Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice

Bogdanova, L. A.; Morozkova, T. S.; Amitina, S. A.; Mazhukin, Dmitrii G.; Николин, В. П.; Попова, Н. А.; Каледин, В. И.

doi:10.1007/s10517-014-2602-1

Cited by 1 publication

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“…The IDO inhibitors ethyl pyruvate and amidoxime slightly suppress the growth of the Ehrlich tumor in mice and potentiates the therapeutic effect of cyclophosphamide [ 97 ]. In turn, EOS200271, the novel, selective, non-competitive, orally bioavailable IDO1 inhibitor, demonstrated a potent antitumor effect in the breast cancer animal model.…”

Section: Modulation Of Kynurenine Pathway Activity In the Management Of Neoplastic Diseasesmentioning

confidence: 99%

Kynurenines as a Novel Target for the Treatment of Malignancies

2021

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Malignancies are unquestionably a significant public health problem. Their effective treatment is still a big challenge for modern medicine. Tumors have developed a wide range of mechanisms to evade an immune and therapeutic response. As a result, there is an unmet clinical need for research on solutions aimed at overcoming this problem. An accumulation of tryptophan metabolites belonging to the kynurenine pathway can enhance neoplastic progression because it causes the suppression of immune system response against cancer cells. They are also involved in the development of the mechanisms responsible for the resistance to antitumor therapy. Kynurenine belongs to the most potent immunosuppressive metabolites of this pathway and has a significant impact on the development of malignancies. This fact prompted researchers to assess whether targeting the enzymes responsible for its synthesis could be an effective therapeutic strategy for various cancers. To date, numerous studies, both preclinical and clinical, have been conducted on this topic, especially regarding the inhibition of indoleamine 2,3-dioxygenase activity and their results can be considered noteworthy. This review gathers and systematizes the knowledge about the role of the kynurenine pathway in neoplastic progression and the findings regarding the usefulness of modulating its activity in anticancer therapy.

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Section: Modulation Of Kynurenine Pathway Activity In the Management Of Neoplastic Diseasesmentioning

confidence: 99%