Dual effect of red wine on liver redox status: a concise and mechanistic review

Abstract

Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

“…Cigarette smoking reduces the levels of SOD through the elevation of hydrogen peroxide which inactivates SOD. Since resveratrol elevates the levels of SOD, this would reduce oxidative stress and attendant destruction of tissues related to this condition . Resveratrol has also been shown to upregulate production of the transcription factor, Nrf2 (nuclear factor erythroid 2‐related factor 2).…”

“…SMK+PLAC oxidative stress and attendant destruction of tissues related to this condition. [79][80][81][82][83] Resveratrol has also been shown to upregulate production of the transcription factor, Nrf2 (nuclear factor erythroid 2-related factor 2). Nrf2 is an important modulator of the antioxidant response which regulates the expression of antioxidant genes including SOD.…”

Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells

“…Moreover, oxidative stress is associated with ageing [10,11] and life-style factors, such as excessive alcohol consumption [12] and cigarette smoking [13,14]. However, there is growing evidence that reactive oxygen species (ROS) may play a possible physiological role as redox signalling messengers for some regulatory functions [15].…”

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“…Previous studies have reported the hepato and renal protective effects of S. cumini fruit, red wine and polyphenols of Jamun fruit and red wine, respectively. [37][38][39] It has been found that in mice S. cumini pulp extract decreases bile duct ligation induced inflammation and oxidative stress in addition to providing protection against hepatocellular injury. 40 Similarly, significant reductions in liver marker enzymes were observed after 14 weeks of fruit extract administration to hyperlipidemic animals and the authors ascribed the presence of flavonoids for the observed liver protective activity.…”