2022
DOI: 10.1016/j.bbr.2022.113930
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Dual hit mouse model to examine the long-term effects of maternal immune activation and post-weaning social isolation on schizophrenia endophenotypes

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Cited by 13 publications
(14 citation statements)
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“…Differential expression analysis detected hundreds of dysregulated genes with approximately three times the number of DEGs in female (n = 1,215) compared to male (n = 400) hippocampal tissue. This is consistent with our behavioural data in these animals [ 10 ], which showed females to be more susceptible to SI-induced behavioural measures of anxiety and sociability. GO analysis identified that DEGs in both males and females were enriched in structural and functional synaptic ontologies with DEGs from females implicated in both overall presynapse and postsynapse ontologies, while DEGs from males were only implicated postsynapse ontologies.…”
Section: Discussionsupporting
confidence: 93%
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“…Differential expression analysis detected hundreds of dysregulated genes with approximately three times the number of DEGs in female (n = 1,215) compared to male (n = 400) hippocampal tissue. This is consistent with our behavioural data in these animals [ 10 ], which showed females to be more susceptible to SI-induced behavioural measures of anxiety and sociability. GO analysis identified that DEGs in both males and females were enriched in structural and functional synaptic ontologies with DEGs from females implicated in both overall presynapse and postsynapse ontologies, while DEGs from males were only implicated postsynapse ontologies.…”
Section: Discussionsupporting
confidence: 93%
“…This study builds on our previous behavioural work [ 10 ] using post-weaning SI mice and here investigates the molecular consequences of the environmental stressor on the mouse brain. The use of RNA-seq to investigate the transcriptomic changes in mouse hippocampus caused by SI presents a novel insight into the underlying molecular underpinnings of altered behaviour.…”
Section: Discussionmentioning
confidence: 99%
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