Dual exposure to stress in different stages of development affects eating behavior of male Wistar rats

Souza, Julliet Araújo de; Almeida, Larissa Cavalcanti do Amaral; Tavares, Gabriel Araújo; Falcão, Lívia de Almeida Lira; Beltrão, Luana Cruz; Costa, Fernanda Cicalese Ourem; Souza, Felipe Leitão de; Silva, Matilde Cesiana da; Souza, Sandra Lopes de

doi:10.1016/j.physbeh.2019.112769

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…Previous studies from our laboratory show that the MS disrupts the 5HT system. In middle aged females, it increases the 5HT1B gene expression in the hypothalamus, associated with decreased food intake ( de Souza et al, 2020a ), and in adult males, we observed a decreased action of fluoxetine on food intake ( de Souza et al, 2020b ). In addition, MS promotes decreased 5HT concentration in hypothalamus and amygdala of young animals, associated with increased palatable food intake ( de Lima et al, 2020 ).…”

Section: Serotonin: Role On Feeding Behavior Influences Of Els and mentioning

confidence: 65%

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

2020

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Section: Serotonin: Role On Feeding Behavior Influences Of Els and mentioning

confidence: 65%

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

2020

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“…The EPM test is based on the aversion to open and high spaces of the rodents and is a classic test for assessing anxiety-like behaviors ( Pellow et al, 1985 ; de Souza et al, 2020b ). The EPM is made of wood, with two closed arms (50 cm × 10 cm × 40 cm) perpendicular to two open arms (50 cm × 10 cm), besides a central area (10 cm × 10 cm), raised 50 cm high from the floor.…”

Section: Methodsmentioning

confidence: 99%

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Leal

Silva

Rocha-Gomes

et al. 2022

Front. Behav. Neurosci.

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High-salt (HS) diets have recently been linked to oxidative stress in the brain, a fact that may be a precursor to behavioral changes, such as those involving anxiety-like behavior. However, to the best of our knowledge, no study has evaluated the amygdala redox status after consuming a HS diet in the pre- or postweaning periods. This study aimed to evaluate the amygdala redox status and anxiety-like behaviors in adulthood, after inclusion of HS diet in two periods: preconception, gestation, and lactation (preweaning); and only after weaning (postweaning). Initially, 18 females and 9 male Wistar rats received a standard (n = 9 females and 4 males) or a HS diet (n = 9 females and 5 males) for 120 days. After mating, females continued to receive the aforementioned diets during gestation and lactation. Weaning occurred at 21-day-old Wistar rats and the male offspring were subdivided: control-control (C-C)—offspring of standard diet fed dams who received a standard diet after weaning (n = 9–11), control-HS (C-HS)—offspring of standard diet fed dams who received a HS diet after weaning (n = 9–11), HS-C—offspring of HS diet fed dams who received a standard diet after weaning (n = 9–11), and HS-HS—offspring of HS diet fed dams who received a HS diet after weaning (n = 9–11). At adulthood, the male offspring performed the elevated plus maze and open field tests. At 152-day-old Wistar rats, the offspring were euthanized and the amygdala was removed for redox state analysis. The HS-HS group showed higher locomotion and rearing frequency in the open field test. These results indicate that this group developed hyperactivity. The C-HS group had a higher ratio of entries and time spent in the open arms of the elevated plus maze test in addition to a higher head-dipping frequency. These results suggest less anxiety-like behaviors. In the analysis of the redox state, less activity of antioxidant enzymes and higher levels of the thiobarbituric acid reactive substances (TBARS) in the amygdala were shown in the amygdala of animals that received a high-salt diet regardless of the period (pre- or postweaning). In conclusion, the high-salt diet promoted hyperactivity when administered in the pre- and postweaning periods. In animals that received only in the postweaning period, the addition of salt induced a reduction in anxiety-like behaviors. Also, regardless of the period, salt provided amygdala oxidative stress, which may be linked to the observed behaviors.

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“…Downregulated genes in the perilesional cortex as compared to the corresponding cortical area of the sham-operated aged rats, included genes like dopamine receptor D1A ( Drd1a ) involved in feeding behavior ( de Souza et al, 2020 ) and depression ( Amiri et al, 2016 ), glutamate decarboxylase (Gad1) and solute carrier family 5 member D ( Slc5d3 ) involved in neuronal development ( Lu et al, 2014 ), schizophrenia ( Tao et al, 2018 ) and autophagy ( Wei et al, 2016 ) as well as ubiquitin specific peptidase 11 ( Usp11 )( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats

et al. 2020

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The major aim of stroke therapies is to stimulate brain repair and to improve behavioral recuperation after cerebral ischemia. Despite remarkable advances in cell therapy for stroke, stem cell-based tissue replacement has not been achieved yet stimulating the search for alternative strategies for brain self-repair using the neurogenic zones of the brain, the dentate gyrus and the subventricular zone (SVZ). However, during aging, the potential of the hippocampus and the SVZ to generate new neuronal precursors, declines. We hypothesized that electrically stimulation of endogenous neurogenesis in aged rats could increase the odds of brain self-repair and improve behavioral recuperation after focal ischemia. Following stroke in aged animals, the rats were subjected to two sessions of electrical non-convulsive stimulation using ear-clip electrodes, at 7- and 24 days after MCAO. Animal were sacrificed after 48 days. We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze) but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the gene that were unique to ES, we noted increases in the expression of seizure related 6 homolog like which is one of the physiological substrate of the β-secretase BACE1 involved in the pathophysiology of the Alzheimer’s disease and Igfbp3 and BDNF receptor mRNAs which has been shown to have a neuroprotective effect after cerebral ischemia. However, ES was associated with a long-term down regulation of cortical gene expression after stroke in aged rats suggesting that gene expression in the peri-infarcted cortical area may not be related to electrical stimulation induced-neurogenesis in the subventricular zone and hippocampus.

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Dual exposure to stress in different stages of development affects eating behavior of male Wistar rats

Cited by 8 publications

References 37 publications

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats

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