Dual-crosslinked nanocomposite hydrogels based on quaternized chitosan and clindamycin-loaded hyperbranched nanoparticles for potential antibacterial applications

Wei, Shibo; Liu, Xiang; Zhou, Jinyun; Zhang, Jianhua; Dong, Anjie; Huang, Pingsheng; Wang, Weiwei; Deng, Liandong

doi:10.1016/j.ijbiomac.2020.03.182

Cited by 45 publications

(31 citation statements)

References 63 publications

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“…By improving these properties, the hydrogel-clay nanocomposites have been shown to be optimal for use in applications such as tissue engineering, adhesives, and bioprinting [28,29,34]. Similar observations were made for polymeric NPs, which have been shown to improve the mechanical strength of hydrogels as well as their sensitivity to stimuli for drug delivery applications [25,26]. Researchers have also explored incorporating nanoparticles to enhance the electrical and thermal properties along with the mechanical properties of hydrogels [19,23,33,36,37].…”

Section: Introductionmentioning

confidence: 76%

“…On-demand delivery is a form of drug delivery where a stimulus, either generated in the body or administered externally, causes drug release [51]. Hydrogels can be tailored to respond to stimuli, and therefore are optimally suited for the localized delivery of drugs to more effectively target tumor cells or various pathogens [26,52]. However, without manipulation, many hydrogels may release drugs in an uncontrolled or unpredictable manner [25,26].…”

Section: Drug Deliverymentioning

confidence: 99%

“…Hydrogels can be tailored to respond to stimuli, and therefore are optimally suited for the localized delivery of drugs to more effectively target tumor cells or various pathogens [26,52]. However, without manipulation, many hydrogels may release drugs in an uncontrolled or unpredictable manner [25,26]. The addition of nanoparticles can provide control over the degree of crosslinking and/or porosity, thereby improving their application in drug delivery and injectability.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Researchers have also performed experiments in support of the hypothesis that nanoparticles can contribute to the overall degree of crosslinking within the polymer network and thereby lead to enhancements in their mechanical properties [15,16,[19][20][21][22][23]. Improvements in the mechanical properties of hydrogels have been shown using an assortment of nanoparticle types, including clay [17,18,21,24], carbon-based [19,23], polymeric [25][26][27][28], metal [6], and metal oxide [29] NPs. Studies have also demonstrated enhancements in mechanical properties for IPN hydrogels, which are combinations of two different crosslinked polymers where at least one of the polymers is synthesized or crosslinked in the presence of the other polymer [4,22,30].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is not surprising that several researchers have investigated whether the incorporation of nanoparticles may also improve the chemical properties of hydrogels to expand their utility for other applications, e.g. drug delivery, tissue engineering, adhesives, bioprinting and biowearable devices [6,[17][18][19]21,[23][24][25][26][27]. For instance, it has been shown that not only can the incorporation of clay NPslead to improvements in the mechanical properties of hydrogels in a concentration-dependent manner, but it can also impact a variety of other properties including sensitivity to stimuli and biocompatibility [17,18,21,24].…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Barrett-Catton

Ross

Asuri

2021

Preprint

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Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

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Section: Introductionmentioning

confidence: 76%

Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Barrett-Catton

Ross

Asuri

2021

Preprint

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Dual‐Cured Hydrogels for Bioadhesives and Various Biomedical Applications

Zilberfarb,

Cohen,

Dodiuk

et al. 2023

Progress in Adhesion and Adhesives

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Strategy and Advancement in Hybrid Hydrogel and Their Applications: Recent Progress and Trends

Choudhary,

Sharma,

Singh

et al. 2024

Adv Eng Mater

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Advancements in polymers have made significant contribution in diverse application‐oriented fields. The multidisciplinary application of polymers generates a range of strategies, which is applicable in a wide range of biomedicines. Polymeric compounds such as hydrogels have been explored globally as a potent biomaterial that can furnish essential attributes due to their three‐dimensional (3D) soft and highly hydrophilic polymeric network. These hydrogels have been used extensively in various applications due to their biocompatible, biodegradable, and biosorption nature. However, they have some limitations, owing to their soft nature, low mechanical properties, and unsatisfactory degradation profile. Therefore, there is a need to develop novel, stronger, and more durable hybrid hydrogels with enhanced biocompatible and multifunctional properties. The current review gives a broad spectrum of hybrid hydrogels with its importance and significance. Further, the review highlights the strategies of generation of hybrid hydrogels reinforced with nanomaterials, biomaterials, and nanobiocomposites along with their advantages and disadvantages. The review also features various applications of these hybrid hydrogels in the field of biomedicines, photocatalysis, agriculture, and food industry over the last 5 years. This review will give a comprehensive overview to researchers working in the field of hybrid hydrogels development.

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Dual-crosslinked nanocomposite hydrogels based on quaternized chitosan and clindamycin-loaded hyperbranched nanoparticles for potential antibacterial applications

Cited by 45 publications

References 63 publications

Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Dual‐Cured Hydrogels for Bioadhesives and Various Biomedical Applications

Strategy and Advancement in Hybrid Hydrogel and Their Applications: Recent Progress and Trends

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