Dual-energy X-ray absorptiometry–based body volume measurement for 4-compartment body composition

Wilson, Joseph; Mulligan, Kathleen; Fan, Bo; Sherman, Jennifer; Murphy, Elizabeth J.; Tai, Viva; Powers, Cassidy; Márquez, Lorena; Ruiz-Barros, Viviana; Shepherd, John

doi:10.3945/ajcn.111.019273

Cited by 50 publications

(44 citation statements)

References 23 publications

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“…Polyoxymethylene has been shown previously to be a good candidate for representing the x-ray attenuation properties of protein. 17,41 The calculated linear attenuation curves based on the molecular structure of the materials involved in this study are presented in Fig. 2, where a good agreement between protein and polyoxymethylene can be found in the energy range under investigation.…”

Section: Iib Experimental Calibration and Tissue Sample Preparationmentioning

confidence: 99%

Measurement of breast tissue composition with dual energy cone‐beam computed tomography: A postmortem study

2013

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Purpose:To investigate the feasibility of a three-material compositional measurement of water, lipid, and protein content of breast tissue with dual kVp cone-beam computed tomography (CT) for diagnostic purposes. Methods: Simulations were performed on a flat panel-based computed tomography system with a dual kVp technique in order to guide the selection of experimental acquisition parameters. The expected errors induced by using the proposed calibration materials were also estimated by simulation. Twenty pairs of postmortem breast samples were imaged with a flat-panel based dual kVp cone-beam CT system, followed by image-based material decomposition using calibration data obtained from a three-material phantom consisting of water, vegetable oil, and polyoxymethylene plastic. The tissue samples were then chemically decomposed into their respective water, lipid, and protein contents after imaging to allow direct comparison with data from dual energy decomposition. Results: Guided by results from simulation, the beam energies for the dual kVp cone-beam CT system were selected to be 50 and 120 kVp with the mean glandular dose divided equally between each exposure. The simulation also suggested that the use of polyoxymethylene as the calibration material for the measurement of pure protein may introduce an error of −11.0%. However, the tissue decomposition experiments, which employed a calibration phantom made out of water, oil, and polyoxymethylene, exhibited strong correlation with data from the chemical analysis. The average root-mean-square percentage error for water, lipid, and protein contents was 3.58% as compared with chemical analysis. Conclusions:The results of this study suggest that the water, lipid, and protein contents can be accurately measured using dual kVp cone-beam CT. The tissue compositional information may improve the sensitivity and specificity for breast cancer diagnosis.

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Section: Iib Experimental Calibration and Tissue Sample Preparationmentioning

confidence: 99%

Measurement of breast tissue composition with dual energy cone‐beam computed tomography: A postmortem study

2013

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“…Saliva samples were frozen for later batch analysis. The samples were processed in duplicate for measurement of deuterium enrichment by wavelength-scanned cavity ringdown spectroscopy (Isotopic Water Analyzer, L2120-I; Picarro), and TBW was calculated as previously described (33).…”

Section: Tbw By 2 H 2 Omentioning

confidence: 99%

Comparison of multiple methods to measure maternal fat mass in late gestation

Marshall

Murphy

King³

et al. 2016

The American Journal of Clinical Nutrition

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Background: Measurements of maternal fat mass (FM) are important for studies of maternal and fetal health. Common methods of estimating FM have not been previously compared in pregnancy with measurements using more complete body composition models. Objectives: The goal of this pilot study was to compare multiple methods that estimate FM, including 2-, 3-and 4-compartment models in pregnant women at term, and to determine how these measures compare with FM by dual-energy X-ray absorptiometry (DXA) 2 wk postpartum. Design: Forty-one healthy pregnant women with prepregnancy body mass index (in kg/m 2 ) 19 to 46 underwent skinfold thickness (SFT), bioelectrical impedance analysis (BIA), body density (D b ) via air displacement plethysmography (ADP), and deuterium dilution of total body water (TBW) with and without adjustments for gestational age using van Raaij (VRJ) equations at 37-38 wk of gestation and 2 wk postpartum to derive 8 estimates of maternal FM. Deming regression analysis and Bland-Altman plots were used to compare methods of FM assessment. Results: Systematic differences in FM estimates were found. Methods for FM estimates from lowest to highest were 4-compartment, DXA, TBW (VRJ) , 3-compartment, D b(VRJ) , BIA, air displacement plethysmography body density, and SFT ranging from a mean 6 SD of 29.5 6 13.2 kg via 4-compartment to 39.1 6 11.7 kg via SFT. Compared with postpartum DXA values, Deming regressions revealed no substantial departures from trend lines in maternal FM in late pregnancy for any of the methods. The 4-compartment method showed substantial negative (underestimating) constant bias, and the air displacement plethysmography body density and SFT methods showed positive (overestimating) constant bias. ADP via D b(VRJ) and 3-compartment methods had the highest precision; BIA had the lowest. Conclusions: ADP that uses gestational age-specific equations may provide a reasonable and practical measurement of maternal FM across a spectrum of body weights in late pregnancy. SFT would be acceptable for use in larger studies. This trial was registered at clinicaltrials.gov as NCT02586714.

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“…16,51 Two holes, with a diameter of 0.95 cm, were drilled in the phantom and were subsequently filled with water and vegetable oil. Thus, the three-compartment phantom consisted of surrogate materials for water, lipid, and protein, in terms of their x-ray attenuation properties, respectively.…”

Section: B Calibration Phantom and Postmortem Breast Samplesmentioning

confidence: 99%

Breast tissue decomposition with spectral distortion correction: A postmortem study

et al. 2014

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Purpose: To investigate the feasibility of an accurate measurement of water, lipid, and protein composition of breast tissue using a photon-counting spectral computed tomography (CT) with spectral distortion corrections. Methods: Thirty-eight postmortem breasts were imaged with a cadmium-zinc-telluride-based photon-counting spectral CT system at 100 kV. The energy-resolving capability of the photon-counting detector was used to separate photons into low and high energy bins with a splitting energy of 42 keV. The estimated mean glandular dose for each breast ranged from 1.8 to 2.2 mGy. Two spectral distortion correction techniques were implemented, respectively, on the raw images to correct the nonlinear detector response due to pulse pileup and charge-sharing artifacts. Dual energy decomposition was then used to characterize each breast in terms of water, lipid, and protein content. In the meantime, the breasts were chemically decomposed into their respective water, lipid, and protein components to provide a gold standard for comparison with dual energy decomposition results. Results: The accuracy of the tissue compositional measurement with spectral CT was determined by comparing to the reference standard from chemical analysis. The averaged root-mean-square error in percentage composition was reduced from 15.5% to 2.8% after spectral distortion corrections. Conclusions:The results indicate that spectral CT can be used to quantify the water, lipid, and protein content in breast tissue. The accuracy of the compositional analysis depends on the applied spectral distortion correction technique. C 2014 American Association of Physicists in Medicine. [http://dx

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Dual-energy X-ray absorptiometry–based body volume measurement for 4-compartment body composition

Cited by 50 publications

References 23 publications

Measurement of breast tissue composition with dual energy cone‐beam computed tomography: A postmortem study

Measurement of breast tissue composition with dual energy cone‐beam computed tomography: A postmortem study

Comparison of multiple methods to measure maternal fat mass in late gestation

Breast tissue decomposition with spectral distortion correction: A postmortem study

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