Dual hit – Magnetic resonance imaging in concomitant anterior and posterior ischemic optic neuropathy in a case of rhino-orbital mucormycosis and COVID-19

Kaushik, Kavya S.; Acharya, Ullas V; Krupa, Lakshmi

doi:10.4103/ijo.ijo_1312_21

Cited by 4 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 38 ] Kaushik et al . [ 39 ] reported a unique case with concomitant anterior and posterior ischemic optic neuropathy where posterior ischemic optic neuropathy was diagnosed on diffusion-weighted MRI scans even when clinical signs were absent, thereby being advantageous as posterior ischemic optic neuropathy was otherwise a diagnosis of exclusion.…”

Section: Investigationsmentioning

confidence: 99%

Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review

Karkhur

Soni

Chauhan

et al. 2022

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

This study aimed to review the current literature for epidemiology, pathogenesis, clinical spectrum and management of rhino-orbito-cerebral-mucormycosis (ROCM), especially highlighting the association between ROCM and COVID-19 disease and factors resulting in its resurgence during the pandemic. Mucormycosis is a rare, but an important emerging opportunistic fungal infection, often associated with high morbidity and mortality. ROCM is the commonest and also the most aggressive clinical form occurring in debilitated patients in conjunction with sinus or para-sinus involvement due to the propensity for contiguous spread. Recently ROCM has shown an unprecedented resurgence during the current pandemic. Reports from different parts of the world indicated an increased risk and incidence of ROCM in patients who had required hospital admission and have recovered from moderate-to-severe COVID-19 disease. A majority of mucormycosis cases have been reported from India. The presence of diabetes mellitus (DM) and use of corticosteroids for COVID-19 pneumonia were found to be the key risk factors, resulting in higher mortality. Amidst the ongoing pandemic, with the third wave already having affected most of the world, it becomes imperative to adopt a risk-based approach toward COVID-19 patients predisposed to developing ROCM. This could be based on the most recently published literature and emerging data from centers across the world. The present review intended to elucidate the causes that brought about the current spike in ROCM and the importance of its early detection and management to reduce mortality, loss of eye, and the need for mutilating debridement.

show abstract

Section: Investigationsmentioning

confidence: 99%

Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review

Karkhur

Soni

Chauhan

et al. 2022

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…61 In a unique case, a 73-year-old male with diabetes mellitus was diagnosed with both AION and PION. 62 A brain MRI demonstrated abnormalities in the intraocular and intraorbital segments of the right optic nerve. The patient tested positive for COVID-19 and histopathology interestingly revealed rhino-orbital mucormycosis.…”

Section: Ischemic Optic Neuropathymentioning

confidence: 99%

Neuro-Ophthalmic Visual Impairment in the Setting of COVID-19

Dinkin

Sathi

2023

Semin Neurol

View full text Add to dashboard Cite

We set out to describe in detail the afferent neuro-ophthalmological complications that have been reported in association with coronavirus disease 2019 (COVID-19) infection. We describe and elaborate on mechanisms of disease, including para-infectious inflammation, hypercoagulability, endothelial damage, and direct neurotropic viral invasion. Despite global vaccination programs, new variants of COVID-19 continue to pose an international threat, and patients with rare neuro-ophthalmic complications are likely to continue to present for care.Afferent complications from COVID-19 include homonymous visual field loss, with or without higher cortical visual syndromes, resulting from stroke, intracerebral hemorrhage, or posterior reversible leukoencephalopathy. Optic neuritis has frequently been reported, sometimes along with acute disseminated encephalomyelopathy, often in association with either myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) or less commonly aquaporin-4 seropositivity or in newly diagnosed multiple sclerosis. Ischemic optic neuropathy has rarely been reported. Papilledema, resulting either from venous sinus thrombosis or idiopathic intracranial hypertension in the setting of COVID-19, has also been described.Observed afferent neuro-ophthalmic associations need to be confirmed though larger comparative studies. Meanwhile, the range of possible complications should be recognized by neurologists and ophthalmologists alike, to facilitate faster diagnosis and treatment of both COVID-19 and its neuro-ophthalmic manifestations.

show abstract

“…observed loss of vision or double vision in up to 49.3% of patients with ROM. Orbital cellulitis, orbital abscess, corneal edema, conjunctival chemosis, and fixed, dilated pupils have also been described [11,12] as well as orbital apex syndromes, endophthalmitis, retinoschisis, panophthalmitis, central retinal artery occlusion, cavernous sinus thrombosis, anterior, and posterior ischemic optic neuropathy, optic disc edema, and exudative retinal detachment [11,[13][14][15][16]. Occlusion of the superior ophthalmic vein or ophthalmic artery from vasculitis or thrombosis can lead to orbital and optic nerve infarction [17].…”

Section: Introductionmentioning

confidence: 99%

Rhino-orbital mucormycosis

Ryu

Laylani

Davila-Siliezar

et al. 2022

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

Purpose of reviewThe current article will update and review the clinical and radiological manifestations and management of rhino-orbital mucormycosis (ROM).Recent findingsThere has been an increase in cases of ROM worldwide, especially in India. Immunosuppression (especially diabetes mellitus) is a known predisposing risk factor for ROM. Delayed diagnosis and treatment of ROM can be vision or life-threatening. This article reviews the clinical and radiologic features, treatment, and prognosis of ROM with special emphasis on new and emerging therapies.SummaryROM is an angioinvasive fungal infection that affects the sinuses and orbits and may present to ophthalmologists. Clinicians should have a high index of suspicion for ROM, especially in patients with poorly controlled diabetes mellitus or other immunosuppression. Corticosteroid treatment (including the recent COVID-19 pandemic) may be a predisposing risk factor for ROM.

show abstract

Dual hit – Magnetic resonance imaging in concomitant anterior and posterior ischemic optic neuropathy in a case of rhino-orbital mucormycosis and COVID-19

Cited by 4 publications

References 2 publications

Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review

Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review

Neuro-Ophthalmic Visual Impairment in the Setting of COVID-19

Rhino-orbital mucormycosis

Contact Info

Product

Resources

About