2011
DOI: 10.1016/j.canlet.2011.05.010
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Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma

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Cited by 31 publications
(22 citation statements)
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“…In intestinal polyps, PGE 2 might accelerate adenomatous cell proliferation through the mechanism of activation of prostaglandin receptor EP2‐mediated cellular events. LTB 4 could stimulate the growth of intestinal polyps through phosphatidylinositol 3‐kinase/Akt signaling or by activation of a Ras‐MAPK signaling cascade 45. In this study, there were higher levels of PGE 2 and LTB 4 in the intestinal polyps of APC Min/+ mice in comparison with the normal intestinal mucosa of wild‐type mice.…”
Section: Discussionmentioning
confidence: 45%
“…In intestinal polyps, PGE 2 might accelerate adenomatous cell proliferation through the mechanism of activation of prostaglandin receptor EP2‐mediated cellular events. LTB 4 could stimulate the growth of intestinal polyps through phosphatidylinositol 3‐kinase/Akt signaling or by activation of a Ras‐MAPK signaling cascade 45. In this study, there were higher levels of PGE 2 and LTB 4 in the intestinal polyps of APC Min/+ mice in comparison with the normal intestinal mucosa of wild‐type mice.…”
Section: Discussionmentioning
confidence: 45%
“…Previous studies on the carcinogenesis of ESCC have mainly focused on genetic alterations including those in COX-2, BCL-2, p53, p16, cyclin D1, EGFR, VEGF, and E-cadherin [4], [18]. It is well known that carcinogenesis is a multistage process in which genetic and epigenetic changes lead to oncogene activation and tumor suppressor gene inactivation [19].…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have demonstrated the chemopreventive effects of ALOX5 and COX2 inhibitors, but most of these studies have been descriptive and lack a molecular underpinning 4046. A meta-analysis and multiple randomized controlled trials have shown that selective COX2 inhibitors can reduce the risk of colorectal adenomas and colorectal cancer 13,14,47,48.…”
Section: Discussionmentioning
confidence: 99%