Abstract::
n-Butylidene phthalide (N-BP) is a natural derivative obtained from the chloroform extract
of Angelica Sinensis. In conventional medicine, it treats different ailments. Various pharmacological
properties are associated with it, including anticancer, anti-inflammatory, and neuroprotective
properties. Based on its reported pharmacokinetic profile, n-BP has low oral bioavailability and is
rapidly absorbed and eliminated from the body. The compound has diverse pharmacological effects
with lower stability, bioavailability, rapid absorption, and elimination. Furthermore, a targeted drug
delivery system using a nanocarrier can improve pharmacokinetic-molecular profiling, specificity,
efficacy, personal approach, and drug resistance. This review summarizes and emphasizes the pharmacokinetics,
and pharmacology of n-butylidene phthalide, and the molecular targeting approach to
treat cancer, inflammation, Parkinsonism, excitotoxicity, and Alzheimer’s.