Dual malignancy in a thyroid; papillary thyroid carcinoma and small lymphocytic lymphoma; a report of a case with a cyto‐histologic correlation

Ahmed, Omar; Salih, Ziyan

doi:10.1002/dc.23748

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…A summary of these reports is shown in Table 3. [15][16][17][18][19][20][21][22][23][24][25] Consistent with previous findings, all the 8 patients in our study were female and had papillary thyroid cancers. The phenomenon that these DPM occurs more frequently in women may be related to the fact that thyroid cancer is more common in women than man.…”

Section: Discussionsupporting

confidence: 91%

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Synchronous double primary lymphoma and thyroid cancer

Zhu²,

Xiao³

et al. 2021

Medicine

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Synchronous double primary malignancies of lymphoma and thyroid cancer are rare. In this retrospective study, we investigated the pathology, clinical characteristics, and treatment outcomes of patients with synchronous lymphoma and thyroid cancer. Of the 1156 newly diagnosed lymphoma patients treated in our hospital between January 1, 2016 and February 1, 2021, 8 cases had lymphoma complicated with thyroid cancer. The clinical data and treatment strategies of 8 cases with synchronous lymphoma and thyroid cancer were retrospectively analyzed. The median age of patients was 56 (25–64) years. All the 8 patients were female and papillary thyroid cancer. Only 1 patient had peripheral T-cell lymphoma, and the other 7 were B-cell lymphoma. Seven of 8 patients had normal free triiodothyronine and free thyroxine at the time of diagnosis. Seven thyroid cancer patients received total thyroidectomy and levothyroxine and the remaining 1 patient has a plan for surgery. At the last follow-up, 7 patients with B-cell lymphoma are alive; the patient with peripheral T-cell lymphoma complicated with thyroid cancer died due to lymphoma progression. Synchronous lymphoma and thyroid cancer are more predominant in women. Histologically, B-cell lymphomas and papillary thyroid cancer subtypes are more common. Attention should be paid to the presence of thyroid nodules in the diagnosis of lymphoma. Biopsy or ultrasound-guided fine needle aspiration of the suspicious thyroid nodule should be performed to exclude thyroid malignancy.

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Section: Discussionsupporting

confidence: 91%

“…To our knowledge, rarely has any study to date investigated the association between synchronous thyroid cancer and lymphoma, most of previous reports are case reports. A summary of these reports is shown in Table 3 [15–25] . Consistent with previous findings, all the 8 patients in our study were female and had papillary thyroid cancers.…”

Section: Discussionsupporting

confidence: 88%

Synchronous double primary lymphoma and thyroid cancer

Zhu²,

Xiao³

et al. 2021

Medicine

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“…It should not be forgotten that thyroid lymphomas may be accompanied by other primary neoplasms of the thyroid (papillary, follicular, anaplastic). For this reason, in addition to histopathological analysis, immunohistochemical staining with monoclonal antibodies should also be performed (7). One of our cases displayed a coexistence with papillary thyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Approach to primary thyroid lymphoma: case series

Acar

Avcı

et al. 2019

Turk J Surg

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Primary thyroid lymphomas are rare thyroid neoplasms. Mucosa Associated Lymphoid tissue (MALT) lymphoma and diffuse large B-cell Non-Hodgkin lymphoma are the most common types. It is more common in the elderly, and especially in women. Patients usually present with a rapidly growing mass in the neck. This article aimed to present the epidemiological features, treatment and prognostic factors of thyroid lymphomas by retrospectively reviewing 4 patients with thyroid lymphoma. Four patients were treated for primary thyroid lymphoma, two of whom were women and two were men, with a mean age of 63.7 (51-74) years. Common complaint of those patients was the sudden swelling of the neck. Two patients were diagnosed with fine needle aspiration biopsy (FNAB) and the other two patients were diagnosed with surgical excision. Chemotherapy and radiotherapy were applied to all four patients. While one patient died in the second year of follow-up, the other three patients are still being followed. Primary thyroid lymphomas are not aggressive tumors, and the most effective treatment is radiotherapy.

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“…By ICC, the cells express CD19, CD20, CD23, and CD5, and they are negative for CD3 and CD10. The presence of 17p13 deletion (TP53 gene) was detected in a case [34, 35].…”

Section: Lymphomamentioning

confidence: 99%

Small-Cell Malignancies of Thyroid: Challenge Solved?

Canberk¹,

Thodou²,

Bongiovanni³

2022

Acta Cytologica

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“Small-cell malignancies of thyroid” is an unsolved dilemma. This term represents an umbrella terminology in thyroid, encompassing for a small group of tumors in which some of them are well-recognized tumors like medullary thyroid carcinoma, poorly differentiated thyroid carcinoma, and primary thyroid lymphomas and teratoma, whereas the remaining are less known as primary neuroendocrine carcinoma of thyroid, primary extraskeletal Ewing family tumors, and adamantinoma-like Ewing sarcoma. When the issue comes to evaluate a cytological sample predominantly composed of small-cell morphology, metastatic small-cell carcinomas to thyroid also should be excluded. In this review, our group focused on the main cytomorphological and clinical clues of each entity that help to set up a correct differential diagnosis. The literature discussions were also included for the entities that are not yet recognized by the mother publication WHO. A key point of the issue’s simple algorithm based on FNAC with small-cell morphology of thyroid was suggested by the authors.

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Dual malignancy in a thyroid; papillary thyroid carcinoma and small lymphocytic lymphoma; a report of a case with a cyto‐histologic correlation

Cited by 7 publications

References 29 publications

Synchronous double primary lymphoma and thyroid cancer

Synchronous double primary lymphoma and thyroid cancer

Approach to primary thyroid lymphoma: case series

Small-Cell Malignancies of Thyroid: Challenge Solved?

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