Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging

Ji, Xu; Zhang, Ran; Li, Ké; Chen, Guang‐Hong

doi:10.1109/tmi.2020.2990347

Cited by 10 publications

(8 citation statements)

References 75 publications

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“…5 Grating-based interferometry can be applicable at polychromatic x rays from compact Medical Physics, 48 (7), July 2021 laboratory sources and is more practical in terms of transferability to a clinical environment. 5,10,11 Additionally, quantitative electron density and material decomposition can also be realized by employing grating-based x-ray phase-contrast CT. [24][25][26] Among all available PCI techniques using synchrotron radiation, in-line PCI is the simplest to implement.…”

Section: Discussionmentioning

confidence: 99%

Phase retrieval‐based phase‐contrast CT for vascular imaging with microbubble contrast agent

Tang

Qin

et al. 2021

Medical Physics

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The introduction of microbubble contrast agent into tissues can create significant phase shifts. Phase retrieval (PR)-based phase-contrast computed tomography (PCCT) is an imaging method for retrieving and reconstructing the phase shifts within an object. This study aimed to evaluate the feasibility of PR-based PCCT with microbubble contrast agent for vascular imaging. Methods: Projection phase-contrast images of individual microbubbles and a cluster of microbubbles were captured and compared. Contrast enhancement from microbubbles was evaluated by comparing to the gold standard iodine-based contrast agent in vitro. The arterial systems of 14 Sprague-Dawley rats were perfused with microbubbles or saline. The rat hearts and the arterial systems were excised and imaged ex vivo. CT imaging was performed at the energy of 22 keV. PR was performed using the phase-attenuation duality (PAD) method with different δ/β values (PAD property). The contrast-to-noise ratio (CNR) was used for quantitatively assessing the contrast enhancement. Results: Individual microbubbles functioned as a lens to focus the x rays, whereas, a cluster of microbubbles scattered the x rays. In the in vitro experiment, the contrast enhancement from iodine was significantly greater than that from microbubbles (P < 0.05). In the heart samples, the CNRs for microbubbles on PR-based PCCT were significantly greater than those on absorption-contrast CT (ACCT) and PR-free PCCT (both P < 0.001). The CNRs for microbubbles were also significantly greater than those for saline on PR-based PCCT in the samples (P < 0.001). Although they provided weaker contrast enhancement than that from iodine, microbubbles could still provide sufficient contrast enhancement to clearly show the 3D architecture of rat aortas and their main branches. Conclusion:The imaging modality can currently be used as a complement or alternative to absorption-based microCT for imaging vessels in biological samples.

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Section: Discussionmentioning

confidence: 99%

Phase retrieval‐based phase‐contrast CT for vascular imaging with microbubble contrast agent

Tang

Qin

et al. 2021

Medical Physics

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“…While phase gratings are comparably easy to fabricate, absorption gratings for the relevant X-ray energies are challenging to fabricate as they need high attenuating lamellae at small periods [23,[134][135][136][137][138]. Photon counting detectors [139][140][141] and spectral detectors [142] are able to reduce noise in GBPC-CT and thus increase the electron density resolution [82,143].…”

Section: High Angular Sensitivity In Gbpc-ctmentioning

confidence: 99%

“…A further step is the combination of spectral detector information with GBPC-CT, which enables noise reduction and consequent increase in quantitative electron density resolution [ 143 ]. Latest results of laboratory GBPC-CT combined with a spectral detector with two energy bins improved contrast enhancement in three-material GBPC-CT decomposition [ 82 ].…”

Section: Applications Of Quantitative Gbpc-ctmentioning

confidence: 99%

“…In addition, Hounsfield units for the phase (HUp) [57,75] or the effective atomic number Z eff can be calculated [76][77][78]. The complementarity of the attenuation and phase signal of GBPC-CT can be used to perform material decomposition [79] or a decomposition similar to spectral CT into electron density and effective atomic number [80][81][82].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative X-ray phase contrast computed tomography with grating interferometry

Birnbacher

Braig

Pfeiffer

et al. 2021

Eur J Nucl Med Mol Imaging

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The ability of biomedical imaging data to be of quantitative nature is getting increasingly important with the ongoing developments in data science. In contrast to conventional attenuation-based X-ray imaging, grating-based phase contrast computed tomography (GBPC-CT) is a phase contrast micro-CT imaging technique that can provide high soft tissue contrast at high spatial resolution. While there is a variety of different phase contrast imaging techniques, GBPC-CT can be applied with laboratory X-ray sources and enables quantitative determination of electron density and effective atomic number. In this review article, we present quantitative GBPC-CT with the focus on biomedical applications.

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“…For instance, Qi et al 21 and Braig et al 22 used the single energy DPCT to achieve the two-basis material decomposition. Ji et al 23 accomplished a three-material decomposition by using a dual energy DPCT method. In this study, certain DECT scanning parameters and image decomposition algorithms are used to generate the electron density and effective atomic number maps from a dual-energy CT scan.…”

Section: Introductionmentioning

confidence: 99%

Performance evaluation of dual‐energy CT and differential phase contrast CT in quantitative imaging applications

Zhang

Yang

et al. 2022

Medical Physics

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The purpose of this study is to evaluate and compare the quantitative material decomposition performance of the dual-energy CT (DECT) and differential phase contrast CT (DPCT) via numerical observer studies. Methods: The electron density (𝜌 e ) and the effective atomic number (Z eff ) are selected as the decomposition bases. The image domain based decomposition algorithms with certain noise suppression are used to extract the 𝜌 e and Z eff information under three different spatial resolutions (0.3 mm, 0.1 mm, and 0.03 mm). The contrast-to-noise-ratio (CNR) and the numerical human observer model which is sensitive to the noise textures are investigated to compare the quantitative imaging performance of DECT and DPCT under varied radiation dose levels. Results:The model observer results show that the DECT is superior to DPCT at 0.3 mm spatial resolution (300 mm object size); the DECT and DPCT show similar quantitative imaging performance at 0.1 mm spatial resolution (100 mm object size); and the DPCT outperforms the DECT by approximately 1.5 times for the 0.3 mm sized imaging target at 0.03 mm spatial resolution (30 mm object size). Conclusions: In conclusion, the DECT would be recommended to obtain 𝜌 e and Z eff for the low spatial resolution quantitative imaging applications such as the diagnostic CT imaging. Whereas, the DPCT would be recommended for ultra high spatial resolution imaging tasks of small objects such as the micro-CT imaging. This study provides a reference to determine the most appropriate quantitative X-ray CT imaging method for a certain radiation dose level.

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Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging

Cited by 10 publications

References 75 publications

Phase retrieval‐based phase‐contrast CT for vascular imaging with microbubble contrast agent

Phase retrieval‐based phase‐contrast CT for vascular imaging with microbubble contrast agent

Quantitative X-ray phase contrast computed tomography with grating interferometry

Performance evaluation of dual‐energy CT and differential phase contrast CT in quantitative imaging applications

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