This paper discusses progress and issues related to amorphous oxide semiconductors (AOS) thin film transistors (TFTs) for flat panel display and imaging applications. In particular, we review the dark-and wavelength-dependent photo-instability in AOS TFTs and its origins, along with the density of states (DOS) profile in these materials, including the role of oxygen vacancies. The relative dominance of trap-limited conduction (TLC) and percolation depending on gate voltage is presented. The effects of photo-instability and specifically persistent photoconductivity (PPC) arising from ionized oxygen vacancies is examined using results of stress/recovery measurements. Based on this, techniques to overcome the PPC are presented, and includes a dual gate photo-TFT structure with appropriate pulse biasing.