Dual crosslinked iminoboronate-chitosan hydrogels with strong antifungal activity against Candida planktonic yeasts and biofilms

Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs)

“…In one instance, rational engineering of a multifunctional material for actuation, shape memory, and self‐healing was realized by incorporation of a moisture‐insensitive polymer film for actuation, alginate for ionic control of shape memory, and boronic esters for self‐healing. Additional applications of DCCs in soft robotics may relate to coating materials, as boronic esters have been demonstrated in various self‐healing and dynamic surface coatings with antifungal, antioxidant, and antibacterial properties 101. Toward increasingly complex soft robotics, conductive graphene oxide (GO) nanocomposite hydrogel sensors might be incorporated for electrical inputs,102 and gas‐sensitive CANs may be utilized in future medical devices as biomimetics for similarly responsive tissues 103.…”

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

“…Three series of hydrogels based on chitosan and cinnamaldehyde were synthetized by imination reaction followed by the self-ordering of the newly formed imine units into clusters playing the role of chitosan crosslinkers. [8][9][10][11][12][13][14][15] Scheme 1 represents the obtaining of the studied hydrogels,…”

“…It is well documented in literature that the crosslinking degree strongly influences the morphology of the hydrogels. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]18 To see how this parameter influenced the morphology in the particular case of cinnamyl-imine-chitosan hydrogels, SEM images of the corresponding xerogels were acquired at high magnification. Representative images were given for the series L1-L4 ( Figure 2).…”

“…7 To surpass this problem, our group developed a new strategy to crosslink chitosan with monoaldehydes, based on the principles of dynamic covalent chemistry. [8][9][10][11][12][13][14][15] It was demonstrated that using this strategy, biocompatible hydrogels could be successfully obtained, because the method allows using a large variety of monoaldehyde crossslinkers. 9,10,15 One important feature of the hydrogels is their ability to absorb large amounts of water or biologic fluids, which prompt them to mimic the tissues, or to encapsulate large amounts of drug to create drug delivery systems.…”

Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

“…Let us note that this quantity with m 2 , where m is real. The first equality from (10) becomes the sine-Gordon equation of the fractal type: (12) A solution of this equation can be simply given if we assume that the quantities depend on x i through the linear form: (13) In this case, the equation (12) becomes: (14) where the accent notes the derivative after ξ and a 2 is the square of the vector a. Further, the equation (14) is multiplied with φ', after which it can be integrated and leads to: (15) where c is an integration constant that we assume real.…”