Dual-Drug-Loaded Core–Shell Electrospun Nanofiber Dressing for Deep Burns

Abstract

The epidermis of a deep burn wound is entirely absent and the dermal tissue sustains significant damage, accompanied by a substantial amount of tissue exudate. Due to the excessively humid environment, the formation of a scab on the wound becomes challenging, leaving it highly vulnerable to external bacterial invasion. In this work, a core−shell dual-drug-loaded nanofiber dressing was prepared by electrospinning technology for the synergistic treatment of a deep burn. The shell layer consists of polycaprolactone and chitosan encapsulating asiaticoside, with the core layer comprising the clathrate of 2hydroxypropyl-β-cyclodextrin and curcumin. Upon application to the wound, the dual-drug-loaded nanofiber dressing exhibited rapid release of asiaticoside, stimulating collagen deposition and promoting tissue repair. The core−shell structure and clathrate configuration ensured sustained release of curcumin, providing antibacterial and anti-inflammatory functions for the wound. The mechanical strength, broad-spectrum antibacterial ability, cell proliferation, and adhesion ability of the nanofiber dressing showed its potential as a medical dressing. This dressing also exhibited excellent wound healing promoting effects in the SD rat burn model. This paper provides a strategy for burn wound healing.

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

“…42–45 Biphasic release, as an advanced type of rate-controlled drug release, has demonstrated its value in treating several kinds of diseases with some commercial products. 46–49 Among the different sorts of biphasic release profiles, the one with an initial fast release and a second sustained release represents the most popular case. Electrospun nanofibers (composed by blending a soluble polymer with an insoluble polymer with Janus and core–shell structures and even tri-layer structures) have demonstrated their capability in these special applications.…”

“…However, these hybrid structures (with beads around one side of the fibers and core–shell beads randomly distributed all over the fibrous mats) were verified to be useful for providing the desired biphasic release. 46–51 Meanwhile, the different organizations of fibrous mats can open new ways of developing DDSs with biphasic release, such as the integration of an electrospun film for fast release, casting a solid film for sustained release, and employing a sandwich structure with outer layers for fast release and an inner layer for extended release. 52 Although these strategies have been reported, there have been no reports about biphasic release from Janus particles.…”

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

“…The nozzle of a spinneret at the macroscale can be explored as a template to duplicate a wide variety of complex multicompartment nanoproducts through electrospinning ( Song et al, 2023 ; Tabakoglu et al, 2023 ). These fundamental multichamber nanoproducts include but are not limited to, the core-shell ( Shi et al, 2024a ; Han et al, 2024 ), Janus ( Zhang et al, 2024b ; Yan et al, 2024 ; Zhou et al, 2024b ), trilayer core-shell ( Wang et al, 2020 ; Wang et al, 2023b ), trisection Janus ( Wang et al, 2017 ; Jiang et al, 2024 ; Xu et al, 2024b ), combinations of Janus and core-shell ( Li et al, 2024 ), and abundant derivatives ( Li et al, 2022 ; Guler et al, 2023 ) of these multichamber structures. For example, the derivatives of trilayer core-shell nanofibers can be used as drug gradient distribution nanofibers for sustained release ( Wang et al, 2023c ) and as drug discrete distribution nanofibers for accurate biphasic release ( Liu et al, 2024 ).…”