Dual pH-responsive charge-reversal and photo-crosslinkable polymer nanoparticles for controlled drug release

Wang, Meijie; He, Kaiwei; Li, Jilu; Shen, Tong; Li, Yang; Xu, Yiting; Yuan, Conghui; Dai, Lizong

doi:10.1080/09205063.2020.1725279

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…Under the p K a , PDMAEMA is hydrophilic as its amine groups are protonated. Above its p K a , PDMAEMA is hydrophobic as its amine groups are deprotonated, so PDMAEMA-based copolymers have been developed to achieve reduced toxicity . The carboxyl group on PMAA can react with the amino group on doxorubicin to form an amide bond.…”

Section: Resultsmentioning

confidence: 99%

Redox-Sensitive Hyaluronic Acid Polymer Prodrug Nanoparticles for Enhancing Intracellular Drug Self-Delivery and Targeted Cancer Therapy

Lü

Fan

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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Currently, available nanoscale anticancer drug delivery systems have low targeting and release efficiency, limiting their therapeutic effects. Thus, tumortargeting nanocarriers for self-assembly of amphiphilic polymer−drug conjugates are urgently needed to improve drug targeting and treatment efficacy. Here, we report the construction of a stable, reduction-sensitive prodrug conjugate based on hyaluronic acid-grafted pH-sensitive doxorubicin (DOX). The amphiphilic prodrug copolymer self-assembled into spherical nanoparticles in aqueous solution and exhibited an average diameter of 150 nm. Prodrug micelles were stable in a normal physiological environment and achieve selective and rapid release under acidic pH and/or high reduction conditions. Cell Counting Kit-8, flow cytometry, and live cell imaging assays showed that the prodrug had high targeting and antitumor activity against CD44 receptors. Moreover, in vivo pharmacokinetics and biodistribution studies showed that the prodrug had a longer circulation time in BALB/c mice and higher accumulation in 4T1 tumors. Interestingly, the prodrug could effectively treat tumors with few side effects. These results showed that the DOX prodrug micelles developed in this study may have great potential in targeted therapy.

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Section: Resultsmentioning

confidence: 99%

Redox-Sensitive Hyaluronic Acid Polymer Prodrug Nanoparticles for Enhancing Intracellular Drug Self-Delivery and Targeted Cancer Therapy

Lü

Fan

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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“…Results exhibited a charge reversion from −27.88 to +19.44 mV in strong acidic environments. [ 52 ] In other NPs, PDEAEMA was grafted on the outer surface and subsequently functionalized with cysteine, yielding PDEAEMA‐Cys‐NPs, or with cysteine and poly(oligo(ethylene glycol) methyl ether methacrylate), yielding PDEAEMA‐Cys‐POEGMEMA‐NPs. The PDEAEMA‐NPs exhibited a positive surface charge under pH conditions lower than 7, with an average value of +25 mV.…”

Section: Stimuli Triggering Charge Reversal Of Nanoparticlesmentioning

confidence: 99%

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Veider,

Sanchez Armengol,

Bernkop‐Schnürch

2023

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The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address the polycation dilemma. Converting their surface charge from negative/neutral to positive at the target site, they can substantially improve delivery of drugs and diagnostic agents. By specific stimuli like a shift in pH and redox potential, enzymes, or exogenous stimuli such as light or heat, charge reversal of NP surface can be achieved at the target site. The activated positive surface charge enhances the adhesion of NPs to target cells and facilitates cellular uptake, endosomal escape, and mitochondrial targeting. Because of these properties, the efficacy of incorporated drugs as well as the sensitivity of diagnostic agents can be essentially enhanced. Furthermore, charge‐reversible NPs are shown to overcome the biofilm formed by pathogenic bacteria and to shuttle antibiotics directly to the cell membrane of these microorganisms. In this review, the up‐to‐date design of charge‐reversible NPs and their emerging applications in drug delivery and diagnosis are highlighted.

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“…[ 38 ] Multiple pH‐responsive blocks give further tunability in the form of controlling charge distribution and allowing charge reversal. [ 39–42 ]…”

Section: Introductionmentioning

confidence: 99%

“…[38] Multiple pH-responsive blocks give further tunability in the form of controlling charge distribution and allowing charge reversal. [39][40][41][42] Including charged segments in multiblock polymers combines all these possibilities in a single system, which, however, accordingly becomes rather complex. While the choice of the block sequence and the volume fractions provides the basis for structural control, the electrostatic interactions may ensure strong segregation and further tuning of the nanostructure.…”

Section: Introductionmentioning

confidence: 99%

Highly Tunable Nanostructures in a Doubly pH‐Responsive Pentablock Terpolymer in Solution and in Thin Films

Jung

Schart

Bührend

et al. 2021

Adv Funct Materials

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Multiblock copolymers with charged blocks are complex systems that show great potential for enhancing the structural control of block copolymers. A pentablock terpolymer PMMA‐b‐PDMAEMA‐b‐P2VP‐b‐PDMAEMA‐b‐PMMA is investigated. It contains two types of midblocks, which are weak cationic polyelectrolytes, namely poly(2‐(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(2‐vinylpyridine) (P2VP). Furthermore, these are end‐capped with short hydrophobic poly(methyl methacrylate) (PMMA) blocks in dilute aqueous solution and thin films. The self‐assembly behavior depends on the degrees of ionization α of the P2VP and PDMAEMA blocks, which are altered in a wide range by varying the pH value. High degrees of ionization of both blocks prevent structure formation, whereas microphase‐separated nanostructures form for a partially charged and uncharged state. While in solutions, the nanostructure formation is governed by the dependence of the P2VP block solubility of the and the flexibility of the PDMAEMA blocks on α, in thin films, the dependence of the segregation strength on α is key. Furthermore, the solution state plays a crucial role in the film formation during spin‐coating. Overall, both the mixing behavior of the 3 types of blocks and the block sequence, governing the bridging behavior, result in strong variations of the nanostructures and their repeat distances.

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Dual pH-responsive charge-reversal and photo-crosslinkable polymer nanoparticles for controlled drug release

Cited by 10 publications

References 51 publications

Redox-Sensitive Hyaluronic Acid Polymer Prodrug Nanoparticles for Enhancing Intracellular Drug Self-Delivery and Targeted Cancer Therapy

Redox-Sensitive Hyaluronic Acid Polymer Prodrug Nanoparticles for Enhancing Intracellular Drug Self-Delivery and Targeted Cancer Therapy

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Highly Tunable Nanostructures in a Doubly pH‐Responsive Pentablock Terpolymer in Solution and in Thin Films

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