Dual Effects of Hyperprolactinemia on Carrageenan-Induced Inflammatory Paw Edema in Rats

Ochoa-Amaya, Julieta E.; Malucelli, Benjamin Eurico; Cruz‐Casallas, Pablo E.; Nasello, Antonia G.; Felício, Luciano Freitas; Carvalho-Freitas, M.I.R.

doi:10.1159/000323774

Cited by 11 publications

(6 citation statements)

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“…The data presented here mostly cover short-term actions (Ͻ5 days) of PRL and PRL-R and demonstrate that the disruption of PRL and PRL-R significantly decreases inflammatory hyperalgesia at 1-24 h post-CFA. Interestingly, shortterm hyperprolactinemia increased inflammatory edema in male animals, whereas long-term 30-day hyperprolactinemia had anti-inflammatory effects (1,55). Fifth, it has been shown that PRL produces antihyperalgesic effects in lactating females (60,63).…”

Section: Discussionmentioning

confidence: 98%

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

Patil

Ruparel

Henry

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

113

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Patil MJ, Ruparel SB, Henry MA, Akopian AN. Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain. Am J Physiol Endocrinol Metab 305: E1154-E1164, 2013. First published September 10, 2013; doi:10.1152/ajpendo.00187.2013 is a hormone produced in the anterior pituitary but also synthesized extrapituitary where it can influence diverse cellular processes, including inflammatory responses. Females experience greater pain in certain inflammatory conditions, but the contribution of the PRL system to sexdependent inflammatory pain is unknown. We found that PRL regulates transient receptor potential (TRP) channels in a sex-dependent manner in sensory neurons. At Ͼ20 ng/ml, PRL sensitizes TRPV1 in female, but not male, neurons. This effect is mediated by PRL receptor (PRL-R). Likewise, TRPA1 and TRPM8 were sensitized by 100 ng/ml PRL only in female neurons. We showed that complete Freund adjuvant (CFA) upregulated PRL levels in the inflamed paw of both male and female rats, but levels were higher in females. In contrast, CFA did not change mRNA levels of long and short PRL-R in the dorsal root ganglion or spinal cord. Analysis of PRL and PRL-R knockout (KO) mice demonstrated that basal responses to cold stimuli were only altered in females, and with no significant effects on heat and mechanical responses in both sexes. CFA-induced heat and cold hyperalgesia were not changed in PRL and PRL-R KO compared with wild-type (WT) males, whereas significant reduction of heat and cold post-CFA hyperalgesia was detected in PRL and PRL-R KO females. Attenuation of CFA-induced mechanical allodynia was observed in both PRL and PRL-R KO females and males. Thermal hyperalgesia in PRL KO females was restored by administration of PRL into hindpaws. Overall, we demonstrate a sex-dependent regulation of peripheral inflammatory hyperalgesia by the PRL system. prolactin receptor; transient receptor potential V1; transient receptor potential A1; transient receptor potential M8; female; inflammation; pain MANY HUMAN CHRONIC INFLAMMATORY conditions are associated with hyperprolactinemia, and this increase in prolactin (PRL) levels can lead to serious health issues related to cancer, infertility, inflammatory diseases, and body weight (11,42,48,73). Human inflammatory conditions with increased PRL serum levels include the severe form of progressive systemic sclerosis (34, 69), the active phase of systemic lupus erythematosus (37, 74), rheumatoid arthritis (44), polymyalgia rheumatica (68), and autoimmune thyroid diseases (26). Unlike chronic inflammation, acute inflammation in animals triggers an accumulation of endogenous PRL at the site of inflammation, but not in blood serum (64). Altogether, these findings suggest that acute inflammation upregulates PRL via extrapituitary mechanisms, whereas chronic inflammation induces PRL via both pituitary and extrapituitary pathways (64, 75).Elevated PRL can have modulatory effects on metabolic/ endocrine and the ...

