Dual effect of statin medication on the periodontium

Saxlin, Tuomas; Suominen-Taipale, Liisa; Knuuttila, Matti; Alha, Pirkko; Ylöstalo, Pekka

doi:10.1111/j.1600-051x.2009.01484.x

Cited by 51 publications

(53 citation statements)

References 23 publications

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“…Regarding the systemic consumption of statins by patients at risk for CVD, recent retrospective studies 35,36 have supported a positive role of statins for the periodontium. The findings of Saxlin et al 37 also lend credence to this assumption.…”

mentioning

confidence: 80%

“…Another retrospective study by Lindy et al 36 concluded that statin medication use was associated significantly with fewer signs of periodontal inflammatory injury. Saxlin et al 37 concluded that the effect of statins on the periodontium may depend on the inflammatory status of periodontium.…”

Section: Discussionmentioning

confidence: 99%

“…This is important because both hyperlipidemia and periodontitis are risk factors for CVD, and patients with CVD risk are frequently prescribed statins 2‐4,19,29 . After conducting a careful search of published literature, to the best of our knowledge there are only two previous studies 22,23 in which three such groups have been compared at once, although separate comparisons between patients on the basis of either serum lipid levels 10,12,18,21‐23 or statin use 36,37 have been carried out frequently in the past.…”

Section: Discussionmentioning

confidence: 99%

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Periodontal Status and Hyperlipidemia: Statin Users Versus Non‐Users

Sangwan

Tewari

Singh

et al. 2013

Journal of Periodontology

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Background: The association between serum lipids and periodontal disease has been studied predominantly in patients with chronic periodontitis with limited data available regarding periodontal status of patients with hyperlipidemia. Meanwhile, the impact of statins on the periodontal health of the population also remains largely underexplored. This study aims to assess the periodontal status among patients with hyperlipidemia and users of statins.Methods: In this cross‐sectional study, 94 patients with hyperlipidemia (50 receiving statins and 44 receiving non‐pharmacologic therapy) and 46 control individuals who were normolipidemic underwent periodontal examination (plaque index, gingival index [GI], probing depth [PD], and clinical attachment level [CAL]). Biochemical parameters measured included serum triglyceride (TG), total cholesterol (TC), low‐density lipoprotein (LDL) cholesterol, and high‐density lipoprotein cholesterol levels.Results: PD and GI were significantly higher in patients with hyperlipidemia who were non‐statin users compared with the normolipidemic individuals (P <0.001 [PD] and P <0.05 [GI]) and the statin group (P = 0.001 [PD] and P <0.05 [GI]). Periodontal parameters between statin users and the normolipidemic group did not differ significantly. After adjusting for confounders, positive and significant correlations were observed between PD and TG, and TC and LDL, whereas CAL shared correlation with TC and LDL. GI was correlated with TG and TC. Regression analyses revealed that whereas TC was associated significantly with PD (P <0.001), LDL showed significant association with CAL (P = 0.013). TG showed significant association with GI (P = 0.020).Conclusions: Our findings suggest that relative to the general population, patients with hyperlipidemia are more prone to periodontal disease. Also, within the limits of this study, statins have a positive impact on periodontal health.

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confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Periodontal Status and Hyperlipidemia: Statin Users Versus Non‐Users

Sangwan

Tewari

Singh

et al. 2013

Journal of Periodontology

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“…Conversely, Saxlin et al. (41) reported that among subjects with no gingival bleeding, statin medication was associated with an increased likelihood of having teeth with deepened periodontal pockets. Two recently completed prospective studies support the role of statins as an adjunctive therapeutic in the treatment of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Statins regulate interleukin-1β-induced RANKL and osteoprotegerin production by human gingival fibroblasts

Stein

Dean

Rawal

et al. 2011

Journal of Periodontal Research

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“…It was shown that patients on statin medication exhibited reduced periodontal injury as compared to subjects without the drugs [9]. Statin medication may have some beneficial effects when subjects have dental plaque or signs of periodontitis as gingival bleeding [10]. Thus, the question arises whether statins may have an influence on periodontal parameters by affecting either the inflammation or the association between the disease and the cholesterol concentration or both.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

et al. 2011

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Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determined periodontal measures, cholesterol fractions, and inflammation markers. Statin use and periodontal risk factors were assessed. Gingival plaque and periodontal attachment loss were associated with systemic LDL cholesterol (P < 0.001) and C-reactive protein CRP (P = 0.019) revealing interaction with statin use. When adjusted for age, sex, smoking, diabetes, education, and dental service, statins were identified as effect modifiers abolishing the relationship between attachment loss and LDL and between gingival plaque and LDL (interactions P < 0.001). No statin-related interaction was detected with increase in CRP. The interaction supports the view of inter-relationships between periodontal and systemic inflammatory mediators.

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Dual effect of statin medication on the periodontium

Abstract: Statin medication appears to have an effect on the periodontium that is dependent on the inflammatory condition of the periodontium. More evidence is needed to achieve a comprehensive understanding of the effects of statins.

Cited by 51 publications

References 23 publications

Periodontal Status and Hyperlipidemia: Statin Users Versus Non‐Users

Periodontal Status and Hyperlipidemia: Statin Users Versus Non‐Users

Statins regulate interleukin-1β-induced RANKL and osteoprotegerin production by human gingival fibroblasts

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

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