Dual-layered composite nanofiber membrane with Cu-BTC-modified electrospun nanofibers and biopolymeric nanofibers for the removal of uremic toxins and its application in hemodialysis

Li, Wenyan; Shen, Chao; Li, Yumei; Bai, Fu‐Quan; Teng, Yakun; Li, Xiang; Li, Lijuan

doi:10.1016/j.memsci.2021.119964

Cited by 37 publications

(15 citation statements)

References 64 publications

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“…Compared with the original PA6 membrane without a tree‐like structure, the removal rates of small molecule toxins and middle molecule toxins were increased by 9% and 13%, respectively, and the retention rate of beneficial proteins was also increased by 18%. The porous structure and high porosity of the electrospun nanofibrous membrane as well as the increase in hydrophilicity facilitated diffusion and convection so that the middle molecule toxins were more easily carried by water through the membrane and removed 42 . The introduction of a tree‐like structure could limit the pore size and increase the contact area, thereby enhancing the interception of beneficial proteins and finally achieving effective improvement of beneficial protein retention 8,58 .…”

Section: Resultsmentioning

confidence: 99%

“…Electrospinning technology has great application value because of its large specific surface area, high porosity and easy modification of nanofibers. [38][39][40][41] Li et al 42 prepared a dual-layer composite hemodialysis membrane with both adsorption and dialysis capabilities by using electrospinning technology. The retention rate of bovine serum albumin (BSA) was 83.9%, and the clearance rates of creatinine and urea were 82.3% and 92.8%, respectively, showing good application potential.…”

Section: Introductionmentioning

confidence: 99%

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Tree‐like PA6/PVP/CS hemodialysis membrane to improve the contradiction between medium molecular toxins and proteins

Wang

Shao

et al. 2023

J of Applied Polymer Sci

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The contradiction between sufficient removal of middle molecular toxins and the retention of beneficial proteins is a great challenge for hemodialysis. The tree‐like structure was introduced to prepare a tree‐like PA6/PVP/CS nanofibrous membrane, which has good performance in the effective removal of middle molecular toxins and retention of beneficial proteins. The removal rates of urea and lysozyme were 75.4% and 46.3%, respectively, and the retention rate of bovine serum albumin (BSA) was 90.3%, which were 9%, 13%, and 18% higher than that of the membrane without tree‐like structure. In addition, to explore the possibility of further optimization of the tree‐like hemodialysis membrane, AC was added to prepare a tree‐like PA6/PVP/CS@AC nanofibrous membrane, which the urea removal rate was increased to 83.9%. The introduction of a tree‐like structure provides an effective way to solve the problem of protein loss and has great application potential in hemodialysis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tree‐like PA6/PVP/CS hemodialysis membrane to improve the contradiction between medium molecular toxins and proteins

Wang

Shao

et al. 2023

J of Applied Polymer Sci

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“…As a result, electrospun nanofiber membranes (ENMs) with random interconnected pores can be formed from overlapping fibers [ 31 , 32 , 33 ], which provide interconnected structures with high porosities that allow liquids to pass through multiple channels [ 34 , 35 ]. In addition, ENMs tend to exhibit a superior fouling resistance to traditional membranes, thereby mitigating the blockage of a single membrane pore and resulting in more promising filtration applications [ 24 , 36 , 37 ]. For example, a polyvinylidene fluoride (PVDF) ENM with pore sizes <200 nm was used to fabricate the bases of thin-film composite membranes, giving a high flux of 993 L/(m 2 ·h), which is three times that of the conventional casting membrane [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the excellent separation performances of ENMs are of particular interest in the medical field [ 42 ]. For example, a dual-layer nanofiber membrane composed of a polydopamine/polyacrylonitrile layer and a chitosan/sericin layer achieved creatinine and urea clearance rates of 82.3 and 92.8%, respectively, while retaining 83.9% of bovine serum albumin [ 37 ]. Moreover, a polymeric hemodialysis membrane composed of an electrospun polyacrylonitrile nanofibrous support layer achieved a 98.4% retention of bovine serum albumin after 4 h [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Recovery of Extracellular Polymeric Substances from Excess Sludge Using High-Flux Electrospun Nanofiber Membranes