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Section: Discussionmentioning

confidence: 98%

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

Patil

Ruparel

Henry

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

113

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“…Domperidone was administered at a dose of 1.7 mg × kg– – (i.p.) 3 times per day (6: 30 a.m., 2: 00 p.m., and 9: 00 p.m., therefore a total of 5.1 mg × kg –1 per day) for 5 consecutive days from the 10th to 14th day after OVA immunization [13, 37, 38]. This treatment protocol has effectively produced stable hyperprolactinemia for more than 30 days [13, 39].…”

Section: Methodsmentioning

confidence: 99%

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Ochoa-Amaya

Queiroz‐Hazarbassanov

Namazu

et al. 2018

Neuroimmunomodulation

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Purpose: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung’s allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. Methods: To induce hyperprolactinemia, domperidone was injected intraperitoneally in rats at a dose of 5.1 mg × kg^–1 per day for 5 days. P2X7 expression was evaluated by lung immunohistochemistry while prolactin receptor expression in bronchoalveolar lavage leukocytes was analyzed through flow cytometry. Results: Previous reports demonstrated that rats subjected to short-term hyperprolactinemia exhibited a decrease in leukocyte counts in bronchoalveolar lavage, especially granulocytes. Here, it is revealed that hyperprolactinemia promotes an increased expression of prolactin receptors in granulocytes. Also, increased expression of purinergic P2X7R observed in allergic animals was significantly reduced by hyperprolactinemia. Conclusions: Both purinergic and prolactin receptor expression changes occur during the anti-asthmatic effect of hyperprolactinemia.

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“…É amplamente conhecido que a administração de domperidona por sua propriedade de bloquear os receptores D2 de dopamina, particularmente aqueles do sistema dopaminérgico tuberoinfundibular, induz hiperprolactinemia (BAILEY; HERBERT, 1982;BRIDGES, 1992;NASELLO et al, 1997;CRUZ-CASALLAS et al, 1999;OCHOA-AMAYA et al, 2011. Os resultados do primeiro experimento da tese confirmam esse efeito da domperidona e são consistentes com achados anteriores do nosso laboratório (BAILEY;HERBERT, 1982;CHAMPION, 1988;BRIDGES, 1992;NASELLO et al, 1997;CRUZ-CASALLAS et al, 1999;OCHOA-AMAYA et al, 2010, 2011.…”

Section: Discussionunclassified

“…Além disso, níveis elevados de citocinas pró-inflamatórias Th2 como IL-5 (ZHOU et al, 2015), IL6 (WONG et al, 2001 -FREITAS et al, 2007-FREITAS et al, , 2008-FREITAS et al, , 2011 A prolactina promove respostas imunes pró-inflamatórias via NFκB e fator regulatório do interferon 1 (IRF-1), que é um fator de transcrição multifuncional e um importante regulador da diferenciação e maduração dos linfócitos T e B (MÉNDEZ-HERNÁNDEZ; CARIÑO; DÍAZ, 2005). Esses fatores citados são conhecidos por induzir aumento do TNFα considerado mediador essencial de inflamação (OCHOA-AMAYA et al, 2011). O TNFα é uma citocina pro-inflamatória (BERRY et al, 2007) com uma extensa organização de atividades imuno-modulatórias (RUSSO; POLOSA, 2005;OYOSHI et al, 2008), sua função precisa na patogênese da asma ainda não está muito clara (OYOSHI et al, 2008 (NAGATA et al, 1999).…”

Section: Discussionunclassified

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<b>Efeitos da hiperprolactinemia sobre a inflamação alérgica pulmonar em ratos Wistar</b>

Amaya¹

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Dual Effects of Hyperprolactinemia on Carrageenan-Induced Inflammatory Paw Edema in Rats

Cited by 11 publications

References 106 publications

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

<b>Efeitos da hiperprolactinemia sobre a inflamação alérgica pulmonar em ratos Wistar</b>

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