Dual functional cholinesterase inhibitors and complexing of aluminum ions of five species of fungi family depended of drying conditions and extraction process - In vitro study

Zawadzka, Agnieszka; Kobus‐Cisowska, Joanna; Szwajgier, Dominik; Szczepaniak, Oskar; Szulc, Piotr; Siwulski, Marek

doi:10.1016/j.lwt.2021.112712

Cited by 4 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentration of phenolic compounds from Ganoderma and other fungal species was attributed to AChE inhibition by many authors [62][63][64][65][66]. Hence, differences in the inhibition of AChE observed in our study between the two Ganoderma species may be linked to variations in their secondary metabolite profiles, since the G. applanatum extract demonstrated twice the TPC compared to the extract of G. resinaceum, which did not exhibit anti-AChE activity at the tested concentration.…”

Section: Ache Inhibitory Potentialmentioning

confidence: 50%

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

Rašeta,

Kebert,

Mišković

et al. 2023

JoF

View full text Add to dashboard Cite

The therapeutic effectiveness of current neurodegenerative disease treatments is still under debate because of problems with bioavailability and a range of side effects. Fungi, which are increasingly recognized as sources of natural antioxidants and acetylcholinesterase (AChE) enzyme inhibitors, may thus serve as potent neuroprotective agents. Previous studies have associated the anti-AChE and antioxidant activities of fungi mostly with polysaccharides and phenolic compounds, while other secondary metabolites such as polyamines (PAs) have been neglected. This study aimed to investigate eight edible and medicinal fungi from Serbia, marking the initial investigation into the neuroprotective capabilities of Postia caesia, Clitocybe odora, Clitopilus prunulus, and Morchella elata. Neuroprotective activity was examined using the Ellman assay, while the antioxidant capacity was tested by conducting DPPH, NO, ABTS, and FRAP tests. PA levels were determined by high-performance liquid chromatography (HPLC) coupled with fluorescent detection. Ganoderma applanatum and Lepista nuda exhibited the most robust anti-AChE (98.05 ± 0.83% and 99.94 ± 3.10%, respectively) and antioxidant activities, attributed to the synergistic effects of the total protein, total phenolic, and PA levels. Furthermore, P. caesia displayed significant AChE inhibition (88.21 ± 4.76%), primarily linked to the elevated spermidine (SPD) (62.98 ± 3.19 mg/kg d.w.) and putrescine (PUT) levels (55.87 ± 3.16 mg/kg d.w.). Our results highlight the need for thorough research to comprehend the intricate relationships between distinct fungus species and AChE inhibition. However, it is important to recognize that more research is required to identify the precise substances causing the reported inhibitory effects.

show abstract

Section: Ache Inhibitory Potentialmentioning

confidence: 50%

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

Rašeta,

Kebert,

Mišković

et al. 2023

JoF

View full text Add to dashboard Cite

show abstract

“…Zawadzka et al 159 reported that the methanol extract of convective-dried CC resulted in an inhibitory activity of 10.75 ± 3.75% on AChE, with no effect on BuChE, whereas methanol extract of freeze-dried CC led to an inhibitory activity of 9.76 ± 3.03% on BuChE, with no effect on AChE. 159 In addition to the inhibition of cholinesterase activity, Lemieszek et al 160 demonstrated that two CC polysaccharides, CC2a and CC3 1 , were capable of enhancing neuronal activity and promoting neurite outgrowth, thereby exerting neuroprotective effects. At a concentration of 100 μg mL −1 , CC2a and CC3 1 significantly increased the metabolic activity, reduced LDH levels of neurons, and promoted neurite outgrowth ( p < 0.001).…”

Section: Neuroprotective Activitymentioning

confidence: 99%

“…The ability of CC to inhibit AChE and BuChE also depends on different drying processes. Zawadzka et al 159 reported that the methanol extract of convective-dried CC resulted in an inhibitory activity of 10.75 ± 3.75% on AChE, with no effect on BuChE, whereas methanol extract of freeze-dried CC led to an inhibitory activity of 9.76 ± 3.03% on BuChE, with no effect on AChE. 159…”

Section: Health-promoting Effects Of Cantharellus Cibariusmentioning

confidence: 99%

Insights into chemical components, health-promoting effects, and processing impact of golden chanterelle mushroom Cantharellus cibarius

Chen,

2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Effects of antimicrobial nanocomposite films packaging on the postharvest quality and spoilage bacterial communities of mushrooms (Chanterelles)

Jiang,

Zhu,

Liu

et al. 2023

Food Chemistry: X

View full text Add to dashboard Cite

Dual functional cholinesterase inhibitors and complexing of aluminum ions of five species of fungi family depended of drying conditions and extraction process - In vitro study

Cited by 4 publications

References 29 publications

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

Insights into chemical components, health-promoting effects, and processing impact of golden chanterelle mushroom Cantharellus cibarius

Effects of antimicrobial nanocomposite films packaging on the postharvest quality and spoilage bacterial communities of mushrooms (Chanterelles)

Contact Info

Product

Resources

About