Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation

Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects

“…Controversial results have been reported regarding the effects of systemically administered L-arginine in the FST. Although several groups showed that L-arginine systemic administration did not induce depressive-like behaviors in rodents (Heiberg et al 2002;Rosa et al 2003;Volke et al 2003), this drug can produce opposite effects in the FST depending on the dose tested (Inan et al 2004). Another possible explanation for the absence of SIN-1 effects in our studies is a difference between the effects of endogenousand exogenous-produced NO.…”

“…Another possible explanation for the absence of SIN-1 effects in our studies is a difference between the effects of endogenousand exogenous-produced NO. Corroborating this proposal, some studies have found that NO donors and NOS inhibitors can have similar effects, depending on the tested doses (Segieth et al 2000;Inan et al 2004).…”

“…NO effects could vary depending on factors such as the composition of the extracellular fluid and the functional state of the target neurons (Contestabile 2000). Corroborating this suggestion, dual effects have been reported in several neurochemical (Kiss 2000;Prast and Philippu 2001), behavioral (Inan et al 2004), and molecular (Cárdenas et al 2005) studies investigating NOmediated effects.…”

The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test

“…In line with this, several studies have shown that NOS inhibitors exert antidepressant-like effects in animal models (da Silva et al 2000;Harkin et al 1999Harkin et al , 2003Heiberg et al 2002;Joca and Guimarães 2006;Volke et al 2003). However, an antidepressant-like action was also observed with the administration of the substrate for NOS, l-arginine (da Silva et al 2000;Inan et al 2004;Spiacci et al 2008), suggesting that NO may have a dual role in the modulation of depression.…”

Substratos neurais envolvidos com o desenvolvimento do comportamento de desamparo em ratos: possível envolvimento do NO

“…No mesmo sentido, a administração de Larginina, substrato da NOS, é capaz de atenuar os efeitos do tipo antidepressivo da sertralina no FST (Inan et al, 2004), e o NO endógeno já foi descrito como capaz de diminuir as concentrações de serotonina no hipocampo (Wegener et al, 2000). Por último, Salchner e cols.…”