Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products

Chandrasekaran, C.V.; Deepak, H.B.; Thiyagarajan, P.; Kathiresan, Sekar; Sangli, Gopal Krishna; Mundkinajeddu, Deepak; Agarwal, Amit

doi:10.1016/j.phymed.2010.08.001

Cited by 89 publications

(49 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such kind of positive feedback loop is thought to potentially affect immune or inflammatory responses. In this view, based on the previous (Chandrasekaran et al 2010b) and present findings we elucidate that the inhibitory response by G. glabra extract towards inflammatory and pro-inflammatory mediators is correlated. The inhibitory activity of the G. glabra extract on pro-inflammatory cytokines could be due to inhibition in PGE 2 production and vice versa.…”

Section: Resultssupporting

confidence: 63%

“…51) has been deposited in our herbarium. Preparation of the extract and isolation of the phytoconstituents was performed as described in our previous publication (Chandrasekaran et al 2010b). Briefly, the dried roots were extracted thrice using acetone in 1:4 proportions at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…In our recent publication we demonstrated the dual inhibitory (COX and LOX products) property of de-glycyrrhizinated extract of G. glabra root. We had demonstrated that inhibitory property of the G. glabra extract towards PGE 2 , TXB 2 and LTB 4 production is attributable to its phytoconstituents (Chandrasekaran et al 2010b). In addition, in another study, we had shown the anti-ulcer activity of de-glycyrrhizinated extract of G. glabra root (Mukherjee et al 2010).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…5-LOX catalyzing AA pathway results in the generation of leukotrienes (LTs) which are also actively involved in inflammatory diseases [33]. Due to the importance of PLA 2 /AA pathway in the pathogenesis of inflammatory diseases, inhibition of this pathway could suppress the release of AA pathway-generated lipid mediators and exhibit anti-inflammation activity [34,35].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

Xie

et al. 2015

Inflammation

View full text Add to dashboard Cite

Glycyrrhiza glabra (licorice) has been known to possess various pharmacological properties including anti-inflammatory, antioxidants, antiviral, and hepatoprotective activities. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-α glycyrrhizic acid stereoisomer, is clinically used for the treatment of inflammatory liver diseases. However, the mechanism by which MgIG exerts its anti-inflammatory effects remains unknown. In the present study, we investigated the inhibitory potential of MgIG in phospholipase A2 (PLA2)/arachidonic acid (AA) pathway and release of the pathway-generated inflammatory lipid mediators in RAW264.7 macrophages. Results revealed that MgIG suppressed LPS-induced activation of PLA2 and production of AA metabolites such as prostaglandin E2 (PGE2), prostacyclin (PGI2), thromboxane 2 (TXB2), and leukotrienes (LTB4) in macrophages. Furthermore, LPS-induced AA-metabolizing enzymes including COX-2, COX-1, 5-LOX, TXB synthase, and PGI2 synthase were significantly inhibited by MgIG. Taken together, our data suggest that modulation of cyclooxygenase (COXs) and 5-lipoxygenase (LOX) pathways in AA metabolism could be a novel mechanism for the anti-inflammatory effects of MgIG.

show abstract

“…It may interact with chemotherapy drugs by causing CYP3A induction. [114][115][116][117][118][119][120][121][122][123][124][125][126] Astragalus (wild licorice)…”

mentioning

confidence: 99%

Herbal Administration and Interaction of Cancer Treatment

Arslan

Tural

Akar

2013

Journal of Palliative Medicine

View full text Add to dashboard Cite

The widespread impact of cancer worldwide and noncurative treatment methods despite all developments drive patients towards investigating and using nonconventional treatment methods. Herbs, which have an important role in complementary and alternative medicine practices, may cause unfavorable results when used especially with chemotherapeutics in cancer patients due to the substances they contain and due to the properties of some, which still cannot be clarified. Further overshadowing the success of the treatments, patients do not talk about these issues with their doctors and physicians are unable to comprehend these properties of herbs. In this compilation we aimed to clarify the concepts of complementary and alternative medicine, to gather the properties of important and frequently used herbs, and to increase the awareness of physicians on this subject.

show abstract

Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products

Cited by 89 publications

References 19 publications

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

Herbal Administration and Interaction of Cancer Treatment

Contact Info

Product

Resources

About