Dual-frequency High Intensity Focused Ultrasound (HIFU) Accelerating Therapy

He, Ronghai; Shou, Wende; Duan, Shimei; Xia, Ronghui

doi:10.1109/iembs.2005.1616381

Cited by 12 publications

(14 citation statements)

References 14 publications

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“…7-11). The results in [7] are collected, where a dual-frequency ablation with 20 kHz frequency difference was adopted. It was believed that a multi-frequency wave would lead to a decrease in the cavitation threshold if a low-frequency wave (e.g., 20 kHz) was introduced [7].…”

Section: F Discussionmentioning

confidence: 99%

“…The results in [7] are collected, where a dual-frequency ablation with 20 kHz frequency difference was adopted. It was believed that a multi-frequency wave would lead to a decrease in the cavitation threshold if a low-frequency wave (e.g., 20 kHz) was introduced [7]. nevertheless, according to our findings, cavitation may still be triggered more efficiently in multi-frequency ablation, even though the frequency difference is as high as 1.8 MHz.…”

Section: F Discussionmentioning

confidence: 99%

“…1(b)], with the positions of transducers being the same as those in the experimental setup mentioned subsequently. although the former case has been extensively studied in recent research [7], the latter configuration is the focus of this study and we show that it could shed light on the mechanism of multi-frequency HIFU ablations.…”

Section: A Multi-frequency Ultrasound Simulationmentioning

confidence: 97%

“…Hence, a tissue lesion is formed. although there are still many on-going discussions of other possible HIFU ablation mechanisms, the broadly accepted tissue ablation theory is that biologic effects of HIFU on the targeted tumor are the combination of both thermal effects and cavitation effects [7].…”

Section: Introductionmentioning

confidence: 99%

“…To obtain tissue ablation with enlarged lesion volume and steeper temperature rise, multifrequency ultrasound has been studied in recent years. The dual-frequency tissue ablation experiments were carried out by simultaneously irradiating porcine liver regions of interest with confocal ultrasound transducers at 1.563 MHz and 1.573 MHz [7], where the frequency difference is 10 kHz. It was found that dual-frequency HIFU induced larger lesions than conventional single-frequency HIFU under the same power density, which was likely a result of the enhanced cavitation in the case of dualfrequency ultrasound.…”

Section: Introductionmentioning

confidence: 99%

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Temperature rise in tissue ablation using multi-frequency ultrasound

Guo

Jing

Jiang

2013

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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High-intensity focused ultrasound (HIFU) is becoming an increasingly important noninvasive surgical tool, despite the challenges in temperature rise control and unwanted heating problems. In this study, experiments and simulations on tissue ablation effectiveness were performed using multi-frequency HIFU with frequency differences of more than 500 kHz (center frequencies are 950 kHz, 1.5 MHz, and 3.3 MHz). In the experiments, the temperature was recorded as chicken breast tissue was heated by single-frequency, dual-frequency, and tri-frequency HIFU configurations at controlled acoustic power and exposure time. 5% to 10% temperature rise differences were observed between single- and multi-frequency modes, indicating that multi-frequency HIFU is more effective at producing faster temperature rises. Cavitation detection tests were conducted to compare the cavitation pressure fields between single- and multi-frequency ultrasound. Moreover, simulations on single-frequency and multi-frequency acoustic fields as well as bio-heating-induced temperature fields were performed. With the comparison between experimental and simulation results, we believe that the more effective tissue ablation using multi-frequency ultrasound is likely attributed to the enhanced cavitation, a promising result for HIFU applications.

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Section: F Discussionmentioning

confidence: 99%

Section: F Discussionmentioning

confidence: 99%

Section: A Multi-frequency Ultrasound Simulationmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Temperature rise in tissue ablation using multi-frequency ultrasound

Guo

Jing

Jiang

2013

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Effect of pulse parameters on ablation efficiency in dual-frequency HIFU therapy

Zhu

Liu

et al. 2023

Ultrasonics

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Dual-Focus Therapeutic Ultrasound Transducer for Production of Broad Tissue Lesions

Jeong

Cannata

Shung

2010

Ultrasound in Medicine & Biology

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In noninvasive high-intensity focused ultrasound (HIFU) treatment, formation of a large tissue lesion per sonication is desirable for reducing the overall treatment time. The goal of this study is to show the feasibility of enlarging tissue lesion size with a dual-focus therapeutic ultrasound transducer (DFTUT) by increasing the depth-of-focus (DOF). The proposed transducer consists of a disc- and an annular-type element of different radii of curvatures to produce two focal zones. To increase focal depth and to maintain uniform beamwidth of the elongated DOF, each element transmits ultrasound of a different center frequency: the inner element at a higher frequency for near field focusing and the outer element at a lower frequency for far field focusing. By activating two elements at the same time with a single transmitter capable of generating a dual-frequency mixed signal, the overall DOF of the proposed transducer may be extended considerably. A prototype transducer composed of a 4.1 MHz inner element and a 2.7 MHz outer element was fabricated to obtain preliminary experimental results. The feasibility the proposed technique was demonstrated through sound field, temperature and thermal dose simulations. The performance of the prototype transducer was verified by hydrophone measurements and tissue ablation experiments on a beef liver specimen. When several factors affecting the length and the uniformity of elongated DOF of the DFTUT are optimized, the proposed therapeutic ultrasound transducer design may increase the size of ablated tissues in the axial direction and, thus, decreasing the treatment time for a large volume of malignant tissues especially deep-seated targets.

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Dual-frequency High Intensity Focused Ultrasound (HIFU) Accelerating Therapy

Cited by 12 publications

References 14 publications

Temperature rise in tissue ablation using multi-frequency ultrasound

Temperature rise in tissue ablation using multi-frequency ultrasound

Effect of pulse parameters on ablation efficiency in dual-frequency HIFU therapy

Dual-Focus Therapeutic Ultrasound Transducer for Production of Broad Tissue Lesions

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