2023
DOI: 10.3390/bios13030317
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Dual-Mode Sensing Platform for Cancer Antigen 15-3 Determination Based on a Silica Nanochannel Array Using Electrochemiluminescence and Electrochemistry

Abstract: An electrochemiluminescence-electrochemistry (ECL-EC) dual-mode sensing platform based on a vertically-ordered mesoporous silica films (VMSF) modified electrode was designed here for the sensitive and selective determination of cancer antigen 15-3 (CA 15-3), a specific biomarker of breast cancer. VMSF was assembled through a rapid electrochemically assisted self-assembly (EASA) method and plays a crucial role in signal amplification via a strong electrostatic interaction with the positively charged bifunctiona… Show more

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Cited by 41 publications
(32 citation statements)
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“…[129,145,162,165,169-À 172,179,180,235-242] ECL can be also used as a readout signal for the biosensors, providing a high sensitive and selective method of detection of substrates in enzymatic electrochemical biosensors as well as immuno-and aptasensors (see examples in Tables 3&4). [126,127,151,161,222,[243][244][245][246][247] They are mostly based on the two commonly used luminophores luminol and Ru(bpy) 3 2 +…”
Section: Sensors Based On Electrochemiluminescence Detectionmentioning
confidence: 99%
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“…[129,145,162,165,169-À 172,179,180,235-242] ECL can be also used as a readout signal for the biosensors, providing a high sensitive and selective method of detection of substrates in enzymatic electrochemical biosensors as well as immuno-and aptasensors (see examples in Tables 3&4). [126,127,151,161,222,[243][244][245][246][247] They are mostly based on the two commonly used luminophores luminol and Ru(bpy) 3 2 +…”
Section: Sensors Based On Electrochemiluminescence Detectionmentioning
confidence: 99%
“…They will be noted as vertically‐oriented mesoporous silica film (VMSF) hereafter. Several kinds of composite films can be distinguished: (1) those made of the mesoporous silica film filled with the organic template used for its synthesis (mainly surfactants [25–27,33,137] but also coordination polymers [183] ), mainly deposited on flat electrode surfaces as indium‐tin oxide (ITO) [163,164,173,175,177,178] or electrodeposited as nanocomposite films around reduced graphene oxide; [125] (2) those made of surfactant‐extracted mesoporous silica electrodeposited as nanocomposite films around various kinds of nanocarbons (reduced graphene oxide, three‐dimensional graphene, carbon nanotubes or graphene‐carbon nanotube assemblies); [121,123–−125,128,130,138,140,146,149,153,155,156] (3) a wide range of chemically modified mesoporous silica films that can be basically divided further in two categories depending on whether they contain organo‐functional groups (either weakly immobilized [126,129,139,145,162,165,166,169,171,172,176,179,180] or strongly attached via covalent bonds [116,118–−120,122,126,127,131,133,134,136,137,143,147,150−152,157,160,161,174] ) or serve as hosts for nano‐objects (such as polymers [140,141,158] or nanoparticles [159,167,168,170,181,182] ); and (4) other composites made of ordered silica films combined with other nanomaterials (such as clays, [117,132,135] for instance). An illustrative summary of the various sensing applications of composite electrodes made of VMSF materials, respectively with filled pores, open pores and functionalized pores, is given in Figure 4.…”
Section: Electrochemical Sensors Designed From Composite Silica Filmsmentioning
confidence: 99%
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“…Recent studies have proven that silica nanochannel array film (SNA), also vertically-ordered silica nanochannels film (VMSF), is attractive as a matrix to enrich electrochemical or electrochemiluminescence probes (Liang et al, 2021;Ma et al, 2022a) SNA is a nanoscale ultrathin film (20-200 nm) with high pore density (~7.5 × 10 12 pores/cm 2 ), ultrasmall (2-3 nm) nanochannel array (Walcarius, 2021;Yan et al, 2021) These unique structures endow SNA modified electrodes with significant advantages in electrochemical sensing applications (Ma et al, 2022b;Huang et al, 2022;Zou et al, 2022) For instance, ultrasmall nanochannels have screening capabilities on molecular level. On the one hand, the large substances in complex matrices cannot enter the nanochannels, leading to high anti-fouling of the electrodes (Zhou et al, 2022a;Zhou et al, 2022b;Deng et al, 2023) On the other hand, the dissociation of silanol groups (Si-OH, pK a ~2) in SNA makes the surface of nanochannel negatively charged, which can enrich positively charged molecules through electrostatic interaction (Zheng et al, 2022c;Wang et al, 2022;Huang et al, 2023) The charge of SNA can also be reversed by introducing functional groups. Thus, functional nanostructures, e.g., electrostatic nanocage arrays, can be flexibly designed by growing multilayer of SNA (Gong et al, 2022b;Gong et al, 2022c) Secondly, SNA with confined probe can generate gating signal when biomacromolecules are detected.…”
Section: Introductionmentioning
confidence: 99%
“…Vertically ordered mesoporous silica films [also termed as silica nanochannel array (SNA)] are a kind of synthetic nanoporous membrane with selective permeability and controlled molecular transport, which enable the design of a vast variety of novel electrochemical/electrochemiluminescent sensors. Their unique characteristics with respect to the ultrasmall and uniform diameter of silica pores, ultrathin, high porosity, and insulated property especially offer a broad prospect for the direct analysis of complicated biological samples. Analytes with redox-active characteristic can be directly determined based on their electrochemical signals on the SNA-based sensors. , As for the tumor biomarkers without electroactive property, both recognition elements and probes are employed and the target-introduced large complex on the outer surface of SNA leads to the signal variation of free electrochemical/ECL probes in solution or electrochemical/ECL probes immobilized on the SNA-based sensors and further realizes their quantitative determination. In contrast, probes immobilized into the nanochannels of SNA offer advantages of easy detection operations, sparing chemical reagents, and low cost without the addition of exogeneous reagents. Su’s group has reported a nanocage consisting of SNA bilayers with different pore diameters for physical trapping ECL probe (tris­(4,7-diphenyl-1,10-phenanthroline)­ruthenium­(II) dichloride), allowing the determination of dopamine released from living PC cells based on the quenching effect .…”
Section: Introductionmentioning
confidence: 99%