Dual Effect of low‐level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: Action on anti‐ and pro‐inflammatory cytokines

Lima, Flávia Mafra de; Villaverde, Antonio; Albertini, Regiane; Corrêa, João Carlos Ferrari; Carvalho, R.L.P.; Munin, Egberto; Araújo, Ticiana Vasques de; Silva, J.A.; Aimbire, Flávio

doi:10.1002/lsm.21053

Cited by 101 publications

(61 citation statements)

References 37 publications

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“…10,29 IIR challenge results in translocation of bacteria and toxins, which amplifies systemic inflammation and oxidative stress, and leads to ALI and ARDS. 2,3,4,32 Oxidative stress is a disturbance in the balance between the production of free radicals and antioxidant defense systems. Free radicals are generated in the form of reactive oxygen species (ROS), including superoxide anions, hydrogen peroxide, hydroxyl radicals, and singlet oxygen.…”

Section: Role Of Nrf2 Q-t Meng Et Almentioning

confidence: 99%

“…2,3 The lungs are often the most frequently affected organs by IIR, and in some instances it leads to the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). 4 Despite numerous attempts to improve the outcome in patients with ARDS, a mortality rate around 50% is still encountered. 5 Ischemic post-conditioning (IPo) has been demonstrated to be beneficial following ischemia/reperfusion (IR) injury in the heart, brain, liver, kidney, and spinal cord, 6 and its mechanical interventions against reperfusion injury relate to multiple and interacting components in endogenous protective mechanisms.…”

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confidence: 99%

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Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

Meng

Cao²,

et al. 2016

Laboratory Investigation

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Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

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Section: Role Of Nrf2 Q-t Meng Et Almentioning

confidence: 99%

mentioning

confidence: 99%

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

Meng

Cao²,

et al. 2016

Laboratory Investigation

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“…Furthermore, LLLT modulates the expression of some inflammatory mediators such as Cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNFα), interleukin 1β, (IL1β), and interleukin 10 (IL10) [7,15,16]. Moreover, it has been demonstrated that LLLT can stimulate VEGF expression and angiogenesis [6,17].…”

Section: Introductionmentioning

confidence: 99%

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

et al. 2015

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This study evaluated the morphological changes produced by LLLT on the initial stages of bone healing and also studied the pathways that stimulate the expression of genes related to bone cell proliferation and differentiation. One hundred Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 94 s, 2.8 J) was performed for 1, 2, 3, 5, and 7 sessions. Histopathology revealed that treated animals produced increased amount of newly formed bone at the site of the injury. Moreover, microarray analysis evidenced that LLLT produced a significant increase in the expression TGF-β, BMP, FGF, and RUNX-2 that could stimulate osteoblast proliferation and differentiation, which may be related to improving the deposition of newly formed bone at the site of the injury. Thus, it is possible to conclude that LLLT improves bone healing by producing a significant increase in the expression of osteogenic genes.

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“…More recently, LLLT has shown interesting results regarding the repair of muscle damage, increase wound healing, reducing pain, and inflammation both in animal models [22,[24][25][26][27] as well as in humans [28,29]. Several studies have demonstrated the effectiveness of LLLT in treating the inflammatory process, and these studies indicated the modulating property of laser light toward anti-inflammatory and proinflammatory mediators [30][31][32]. However, other studies have shown a failure of LLLT in conditions involving joint damage [33,34].…”

Section: Discussionmentioning

confidence: 99%

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

Eid

Aly

2015

Lasers Med Sci

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Children with hemophilia usually have recurrent joint bleeding that leads to joint damage, loss of range of motion, and restriction of mobility, therefore affecting the quality of life in these children. The purpose of this study was to compare the effects of lowlevel laser therapy (LLLT) to that of pulsed electromagnetic field (PEMF) in treatment of hemarthrosis in children with hemophilia. Thirty boys with hemophilia A with ages ranging from 9 to 13 years were selected and assigned randomly, using sealed envelopes, into two equal intervention groups. The study group I received the traditional physical therapy program in addition to LLLT, whereas the study group II received the same physical therapy program given to the study group I in addition to PEMF. Both groups received the treatment sessions three times per week for three successive months. Pain, laboratory investigations, swelling, and range of motion (ROM) of the affected knee joint, in addition to physical fitness were evaluated before, at the end of the sixth week and at 12 weeks of the treatment program. Laser group showed significant improvement in all measured variables after the sixth week of treatment when compared with PEMF. By 12 weeks of treatment, there was a significant improvement in pain, ROM, ESR and leucocytes levels in laser group compared with PEMF, while there was no significant difference in knee circumferences and the 6-min walk test (6MWT) between both groups. Both groups showed significant improvement at 12 weeks of treatment compared with that at 6 weeks. Both LLLT and PEMF are effective modalities in reducing pain, swelling, increasing ROM and improving physical fitness. Twelve weeks of treatment of both modalities demonstrated significant improvement than 6 weeks of treatment. Laser therapy induced significant improvement than electromagnetic therapy in treatment of hemarthrosis-related problems in children with hemophilia.

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Dual Effect of low‐level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: Action on anti‐ and pro‐inflammatory cytokines

Abstract: The results indicate that the LLLT attenuates the i-I/R-induced acute lung inflammation which favor the IL-10 production and reduce TNF generation.

Cited by 101 publications

References 37 publications

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

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