Dual effect of lectins on macrophages: Potentiation of bacterial uptake and suppression of bactericidal activity

Gallily, Ruth; Stain, I; Zaady, O.

doi:10.1016/0165-2478(86)90048-9

Cited by 2 publications

(1 citation statement)

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“…Lectinophagocytosis results in efficient bacterial uptake by eukaryotic cells through specific receptor recognition of lectins provided by the bacteria or the host cell (25,26). Plant lectins can also mediate macrophage lectinophagocytosis (27,28), and in some cases this is concomitant with the suppression of bacterial killing (29). It is well known that lectins target bacteria for destruction by the innate immune system of the host, but there are reports of lectins with functions unrelated to defense (30,31).…”

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Lectins modulate the microbiota of social amoebae

Dinh

Farinholt

Hirose

et al. 2018

Science

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The social amoeba maintains a microbiome during multicellular development; bacteria are carried in migrating slugs and as endosymbionts within amoebae and spores. Bacterial carriage and endosymbiosis are induced by the secreted lectin discoidin I that binds bacteria, protects them from extracellular killing, and alters their retention within amoebae. This altered handling of bacteria also occurs with bacteria coated by plant lectins and leads to DNA transfer from bacteria to amoebae. Thus, lectins alter the cellular response of to bacteria to establish the amoebae's microbiome. Mammalian cells can also maintain intracellular bacteria when presented with bacteria coated with lectins, so heterologous lectins may induce endosymbiosis in animals. Our results suggest that endogenous or environmental lectins may influence microbiome homeostasis across eukaryotic phylogeny.

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