Dual functions of epigallocatechin gallate surface-modified Au nanorods@selenium composites for near-infrared-II light-responsive synergistic antibacterial therapy

Abstract

Diseases caused by bacterial infections pose ever-increasing threats to human health, making it important to explore alternative antibacterial strategies. Herein, epigallocatechin gallate (EGCG) surface-modified Au nanorods@selenium composites (ASE NPs) were developed for synergistic NIR-II light-responsive antibacterial therapy. In vitro antibacterial experiments demonstrated the improved antibacterial effect of ASE NPs against Staphylococcus aureus ( S. aureus) compared with EGCG alone. In addition, in vivo studies demonstrated that ASE NPs cured skin wound infections and sepsis in mice caused by S. aureus. Au nanorods with excellent photothermal conversion realized synergistic photothermal therapy (PTT) in the NIR-II biowindow with an improved penetration depth at a low power density. More importantly, toxicity analysis showed that the composites had no toxic effects on major organs. Thus, the EGCG surface-modified Au nanorods@selenium composites with an NIR-II light-responsive synergistic activity hold great promise for the effective treatment of drug-resistant bacterial infections.

Photothermal Ferrotherapy – Induced Immunogenic Cell Death via Iron‐Based Ternary Chalcogenide Nanoparticles Against Triple‐Negative Breast Cancer

“…Subsequently, the natural cooling process of AgFeS 2 NPs was recorded after switching off the laser (Figure 2E). According to the literature, [ 30 ] the heat conversion efficiency ( η ) of the AgFeS 2 NPs was 27% (Figure 2F), which is close to that of other reported ion‐based NPs such as Fe 3 O 4 (33.1%), [ 31 ] FeS (34%), [ 32 ] MnFe 2 O 4 (20%), [ 33 ] and CuFeS 2 (18%), [ 34 ] as well as noble metal‐based NPs such as Au nanorods (22%), [ 35 ] Pd@Au nanoplates (28%), [ 36 ] and Au nanoshell (13%). [ 37 ] Therefore, these desirable properties make AgFeS 2 NPs promising as photothermal agents for PTT.…”

Polyethyleneimine surface-modified silver-selenium nanocomposites for anti-infective treatment of wounds by disrupting biofilms

“…The inhibitory effect of ASP NCs on S. aureus and the promotion of healing of infected wounds were explored by establishing mice wound infection model [34] (figure 3(A)). Wound healing photographs and the size of the healed area were recorded for the different treatment groups at 2, 4, 6, and 10 after postoperative days (figures 3(B) and (C)).…”