release Behaviourmentioning

confidence: 99%

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Vahora,

Singh,

Dan

et al. 2024

Biomed. Mater.

Self Cite

View full text Add to dashboard Cite

Maintaining the continuous oxygen supply and proper cell growth before blood vessel ingrowth at the bone defect site are considerably significant issues in bone regeneration. Oxygen-producing scaffolds can supply oxygen and avoid hypoxia leading to expedited bone regeneration. Herein, first oxygen-producing calcium peroxide nanoparticles (CPO NPs) are synthesized, and subsequently, the various amounts of synthesized CPO NPs (0.1, 0.5, and 1wt/v%) loaded in the scaffold composite, which is developed by simple physical blending of chitosan (CS) and polycaprolactone (PCL) polymers. To deliver the synergistic therapeutic effect, dexamethasone (DEX), known for its potential anti-inflammatory and osteogenic properties, is loaded into the nanocomposite scaffolds. The extensive physicochemical characterizations of nanocomposite scaffolds confirm the successful loading of CPO NPs, adequate porous morphology, pore size, hydrophilicity, and biodegradability. In vitro, biological studies support the antibacterial, hemocompatible, and cytocompatible (MG-63 and MC3T3-E1 cells) nature of the material when tested on respective cells. FE-SEM and Energy-dispersive X-ray spectroscopy confirm the successful biomineralization of the scaffolds. Scaffolds also exhibit the sustained release of DEX and efficient protein adsorption. This study revealed that a nanoengineered scaffold loaded with CPO NPs (PCL/CS/DEX/CPO 3) is a suitable candidate for bone tissue regeneration.

show abstract

Section: Drug Loading and Release Behaviourmentioning

confidence: 99%

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Vahora,

Singh,

Dan

et al. 2024

Biomed. Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…This approach was employed to improve localized bioavailability and achieve controlled delivery, with the ultimate goal of effectively addressing infectious chronic wounds. 111 Nanofibrous nanocomposite structure was developed by incorporating graphene nanosheets into electrospun gelatin/ chitosan matrices. 112 The introduction of graphene nanosheets significantly enhanced the porosity of the construct, reaching levels of up to 90% of their volume.…”

Section: Materials Advances Reviewmentioning

confidence: 99%

“…104 The clinical applicability of gelatin is limited due to its unfavorable mechanical integrity, inadequate in vivo performance, and unregulated active substance release. 111 To address these limitations for full-thickness wound healing, Singh et al engineered a dual cross-linked drug-loaded gelatin/gellan gum-based multifunctional nanocomposite hydrogel. The dually-crosslinked gelatin/gellan gum-based construct was utilized for the co-encapsulation of nanoceria and flurbiprofen (GG/Ge/NC-FLU).…”

Section: Bncs In Skin Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

See 1 more Smart Citation

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

Bal-Öztürk,

Alarçin,

Yaşayan

et al. 2024

Mater. Adv.

View full text Add to dashboard Cite

show abstract

Machine Learning Assisted Electronic/Ionic Skin Recognition of Thermal Stimuli and Mechanical Deformation for Soft Robots

Shi,

Lee,

Yang

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Soft robots have the advantage of adaptability and flexibility in various scenarios and tasks due to their inherent flexibility and mouldability, which makes them highly promising for real‐world applications. The development of electronic skin (E‐skin) perception systems is crucial for the advancement of soft robots. However, achieving both exteroceptive and proprioceptive capabilities in E‐skins, particularly in terms of decoupling and classifying sensing signals, remains a challenge. This study presents an E‐skin with mixed electronic and ionic conductivity that can simultaneously achieve exteroceptive and proprioceptive, based on the resistance response of conductive hydrogels. It is integrated with soft robots to enable state perception, with the sensed signals further decoded using the machine learning model of decision trees and random forest algorithms. The results demonstrate that the newly developed hydrogel sensing system can accurately predict attitude changes in soft robots when subjected to varying degrees of pressing, hot pressing, bending, twisting, and stretching. These findings that multifunctional hydrogels combine with machine learning to decode signals may serve as a basis for improving the sensing capabilities of intelligent soft robots in future advancements.

show abstract

Dual cross-linked gellan gum/gelatin-based multifunctional nanocomposite hydrogel scaffold for full-thickness wound healing

Cited by 18 publications

References 52 publications

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

Machine Learning Assisted Electronic/Ionic Skin Recognition of Thermal Stimuli and Mechanical Deformation for Soft Robots

Contact Info

Product

Resources

About