Dual Electrode Ensembles with Core and Shell Nanoelectrodes for Dopamine Sensing Applications

Abstract

This paper presents the fabrication of dual electrode ensembles for electrochemical sensing of dopamine. A new dual electrode ensemble consists of vertically aligned core nanowire electrodes and a shell electrode with a hemicylindrical nanocavity structure and submicron inter-electrode spacing between the two working electrodes. By using a 3-dimensional cavity structure of two working electrodes, collection efficiency in redox cycling of dopamine is enhanced. Initial measurement results show the ability to detect 200 mM concentration of dopamine with 69% collection efficiency on a dual electrode ensemble.

Electrochemical investigation of nano-electrodes for biomedical sensing applications in the brain

“…In the nanowire electrode design for neural sensing in [9][10][11], the distance between the nanowires was assumed to be 400 nm and the depth of the channels has the value of 1 µm in this study. For nanogrid electrode simulation, the gap between the sensing core and the shielding grid structures was set as 100 nm.…”

“…Here, an electrochemical molecular diffusion analysis using 2-dimensional finite element modeling is studied in relation with the electrode impedance property of nanoelectrodes. The analysis is based on our previous development of neural sensing electrodes using vertically aligned nanowires [9][10][11].…”

The controllable synthesis of orange-red emissive Au nanoclusters and their use as a portable colorimetric fluorometric probe for dopamine

“…3,4 In this regard, the detection of DA in human fluids is a critical requirement for the diagnosis of these diseases. Conventionally, many strategies, such as fluorescence spectrometry, 5 chromatography, 6 electrochemistry, 7,8 surface-enhanced Raman spectroscopy 9 and chemiluminescence, 10 have been adopted to determine the DA in human fluids. Among them, some conventional methods are restricted by the complicated pretreatment and time-consuming operation of the instruments, though the accuracy of detection is high.…”

Nanocavity Redox Cycling Sensors for the Detection of Dopamine Fluctuations in Microfluidic Gradients

“…The distinct advantages of confined redox cycling make this technique an interesting candidate for biosensing applications. − One application is the on-chip spatiotemporal detection of redox-active neurotransmitters with the prospect to investigate localized release of neurotransmitters from neuronal networks with high sensitivity. We have previously shown that nanofluidic redox cycling sensors are capable of detecting catechol, a precursor of the neurotransmitter dopamine, in a strong background of ascorbic acid .…”