Dual-Porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Nonhuman Enzymes

Ortac, Inanc; Simberg, Dmitri; Yeh, Ya san; Yang, Jian; Messmer, Bradley T.; Trogler, William C.; Tsien, Roger Y.; Esener, Sadik C.

doi:10.1021/nl404360k

Cited by 67 publications

(77 citation statements)

References 45 publications

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“…Nanocarriers help prevent drug degradation by evading the reticuloendothelial system (RES) and increase the bioavailability of the therapeutic agents at the target site [150][151][152]. In turn, adverse systemic side effects often decrease, while efficacy of the drug is enhanced.…”

Section: Nanotechnology For Combination Therapymentioning

confidence: 99%

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp

Shim

Heo

et al. 2016

Advanced Drug Delivery Reviews

437

258

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a b s t r a c t a r t i c l e i n f oThe dynamic and versatile nature of diseases such as cancer has been a pivotal challenge for developing efficient and safe therapies. Cancer treatments using a single therapeutic agent often result in limited clinical outcomes due to tumor heterogeneity and drug resistance. Combination therapies using multiple therapeutic modalities can synergistically elevate anti-cancer activity while lowering doses of each agent, hence, reducing side effects. Co-administration of multiple therapeutic agents requires a delivery platform that can normalize pharmacokinetics and pharmacodynamics of the agents, prolong circulation, selectively accumulate, specifically bind to the target, and enable controlled release in target site. Nanomaterials, such as polymeric nanoparticles, gold nanoparticles/cages/shells, and carbon nanomaterials, have the desired properties, and they can mediate therapeutic effects different from those generated by small molecule drugs (e.g., gene therapy, photothermal therapy, photodynamic therapy, and radiotherapy). This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

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Section: Nanotechnology For Combination Therapymentioning

confidence: 99%

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp

Shim

Heo

et al. 2016

Advanced Drug Delivery Reviews

437

258

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“…Various templates have been used for the control of the pore size, such as micelles of block copolymers, polymer nanoparticles, and emulsions. 43,86,151,167,267,305345 Here, we will introduce major examples of pore size control using these templates.…”

Section: Soft Template;mentioning

confidence: 99%

Colloidal Mesoporous Silica Nanoparticles

Yamamoto

Kuroda

2016

Bulletin of the Chemical Society of Japan

198

100

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IMMA. His current research interests include mesostructured materials, and several fields of inorganic materials chemistry. Some examples are intercalation chemistry, silicate chemistry, inorganic polymers, sol-gel chemistry, inorganic-organic hybrids, and self-organized materials. AbstractMesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and applications which include biomedical, catalytic, and optical materials. The following two points have been emphasized. The first point is that this review covers the widest range of introduction and discussion of the preparation and applications of both colloidal and noncolloidal MSNs. The second point is that this account contains a discussion from the viewpoints of both inorganic and colloid chemistries. After the introduction of the historical background of preparation of MSNs, preparative methods of colloidal MSNs and the major factors for the preparation of nanosized and colloidal MSNs are discussed. The methods to control the size, composition, morphology, and pore size of MSNs are also presented. Appropriate methods to obtain MSNs with high colloidal dispersibility are also discussed. Applications of colloidal MSNs are introduced with an emphasis on the colloidal stability. Issues to be addressed for further developments of colloidal MSNs are finally described.

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“…One example of HMSN synthesis using polystyrene nanoparticles as templates for pore and hollow structure formation. [467].…”

Section: Carbon Frameworkmentioning

confidence: 99%

“…The empty voids of HMSNs also offer flexibility in encapsulating enzymes to interact with diffusing species, thus forming biological nanoreactors. Ortac et al [467] demonstrated a polystyrene template approach to produce highly uniform HMSNs that were capable of being loaded with various enzymes and then protected by additional, controlled silica formation around the porous shell. The resulting nanoparticles boast a long circulation time due to the preserved enzymatic activity and capability to still interact with its target.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Literature supporting both highly biocompatible [507][508][509] and toxic sides of the argument [510] has led toward recent attention toward to HMSNs and particularly, their functionalization. As the frequently used polystyrene core template is highly uniform and cleanly removed from the final product, the resulting MSN shells are highly monodisperse and homogeneous [467], which improves their biocompatibility. The hollow aspect of HMSNs has significant advantages over traditional MSNs, in addition to less silica material being present, which is the major concern about MSN toxicity.…”

Section: Trends and Conclusionmentioning

confidence: 99%

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Template-based syntheses for shape controlled nanostructures

Pérez-Page

et al. 2016

Advances in Colloid and Interface Science

136

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A variety of nanostructured materials are produced through template-based synthesis methods, including zerodimensional, one-dimensional, and two-dimensional structures. These span different forms such as nanoparticles, nanowires, nanotubes, nanoflakes, and nanosheets. Many physical characteristics of these materials such as the shape and size can be finely controlled through template selection and as a result, their properties as well. Reviewed here are several examples of these nanomaterials, with emphasis specifically on the templates and synthesis routes used to produce the final nanostructures. In the first section, the templates have been discussed while in the second section, their corresponding synthesis methods have been briefly reviewed, and lastly in the third section, applications of the materials themselves are highlighted. Some examples of the templates frequently encountered are organic structure directing agents, surfactants, polymers, carbon frameworks, colloidal sol-gels, inorganic frameworks, and nanoporous membranes. Synthesis methods that adopt these templates include emulsion-based routes and template-filling approaches, such as self-assembly, electrodeposition, electroless deposition, vapor deposition, and other methods including layer-by-layer and lithography. Templatebased synthesized nanomaterials are frequently encountered in select fields such as solar energy, thermoelectric materials, catalysis, biomedical applications, and magnetowetting of surfaces.

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Dual-Porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Nonhuman Enzymes

Cited by 67 publications

References 45 publications

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Colloidal Mesoporous Silica Nanoparticles

Template-based syntheses for shape controlled nanostructures

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