Dual-purpose vardenafil hydrochloride/dapoxetine hydrochloride orodispersible tablets: in vitro formulation/evaluation, stability study and in vivo comparative pharmacokinetic study in healthy human subjects

Abstract

Erectile dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in vitro disintegration time, wetting time, and the dissolution study. Gelatin as a matrix former with N-methylpyrrolidone as a solubilizer in VH/DH ODTs improved the dissolution rate and extent of release of VH and DH with 100% of drug being dissolved after 15 min. In vivo study results from six healthy male volunteers showed shorter T of VH from VH/DH ODT of 0.583 ± 0.129 h and shorter T of DH from VH/DH ODT of 0.625 ± 0.137 h and showed AUC of VH from VH/DH ODT of 39.234 ± 10.932 ng/mlh and AUC of DH from VH/DH ODT of 531.681 ± 129.544 ng/mlh, with relative bioavailability values of 100.9 and 85%, respectively, compared to (Levitra) and (Priligy).

Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability

“…Vardenafil hydrochloride (VAR) is a selective phosphodiesterase V (PDE-5) inhibitor that exhibits vasodilatory activity [ 1 , 2 ]. By inhibiting the degradation of cyclic guanosine monophosphate (cGMP), it causes prolonged relaxation of a muscle, dilation of vessels, and increased blood flow in the penis, resulting in erection [ 3 , 4 ]. VAR has a comparable but slightly prolonged duration of pharmacological effect with regards to sildenafil—the first PDE-5 inhibitor used to treat erectile dysfunction.…”