Dual diagnosis of pemphigus vulgaris and connective tissue disease

Spectrum of autoantibodies other than anti‐desmoglein in pemphigus patients

“…In fact, before our study, only Mendes et al. 22 and some case reports described their presence in pemphigus patients 30 …”

“…Moreover, the presence of anti-ds-DNA Abs in pemphigus patients was frequently reported in cases with dual concomitant diagnosis of pemphigus and lupus. [29][30][31][32] As ANA, the assessment of AMA revealed that they were rarely depicted in our screening; they were detected only in one (0.83%) PF patient. The presence of these Abs was also reported by Mendes et al 22 in two (7.1%) of 28 endemic PF patients.…”

“…Thus, our finding suggests a clinical follow‐up to assess lupus settlement. Moreover, the presence of anti‐ds‐DNA Abs in pemphigus patients was frequently reported in cases with dual concomitant diagnosis of pemphigus and lupus 29–32 …”

“…In fact, before our study, only Mendes et al 22 and some case reports described their presence in pemphigus patients. 30 Coeliac disease (CD) related Abs (ATG, ARA, AGD, AEA) were searched in this study. Although AEA were scarcely observed in this study, ARA and AGD (IgG) were frequently detected among PV patients with a significant difference.…”

Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously

“…MMP has been reported in patients with SLE, connective tissue disease (CTD) and RA [90][91][92][93][94][95]. Also, PV has been reported with SLE, CTD, MS, MG, alopecia universalis, insulin-dependent diabetes mellitus, autoimmune thyroid disease, Sjögren's syndrome and systemic sclerosis [96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113].…”