Dual-Energy X-Ray Absorptiometry Study of Body Composition in Patients With Lipodystrophy

Valério, Cynthia Melissa; Godoy-Matos, Amélio F.; Moreira, Rodrigo O.; Carraro, Lucia; Guedes, Erika Paniago; Moisés, Regina S.; Mory, Patrícia B.; Souza, Luciana Lopes de; Russo, Luís Augusto Tavares; Melazzi, Ana Cláudia C.

doi:10.2337/dc07-0025

Cited by 17 publications

(13 citation statements)

References 13 publications

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“…We previously reported the use of FMR for identification of all lipodystrophy phenotypes in a smaller series of patients [8]. Now, we have increased the number of studied patients and limited it to FLPD.…”

Section: Discussionmentioning

confidence: 99%

“…Central to peripheral fat Ratio (or Fat Mass Ratio [FMR]) was used to investigate body fat distribution [8,9]. Whole body DXA scans were obtained using manufacturer’s recommendation for subject positioning, scan protocols and scan analysis.…”

Section: Methodsmentioning

confidence: 99%

“…To date few studies have compared regional fat distribution in FPLD, most using Computed Tomography or Magnetic Resonance Images [5-7], which are not applicable for clinical practice. We have previously suggested that DXA might be a tool for this purpose [8,9]. …”

Section: Introductionmentioning

confidence: 99%

“…We previously reported the use of FMR in distinct forms of lipodystrophy phenotypes, non-related to HIV infection [8,9]. Now, we have increased the number of studied patients and limited it to Familial Partial Lipodystrophy (FPLD).…”

Section: Introductionmentioning

confidence: 99%

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Body composition study by dual-energy x-ray absorptiometry in familial partial lipodystrophy: finding new tools for an objective evaluation

Valério

Zajdenverg

Oliveira

et al. 2012

Diabetol Metab Syndr

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BackgroundFamilial partial lipodystrophies (FPLD) are clinically heterogeneous disorders characterized by selective loss of adipose tissue, insulin resistance and metabolic complications. Until genetic studies become available for clinical practice, clinical suspicion and pattern of fat loss are the only parameters leading clinicians to consider the diagnosis. The objective of this study was to compare body composition by dual energy X-ray absorptiometry (DXA) in patients with FPLD and control subjects, aiming to find objective variables for evaluation of FPLD.MethodsEighteen female patients with partial lipodystrophy phenotype and 16 healthy controls, matched for body mass index, sex and age were studied. All participants had body fat distribution evaluated by DXA measures. Fasting blood samples were obtained for evaluation of plasma leptin, lipid profile and inflammatory markers. Genetic studies were carried out on the 18 patients selected that were included for statistical analysis. Thirteen women confirmed diagnosis of Dunnigan-type FPLD (FPLD2).ResultsDXA revealed a marked decrease in truncal fat and 3 folds decrease in limbs fat percentage in FPLD2 patients (p <0.001). Comparative analysis showed that ratio between trunk and lower limbs fat mass, characterized as Fat Mass Ratio (FMR), had a greater value in FLPD2 group (1.86 ± 0.43 vs controls 0.93 ± 0.10; p <0.001) and a improved accuracy for evaluating FPLD2 with a cut-off point of 1.2. Furthermore, affected women showed hypoleptinemia (FLPD2 4.9 ± 2.0 vs controls 18.2 ± 6.8; p <0.001), insulin resistance and a more aggressive lipid profile.ConclusionIn this study, assessment of body fat distribution by DXA permitted an objective characterization of FLPD2. A consistent pattern with marked fat reduction of lower body was observed in affected patients. To our knowledge this is the first time that cut-off values of objective variables were proposed for evaluation of FPLD2.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Body composition study by dual-energy x-ray absorptiometry in familial partial lipodystrophy: finding new tools for an objective evaluation

Valério

Zajdenverg

Oliveira

et al. 2012

Diabetol Metab Syndr

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“…We have previously characterized body fat distribution by DXA in patients with generalized and partial lipodystrophy and have demonstrated that a central to peripheral fat ratio, named fat mass ratio (FMR) [10, 11] and BAI [12], may be useful to investigate fat distribution in these patients [10–12]. Our main results were that individuals with FPLD2 do have increased levels of DDP4 and that these levels might correlate with body fat distribution measured by DXA and estimated by BAI.…”

Section: Discussionmentioning

confidence: 99%

Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2

Valério

Almeida

Moreira

et al. 2017

Diabetol Metab Syndr

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BackgroundDipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism.ObjectiveThe aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2) and correlate it with body fat distribution.MethodsFourteen patients with FPLD2 were selected to participate in this study and matched to a healthy control group (n = 8). All participants had anthropometrical data registered. Body adiposity index (BAI) was used to evaluate fat distribution in this population. Body fat content and distribution were analyzed by dual X-ray absorptiometry (DXA). Biochemical exams, including DPP4 levels, were performed in all individuals.ResultsDespite the same body mass index, lipodystrophic patients had a significant lower hip (median 92.0 vs 94.5; p = 0.028), HDL cholesterol (42.6 ± 10.4 vs 66.1 ± 16.0; p < 0.01) and BAI (24.1 ± 2.8 vs 29.0 ± 3.7; p = 0.02), suggesting that BAI was able to catch differences in fat distribution between groups. On the other hand, patients with FPLD2 presented significant higher levels of insulin (median 11.2 vs 5.3; p = 0.015), triglycerides (184.9 ± 75.4 vs 89.1 ± 51.0; p < 0.01) and DPP4 (4.89 ± 0.92 vs 3.93 ± 1.08; p = 0.04). A trend toward an inverse statistical significance was observed between DPP4 levels and BAI (r = −0.38; p = 0.072). In the lipodistrophic group, a significant correlation was found between DPP4 levels and percentage of total body fat (r = 0.86; p = 0.0025) and android fat (r = 0.78; p = 0.014).ConclusionsPatients with FPLD2 exhibit an increase in DDP4 levels in comparison to a healthy control group. The increase in the levels of this enzyme does not seem to be related to the diagnosis of diabetes and might be associated with an increase in central fat (estimated using BAI and measured using DXA). These results might be used to reinforce the concept that DDP4 is an adipokine related to central fat distribution.

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Current literature in diabetes

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Dual-Energy X-Ray Absorptiometry Study of Body Composition in Patients With Lipodystrophy

Cited by 17 publications

References 13 publications

Body composition study by dual-energy x-ray absorptiometry in familial partial lipodystrophy: finding new tools for an objective evaluation

Body composition study by dual-energy x-ray absorptiometry in familial partial lipodystrophy: finding new tools for an objective evaluation

Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2

Current literature in diabetes

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