Dual-network hydrogels based on dynamic imine and borate ester bonds with antibacterial and self-healing properties

Liu, Yalei; Chang, Junfang; Mao, Jie; Wang, Sui; Guo, Zhiyong; Hu, Yufang

doi:10.1016/j.colsurfb.2023.113528

Cited by 15 publications

(4 citation statements)

References 37 publications

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“…The peaks at 3300 and 2920 cm –1 are assigned to the O–H stretching vibration of α-CDs and −CH 2 – of PEG, indicating the existence of the pPRX hydrogel. With the addition of B(OH) 3 , in the spectra of pPRX 2 -AAM-B 3 hydrogel, the −NH 2 peak of AAM and the −OH peak of pPRX are diminished along with borate ester bonds formed. − The peak show at 1190 cm –1 attributing to the B–O–H stretching of B(OH) 3 and that at 1420 cm –1 to the B–O stretching . The characteristic peaks of borate ester bonds appear at 1340 cm –1 , which can be assigned to the asymmetric stretching relaxation of B–O–C.…”

Section: Results and Discussionmentioning

confidence: 99%

Facile Preparation of Tough, Puncture-Resistant Antibacterial Polyrotaxane Hydrogel

Zheng,

Jiang,

Tian

et al. 2024

ACS Appl. Mater. Interfaces

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Slide-ring hydrogels containing polyrotaxane structures have been widely developed, but current methods are more complex, in which modified cyclodextrins, capped polyrotaxanes, and multistep reactions are often needed. Here, a simple one-pot method dissolving the pseudopolyrotaxane (pPRX) in a mixture of acrylamide and boric acid to form a slide-ring hydrogel by UV light is used to construct a tough, puncture-resistant antibacterial polyrotaxane hydrogel. As a new dynamic ring cross-linking agent, boric acid effectively improves the mechanical properties of the hydrogel and involves the hydrogel with fracture toughness. The polyrotaxane hydrogel can withstand 1 MPa compression stress and maintain the morphology integrity, showing 197.5 mJ puncture energy under a sharp steel needle puncture. Meanwhile, its significant antibacterial properties endow the hydrogel with potential applications in the biomedical field.

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Section: Results and Discussionmentioning

confidence: 99%

Facile Preparation of Tough, Puncture-Resistant Antibacterial Polyrotaxane Hydrogel

Zheng,

Jiang,

Tian

et al. 2024

ACS Appl. Mater. Interfaces

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“…Due to the formation of hydrogen bonds, FT-IR spectra revealed a characteristic of the carbonyl stretching vibration (ν(C=O)) due to hydrogen bonding at 1650-1750 cm 1 [32], resulting in both broadening and a slight decrease in frequency compared to the peak observed in the absence of hydrogen bonding at 3400-3300 cm 1 [33]. It was indicated that the shifting of ν(C=O) suggests an enhanced hydrogen bonding interaction between the OH groups of PVA and the carbonyl groups (C=O) of the free acid and ester groups in the CMC/PVA hydrogel [21,34,35]. Consequently, the ν(C=O) peak in the FT-IR spectra indicates the presence of hydrogen bonding in the CMC/PVA hydrogel, showing the strong bonding vibration signals and strength of hydrogen bonds within the molecule.…”

Section: Hydrogel Functional Structure Analysismentioning

confidence: 99%

Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing

Pratinthong,

Punyodom,

Jantrawut

et al. 2024

Polymers

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Anti-inflammatory wound healing involves targeted drug delivery to the wound site using hydrogel materials to prolong drug effectiveness. In this work, hydrogel films were fabricated using carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked with citric acid (CA) and glutaraldehyde (GA) at different concentrations. The crosslinker densities were optimized with various CA (2–10% w/v) and GA (1–5% v/v) concentrations. The optimized crosslink densities in the hydrogel exhibited additional functional group peaks in the FT-IR spectra at 1740 cm−1 for the C=O stretching of the ester linkage in CA and at 1060 cm−1 for the C-O-C stretching of the ether group in GA. Significantly, the internal porous structures of hydrogel composite films improved density, swelling capacities, solubility percentage reduction, and decreased water retention capacities with optimized crosslinker densities. Therefore, these hydrogel composite films were utilized as drug carriers for controlled drug release within 24 h during medical treatment. Moreover, the hydrogel films demonstrated increased triamcinolone acetonide (TAA) absorption with higher crosslinker density, resulting in delayed drug release and improved TAA efficiency in anti-inflammatory activity. As a result, the modified hydrogel showed the capability of being an alternative material with enhanced anti-inflammatory efficiency with hydrogel films.

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“…These multi-responsive hydrogels offer a feasible solution for the precise control of the network of the hydrogels and their mechanical properties. Wang et al introduced both dynamic imine bonds and boronic ester bonds to prepare a self-healing PVA/PEI/DCMC/CMCS hydrogel with antibacterial properties [27]. The aldehyde groups in dialdehyde carboxymethyl cellulose (DCMC) were reacted with the amine groups in polyethyleneimine (PEI) and carboxymethyl chitosan (CMCS) to form dynamic imine bonds.…”

Section: Chemical Design Of Dynamic Hydrogelsmentioning

confidence: 99%

Dynamic Hydrogels against Infections: From Design to Applications

Zhang,

Zhu

2024

Gels

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Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to be an effective localized drug delivery approach to treating infections without generating significant systemic adverse effects. The recent emerging dynamic hydrogels further show power as injectable formulations, giving new tools for clinical treatments. In this review, we delve into the potential applications of dynamic hydrogels in antibacterial and antiviral treatments and elaborate on their molecular designs and practical implementations. By outlining the chemical designs underlying these hydrogels, we discuss how the choice of dynamic chemical bonds affects their stimulus responsiveness, self-healing capabilities, and mechanical properties. Afterwards, we focus on how to endow dynamic hydrogels with anti-infection properties. By comparing different drug-loading methods, we highlight the advantages of dynamic chemical bonds in achieving sustained and controlled drug release. Moreover, we also include the design principles and uses of hydrogels that possess inherent anti-infective properties. Furthermore, we explore the design principles and applications of hydrogels with inherent anti-infective properties. Finally, we briefly summarize the current challenges faced by dynamic hydrogels and present a forward-looking vision for their future development. Through this review, we expect to draw more attention to these therapeutic strategies among scientists working with chemistry, materials, as well as pharmaceutics.

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Dual-network hydrogels based on dynamic imine and borate ester bonds with antibacterial and self-healing properties

Cited by 15 publications

References 37 publications

Facile Preparation of Tough, Puncture-Resistant Antibacterial Polyrotaxane Hydrogel

Facile Preparation of Tough, Puncture-Resistant Antibacterial Polyrotaxane Hydrogel

Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing

Dynamic Hydrogels against Infections: From Design to Applications

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