Dual function of activated PPARγ by ligands on tumor growth and immunotherapy

Chen, Mingjun; Wang, Huijie; Cui, Qian; Shi, Juanjuan; Hou, Yongzhong

doi:10.1007/s12032-024-02363-z

Med Oncol

2024

DOI: 10.1007/s12032-024-02363-z

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Dual function of activated PPARγ by ligands on tumor growth and immunotherapy

Mingjun Chen,

Huijie Wang,

Qian Cui

et al.

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Cited by 5 publications

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Chronic inflammation poses challenges to effective cancer treatment. Although anti‐inflammatory therapies have shown short‐term benefits, their long‐term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro‐resolving mediators, which play a role in modulating the cancer microenvironment by promoting the resolution of initiated inflammatory processes and restoring tissue hemostasis. This review addresses current insights into how inflammation contributes to cancer pathogenesis and explores recent strategies to resolve inflammation associated with cancer.

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Dual function of activated PPARγ by ligands on tumor growth and immunotherapy

Cited by 5 publications

References 83 publications

PPARα phosphorylation regulates colorectal tumor immune escape

PPARα phosphorylation regulates colorectal tumor immune escape

Traditional Chinese Medicine formulas-based interventions on colorectal carcinoma prevention: The efficacies, mechanisms and advantages

Resolution of chronic inflammation and cancer

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