Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo

Chang, Ping-Chuan; Dovban, Alex S M; Lim, Lipyeow; Li, Chong; Kuo, Mark Yen‐Ping; Wang, Chi-Hwa

doi:10.1016/j.biomaterials.2013.09.030

Cited by 60 publications

(52 citation statements)

References 30 publications

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“…From the 25 articles selected for full‐text review, 2 were excluded because they assessed statin only in combination with another agent. Finally, 23 preclinical trials were included: 16 studies using an EIP model (Table ) and 7 studies using an ACP model (Table ). Subsequently, these studies will be cited with Roman numbers, as indicated in Tables and .…”

Section: Resultsmentioning

confidence: 99%

“…An interesting aspect is that in contrast to the consistently positive effect after statin use in EIP models, ambiguous results were observed after local application of statins in ACP models, in that only 2 of 7 studies reported a significant, positive effect on alveolar bone parameters . In particular, in 2 out of 3 studies using large animal platforms, either similarly poor outcomes for both test and control groups in dehiscence defects or a significantly inferior effect of local statin application compared with controls in 3‐wall intrabony defects was observed.…”

Section: Discussionmentioning

confidence: 98%

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Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta‐analysis of preclinical in vivo trials

Bertl

Steiner

Pandis

et al. 2017

J of Periodontal Research

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The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally induced periodontitis (EIP) and/or acute/chronified periodontal defect (ACP) models? A literature search (of Medline/PubMed, Embase/Ovid, CENTRAL/Ovid) using the following main eligibility criteria was performed: (i) English or German language; (ii) controlled preclinical in vivo trials; (iii) local and/or systemic statin use in EIP and/or ACP models; and (iv) quantitative evaluation of periodontal tissues (i.e., alveolar bone level/amount, attachment level, cementum formation, periodontal ligament formation). Sixteen studies in EIP models and 7 studies in ACP models evaluated simvastatin, atorvastatin or rosuvastatin. Thirteen of the EIP (81%) and 2 of the ACP (29%) studies presented significantly better results in terms of alveolar bone level/amount in favor of statins. Meta-analysis based on 14 EIP trials confirmed a significant benefit of local and systemic statin use (P < .001) in terms of alveolar bone level/amount; meta-regression revealed that statin type exhibited a significant effect (P = .014) in favor of atorvastatin. Three studies reported a significantly higher periodontal attachment level in favor of statin use (P < .001). Complete periodontal regeneration was never observed; furthermore, statins did not exert any apparent effect on cementum formation. Neither local nor systemic use of statins resulted in severe adverse effects. Statin use in periodontal indications has a positive effect on periodontal tissue parameters, supporting the positive results already observed in clinical trials. Nevertheless, not all statins available have been tested so far, and further research is needed to identify the maximum effective concentration/dose and optimal carrier.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta‐analysis of preclinical in vivo trials

Bertl

Steiner

Pandis

et al. 2017

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…All microspheres showed adequate biocompatibility in vivo because of elevated proliferation, decreased apoptosis, and diminished inflammation. Their subsequent study further examined effects of the combination and sequential release of PDGF and simvastatin from core-shell microparticles encapsulating simvastatin in the core and PDGF in the shell on the periodontal regeneration (Chang et al, 2013). The microparticles had a diameter of around 15 μm with evident core-sheath structure, which released PDGF rapidly followed by gradual-release of simvastatin, showing significantly larger volume fraction of regenerated bone tissue and a clear reduction in trabecular separation at day 14 and 28 when compared to the control (Fig.…”

Section: Applicationsmentioning

confidence: 99%

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Xie

Jiang

Davoodi

et al. 2015

Chemical Engineering Science

Self Cite

268

159

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Electrohydrodynamic atomization (EHDA), also called electrospray technique, has been studied for more than one century. However, since 1990s it has begun to be used to produce and process micro-/nanostructured materials. Owing to the simplicity and flexibility in EHDA experimental setup, it has been successfully employed to generate particulate materials with controllable compositions, structures, sizes, morphologies, and shapes. EHDA has also been used to deposit micro- and nanoparticulate materials on surfaces in a well-controlled manner. All these attributes make EHDA a fascinating tool for preparing and assembling a wide range of micro- and nanostructured materials which have been exploited for use in pharmaceutics, food, and healthcare to name a few. Our goal is to review this field, which allows scientists and engineers to learn about the EHDA technique and how it might be used to create, process, and assemble micro-/nanoparticulate materials with unique and intriguing properties. We begin with a brief introduction to the mechanism and setup of EHDA technique. We then discuss issues critical to successful application of EHDA technique, including control of composition, size, shape, morphology, structure of particulate materials and their assembly. We also illustrate a few of the many potential applications of particulate materials, especially in the area of drug delivery and regenerative medicine. Next, we review the simulation and modeling of Taylor cone-jet formation for a single and co-axial nozzle. The mathematical modeling of particle transport and deposition is presented to provide a deeper understanding of the effective parameters in the preparation, collection and pattering processes. We conclude this article with a discussion on perspectives and future possibilities in this field.

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“…It is possible that WISP1 acts on mesenchymal stem cells migrated by BMP-2 to enhance osteogenesis. Collectively, these studies on dual release of bioactive molecules and BMP-2 suggest that the cells recruited by BMP-2 induce the osteogenic differentiation, whereas bioactive molecules alone have no function to promote differentiation.Chang et al[173] investigated whether dual release of PDGF and simvastatin influences . PDGF and simvastatin were encapsulated in double-walled poly-(D,L-lactide) andpoly-(D,L-lactide-co-glycolide) (PDLLA-PLGA) microspheres with core-shell structure.…”

mentioning

confidence: 99%

Dual-controlled release system of drugs for bone regeneration

Kim

Tabata

2015

Advanced Drug Delivery Reviews

113

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Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo

Cited by 60 publications

References 30 publications

Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta‐analysis of preclinical in vivo trials

Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta‐analysis of preclinical in vivo trials

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Dual-controlled release system of drugs for bone regeneration

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