et al. 2023

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The recycling of extracellular polymeric substances (EPSs) from excess sludge in wastewater treatment plants has received increasing attention in recent years. Although membrane separation has great potential for use in EPS concentration and recovery, conventional membranes tend to exhibit low water flux and high energy consumption. Herein, electrospun nanofiber membranes (ENMs) were fabricated using polyvinylidene fluoride (PVDF) and used for the recovery of EPSs extracted from the excess sludge using the cation exchange resin (CER) method. The fabricated ENM containing 14 wt.% PVDF showed excellent properties, with a high average water flux (376.8 L/(m2·h)) and an excellent EPS recovery rate (94.1%) in the dead-end filtration of a 1.0 g/L EPS solution at 20 kPa. The ENMs displayed excellent mechanical strength, antifouling properties, and high reusability after five recycles. The filtration pressure had a negligible effect on the average EPS recovery rate and water flux. The novel dead-end filtration with an EPS filter cake on the ENM surface was effective in removing heavy-metal ions, with the removal rates of Pb2+, Cu2+, and Cr6+ being 89.5%, 73.5%, and 74.6%, respectively. These results indicate the potential of nanofiber membranes for use in effective concentration and recycling of EPSs via membrane separation.

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“…Electrospinning, as an efficient and versatile technology to produce micro-and nanoscale fibers of natural and synthetic polymers with diameters ranging from 2 nm to several microns, has attracted worldwide attention. [1] The electrospinning process integrates the advantages of simple fabrication setup, low cost of DOI: 10.1002/marc.202200456 spinning, wide variety of spinnable materials, and controllable process. Electrospun fibers (EFs) belong to 1D linear materials, which can be transformed into 2D membrane materials as well as 3D bulk materials.…”

Section: Introductionmentioning

confidence: 99%

A Review: Current Status and Emerging Developments on Natural Polymer‐Based Electrospun Fibers

Han

Wang

et al. 2022

Macromol. Rapid Commun.

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In recent years, natural polymer‐based electrospun fibers (EFs) with huge specific surface area, good biocompatibility, and biological activity obtained from electrospinning process exhibit tremendous vitality in the field of biomedical areas. Herein, the parameters of electrospinning from two perspectives, polymer solution such as solvent, polymeric relative molecular mass, concentration, viscosity, and conductivity of the solution, and electrospinning process such as spinning voltage, spinning flow rate, needle tip to collector distance, temperature, and humidity are first detailed. Next, the raw materials consisting of polysaccharides such as cellulose, hyaluronic acid, alginate, and chitosan as well as proteins such as collagen, gelatin, silk fibroin, and keratin are summarized. The preparation method and related characteristics of EFs with multistage structures such as porous, core–shell, Janus, bamboo‐like and other structures are introduced. The biomedical applications of these natural polymer‐based EFs mainly including tissue engineering, drug sustained release, wound dressings, and biomedical sensors are systematically recapitulated. Finally, the outlook on natural EFs is further proposed.

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Dual-layered composite nanofiber membrane with Cu-BTC-modified electrospun nanofibers and biopolymeric nanofibers for the removal of uremic toxins and its application in hemodialysis

Cited by 37 publications

References 64 publications

Tree‐like PA6/PVP/CS hemodialysis membrane to improve the contradiction between medium molecular toxins and proteins

Tree‐like PA6/PVP/CS hemodialysis membrane to improve the contradiction between medium molecular toxins and proteins

Recovery of Extracellular Polymeric Substances from Excess Sludge Using High-Flux Electrospun Nanofiber Membranes

A Review: Current Status and Emerging Developments on Natural Polymer‐Based Electrospun Fibers

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