2015
DOI: 10.1364/boe.6.001665
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Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques

Abstract: New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques that combines optical coherence tomography (OCT) and two-photon luminescence (TPL) imaging. Experimental results from ex vi… Show more

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Cited by 6 publications
(3 citation statements)
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References 61 publications
(71 reference statements)
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“…why some rupture and others thicken, and how pharmaceutical agents interact with TCFAs) an in vivo imaging system is needed that can improve the limited PPV identified in the current study. One possibility is to couple a second imaging modality with IVOCT—for instance: intravascular ultrasound 10, 27 , fluorescence lifetime imaging microscopy 28 , near infrared fluorescence 29 , spectral OCT 30 or two-photon luminescence (TPL) 31, 32 . TPL is an interesting candidate having the ability to image the actual molecular composition of plaque without the use of exogenous contrast agents.…”
Section: Discussionmentioning
confidence: 99%
“…why some rupture and others thicken, and how pharmaceutical agents interact with TCFAs) an in vivo imaging system is needed that can improve the limited PPV identified in the current study. One possibility is to couple a second imaging modality with IVOCT—for instance: intravascular ultrasound 10, 27 , fluorescence lifetime imaging microscopy 28 , near infrared fluorescence 29 , spectral OCT 30 or two-photon luminescence (TPL) 31, 32 . TPL is an interesting candidate having the ability to image the actual molecular composition of plaque without the use of exogenous contrast agents.…”
Section: Discussionmentioning
confidence: 99%
“…); and Cardiology: identifying and characterizing atherosclerotic plaques (Wang et al. ). These developments suggest that OCT might be of significant benefit to the management of the superficial layers of the ocular adnexae.…”
Section: Introductionmentioning
confidence: 99%
“…Combination imaging strategies such as PET-CT or SPECT-CT scanners can provide complementary and supplemental information pertaining to morphology and function that is relevant in a clinical context, making them superior to unimodal imaging in most contexts ( 117 ). In recent years, researchers have explored the utility of SPECT-CT, IVUS-intravascular photoacoustic (IVPA), IVUS-fluorescence lifetime imaging (FLIM), IVUS-intravascular (IVOCT), and IVOCT-NIRF combination approaches to the high-specificity detection of plaque structure and composition ( 118 ). Moreover, the development of thrombosis-specific molecular imaging agents to detect and monitor thrombogenesis and fibrinolysis in vivo have positive outcomes to improve the diagnosis, risk stratification, and treatment of thrombosis syndromes.…”
Section: Molecular Imaging Of Thrombosismentioning
confidence: 99%