Dual effects of circRNA in thyroid and breast cancer

Guo, Rina; Zhang, Rui

doi:10.1007/s12094-023-03173-x

Cited by 5 publications

(2 citation statements)

References 66 publications

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“…Functioning as competitive endogenous RNAs (ceRNAs) is the main mechanism by which circRNAs regulate gene expression 16 . The term ceRNA refers to competitive binding of miRNAs to endogenous RNA molecules with the same MREs to regulate each other's expression levels 17 .…”

Section: Discussionmentioning

confidence: 99%

Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer

Shao,

Yu,

et al. 2024

J. Cancer

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Section: Discussionmentioning

confidence: 99%

Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer

Shao,

Yu,

et al. 2024

J. Cancer

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“…Circular RNA (circRNA) has a great advantage in becoming a biomarker for human diseases, including cancer. [ 5,6 ] CircRNA plays a vital part in cancer progression and shows great potential in cancer diagnosis, prognosis and treatment. [ 7 ] CircRNA can be used as an oncogene to promote cancer progression, [ 8 ] or as a tumor suppressor to inhibit the malignant biological behaviors of cancer.…”

Section: Introductionmentioning

confidence: 99%

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Liu,

Wu,

Wang

et al. 2024

J Biochem & Molecular Tox

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Circular RNA is an important regulator for non‐small cell lung cancer (NSCLC). Circ_0000735 has been found to be significantly overexpressed in NSCLC tissues. Therefore, its role and mechanism in NSCLC progression need to be further explored. The expression levels of circ_0000735, miR‐345‐5p and A disintegrin and metalloprotease 19 (ADAM19) were determined using quantitative real‐time PCR. EdU staining, wound healing and transwell assays were utilized to detect cell proliferation and metastasis. The protein levels of metastasis markers, exosome markers and ADAM19 were determined using western blot. Animal experiments were performed to confirm the role of circ_0000735 in NSCLC tumorigenesis. The exosomes from cells and serum were identified using transmission electron microscopy and nanoparticle tracking analysis. We found that circ_0000735 was upregulated in NSCLC, and its knockdown repressed NSCLC cell proliferation and metastasis. In terms of mechanism, circ_0000735 targeted miR‐345‐5p to regulate ADAM19. MiR‐345‐5p inhibitor reversed the suppressive effect of circ_0000735 knockdown on NSCLC progression, and ADAM19 overexpression abolished the inhibition effect of miR‐345‐5p on NSCLC progression. Also, animal experiments showed that silencing of circ_0000735 reduced NSCLC tumorigenesis. In addition, exosomes mediated the intercellular transmission of circ_0000735, and serum exosomal circ_0000735 might be an important indicator for the diagnosis of NSCLC. In conclusion, circ_0000735 facilitated NSCLC progression via miR‐345‐5p/ADAM19 pathway, and serum exosomal circ_0000735 might be a potential biomarker for NSCLC diagnosis.

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Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR‐506‐3p/AURKA axis

Hu,

Wu,

Tan

et al. 2024

J Biochem & Molecular Tox

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Colon cancer contributes to high mortality rates internationally that has seriously endangered human health. Aurora kinase A (AURKA) served as a key molecule in colon cancer. However, its role of AURKA on regulating ferroptosis in colon cancer and their possible interactions with miRNAs and circRNAs remain still elusive. Comprehensive bioinformatics analysis after RNA‐sequencing was conducted to determine the differentially expressed genes (DEGs), ferroptosis‐related DEGs and hub genes. The direct relationship between miR‐506‐3p and hsa_circRNA_007630 or AURKA was predicted, then verified by dual luciferase reporter and quantitative real‐time polymerase chain reaction. The rescue experiments were conducted by cotransfection with si‐hsa_circRNA_007630, miR‐506‐3p inhibitor or pcDNA‐AURKA in HT29 cells. Erastin was used to induce ferroptosis in HT29 cells and validated by detecting levels of intracellular Fe2+, lipid reactive oxygen species, glutathione, malondialdehyde and ferroptosis markers expression. We screened a total of 331 DEGs, 26 ferroptosis‐related genes, among which 3 hub genes were identified through PPI network analysis. Therein, AURKA expression was elevated in colon cancer cells. Moreover, AURKA was targeted by miR‐506‐3p, and hsa_circRNA_007630 operated as miR‐506‐3p sponge. The effect of hsa_circRNA_007630 depletion on the inhibiting malignant phenotypes of HT29 cells was rescued by inhibition of miR‐506‐3p or AURKA overexpression. Additionally, AURKA reduced erastin‐induced ferroptosis in HT29 cells. Depletion of circRNA_007630 exerts as a suppressive role in colon cancer through a novel miR‐506‐3p/AURKA pathway related to ferroptosis, and might become a novel marker for colon cancer.

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Dual effects of circRNA in thyroid and breast cancer

Cited by 5 publications

References 66 publications

Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer

Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR‐506‐3p/AURKA axis

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