Dual-Energy CT Perfusion of Invasive Tumor Front in Non–Small                     Cell Lung Cancers

Dewaguet, Julie; Copin, Marie‐Christine; Duhamel, Alain; Faivre, J; Deken, Valérie; Sedlmair, Martin; Flohr, Thomas; Schmidt, Bernhard; Cortot, A.; Wasielewski, E.; Rémy, Jacques; Rémy‐Jardin, Martine

doi:10.1148/radiol.2021210600

Cited by 14 publications

(4 citation statements)

References 32 publications

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“…6). One can foresee oncologic applications such as an improved insight into tumor neovascularization compared with that already achievable with traditional dual-energy CT. 31 Predicting the invasiveness of lung adenocarcinoma in a similar approach to that recently reported with high-spatial resolution 32 should be accessible to UHR. Disruption of air bronchiologram and a solid portion greater than 0.8 cm were found to be independently associated with a greater likelihood of invasiveness.…”

Section: Uhr For Chest Ct Angiographymentioning

confidence: 94%

Ultra-High-Resolution Photon-Counting CT Imaging of the Chest

et al. 2023

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After a decade of preclinical testing, photon-counting computed tomography (PCCT) has now entered daily routine, enabling radiologists to start investigating thoracic disorders in unprecedented conditions. The improved spatial resolution of the ultra-high-resolution (UHR) scanning mode is a major step for the analysis of bronchopulmonary disorders, making abnormalities at the level of small anatomical structures such as secondary pulmonary lobules accessible to radiologists. Distal divisions of pulmonary and systemic vessels also benefit from UHR protocols as alterations of lung microcirculation were previously excluded from confident analysis with energy-integrating detector CT. Although noncontrast chest CT examinations were the initial target of UHR protocols, the clinical value of this mode is also applicable to chest CT angiographic examinations with improved morphological evaluation and higher-quality lung perfusion imaging. The clinical benefits of UHR have been evaluated in initial studies, allowing radiologists to foresee the field of future applications, all combining high diagnostic value and radiation dose reduction. The purpose of this article is to highlight the technological information relevant to daily practice and to review the current clinical applications in the field of chest imaging.

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Section: Uhr For Chest Ct Angiographymentioning

confidence: 94%

Ultra-High-Resolution Photon-Counting CT Imaging of the Chest

et al. 2023

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“…Likewise, jatrorrhizine (50 μg) reduced tumor angiogenesis in BALB/C nude mice with xenografted metastatic melanoma cell C8161, probably because jatrorrhizine inhibited the expression of CDH5 [19] . Serine Protein Kinase (Traf2 and Nck-Interacting Kinase (TNIK)), in which Traf2 interacts with Nck, has been recognized as a vital activator of Wnt signaling pathway in promoting the progression and invasion of tumors [20] . Targeted knockout of TNIK in the human breast cancer cell line MDA-MB-231 revealed that the Wnt/β-catenin signaling pathway and the expression of EMT key proteins could be inhibited by destroying TNIK [11] .…”

Section: Groupingmentioning

confidence: 99%

Effects of Jatrorrhizine on Proliferation, Apoptosis and Invasion of Breast Cancer Cells by Regulating Wnt/Beta-Catenin Signaling Pathway

Wang¹

2023

IJPS

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To explore the effects of jatrorrhizine on proliferation, apoptosis, migration and invasion of breast cancer cells via the regulation of Wnt/β-catenin signaling pathway. Breast cancer cell line MDA-MB-468 was treated with varying concentrations of jatrorrhizine and then the effects of varying concentrations of jatrorrhizine on apoptosis of the cell were analyzed by flow cytometry. Western blotting was performed to test the protein expression of Wnt/beta-catenin signaling pathway. The breast cancer cells treated with 0 μM jatrorrhizine, breast cancer cells treated with 5 μM showed significant down-regulation in proliferation (p>0.05) and the breast cancer cells treated with 20 μM jatrorrhizine obviously decreased in proliferation activity, indicating the presence of statistical difference (p<0.05). The breast cancer cells treated with 0 μM jatrorrhizine and those treated with 5 μM showed an increase in apoptosis rate, the breast cancer cells treated with 20 μM jatrorrhizine obviously increased in apoptosis rate, indicating the presence of statistical difference (p<0.05). 0 μM group, the experiment of cell invasion and migration showed that 5 μM group experienced remarkable decline in the number of invasive and migratory cells vs. 0 μM group (p<0.05); and in this respect, 20 μM group had a marked decrease vs. 5 μM group, showing significant difference (p<0.05). In contrast with 0 μM group, apoptosis rate and B-cell lymphoma 2 expression level were observed to be an obvious decline and caspase-3 expression level presented an apparent increase in 5 μM group (p<0.05). In contrast with 5 μM group, apoptosis rate and B-cell lymphoma 2 expression level were observed to be an obvious decline and caspase-3 expression level presented an apparent increase in 20 μM group (p<0.05). After 48 h of treatment with jatrorrhizine, the beta-catenin expression in breast cancer cells was down-regulated in a concentrationdependent manner and whereas those of glycogen synthase kinase-3 and E-cadherin were up-regulated in a concentration-dependent manner, but that of interstitial marker protein N-cadherin in 5 μM group and 20 μM group was remarkably lower vs. 0 μM group. The regulation of Wnt/beta-catenin signaling pathway following the treatment of MDA-MB-468 with jatrorrhizine can promote apoptosis, inhibit proliferation and metastasis of breast cancer cells in a dose-dependent manner.

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“…In the past, some published works have tried to demonstrate the diagnostic role of DECT in neoplastic lung diseases [78][79][80][81][82][83][84][85].…”

Section: Lungmentioning

confidence: 99%

Thoracic Diseases: Technique and Applications of Dual-Energy CT

et al. 2023

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Dual-energy computed tomography (DECT) is one of the most promising technological innovations made in the field of imaging in recent years. Thanks to its ability to provide quantitative and reproducible data, and to improve radiologists’ confidence, especially in the less experienced, its applications are increasing in number and variety. In thoracic diseases, DECT is able to provide well-known benefits, although many recent articles have sought to investigate new perspectives. This narrative review aims to provide the reader with an overview of the applications and advantages of DECT in thoracic diseases, focusing on the most recent innovations. The research process was conducted on the databases of Pubmed and Cochrane. The article is organized according to the anatomical district: the review will focus on pleural, lung parenchymal, breast, mediastinal, lymph nodes, vascular and skeletal applications of DECT. In conclusion, considering the new potential applications and the evidence reported in the latest papers, DECT is progressively entering the daily practice of radiologists, and by reading this simple narrative review, every radiologist will know the state of the art of DECT in thoracic diseases.

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Dual-Energy CT Perfusion of Invasive Tumor Front in Non–Small Cell Lung Cancers

Cited by 14 publications

References 32 publications

Ultra-High-Resolution Photon-Counting CT Imaging of the Chest

Ultra-High-Resolution Photon-Counting CT Imaging of the Chest

Effects of Jatrorrhizine on Proliferation, Apoptosis and Invasion of Breast Cancer Cells by Regulating Wnt/Beta-Catenin Signaling Pathway

Thoracic Diseases: Technique and Applications of Dual-Energy CT

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