Dual-radioisotope PET data acquisition and analysis

Miyaoka, Robert S.; Andreyev, Andriy; Pierce, Larry A.; Lewellen, T.K.; Celler, Anna; Kinahan, Paul E.

doi:10.1109/nssmic.2011.6153715

Cited by 9 publications

(17 citation statements)

References 16 publications

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“…A method using the difference in tracer decay times is not actually simultaneous multiple‐tracer imaging because all such methods either assume a static tracer distribution or estimate the tracer dynamics based on pharmacokinetics . On the other hand, a method that detect prompt γ ‐rays, a multi‐isotope PET (MI‐PET), is genuine simultaneous multiple‐tracer imaging and has recently been actively studied . A method using MI‐PET combined with the administration of two tracers at different times to increase the imaging performance has also been proposed by Andreyev et al .…”

Section: Introductionmentioning

confidence: 99%

“…In the MI‐PET method, the PET detector itself works as the prompt γ ‐ray detector; however, employing additional detectors enhances the detection efficiency . To demonstrate MI‐PET's feasibility, we developed a prototype MI‐PET system that is composed of a conventional circular ring PET and additional detectors to detect prompt γ ‐rays.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 On the other hand, a method that detect prompt c-rays, a multiisotope PET (MI-PET), is genuine simultaneous multiple-tracer imaging and has recently been actively studied. [3][4][5][6] A method using MI-PET combined with the administration of two tracers at different times to increase the imaging performance has also been proposed by Andreyev et al 7 In addition to the development of a MI-PET scanner, the production of specific radionuclides for MI-PET has also been investigated. 8 SPECT also works for multiple-tracer imaging based on c-ray energy separation.…”

Section: Introductionmentioning

confidence: 99%

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Positron emission tomography with additional γ -ray detectors for multiple-tracer imaging

Fukuchi¹,

Okauchi²,

Shigeta³

et al. 2017

Med. Phys.

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Purpose: Positron emission tomography (PET) is a useful imaging modality that quantifies the physiological distributions of radiolabeled tracers in vivo in humans and animals. However, this technique is unsuitable for multiple-tracer imaging because the annihilation photons used for PET imaging have a fixed energy regardless of the selection of the radionuclide tracer. This study developed a multiisotope PET (MI-PET) system and evaluated its imaging performance. Methods: Our MI-PET system is composed of a PET system and additional c-ray detectors. The PET system consists of pixelized gadolinium orthosilicate (GSO) scintillation detectors and has a ring geometry that is 95 mm in diameter with an axial field of view of 37.5 mm. The additional detectors are eight bismuth germanium oxide (BGO) scintillation detectors, each of which is 50 9 50 9 30 mm 3 , arranged into two rings mounted on each side of the PET ring with a 92-mminner diameter. This system can distinguish between different tracers using the additional c-ray detectors to observe prompt c-rays, which are emitted after positron emission and have an energy intrinsic to each radionuclide. Our system can simultaneously acquire double-(two annihilation photons) and triple-(two annihilation photons and a prompt c-ray) coincidence events. The system's efficiency for detecting prompt de-excitation c-rays was measured using a positron-c emitter, 22 Na. Dual-radionuclide ( 18 F and 22 Na) imaging of a rod phantom and a mouse was performed to demonstrate the performance of the developed system. Our system's basic performance was evaluated by reconstructing two images, one containing both tracers and the other containing just the second tracer, from list-mode data sets that were categorized by the presence or absence of the prompt c-ray. Results: The maximum detection efficiency for 1275 keV c-rays emitted from 22 Na was approximately 7% at the scanner's center, and the minimum detection efficiency was 5.1% at the edge of the field of view. Dual-radionuclide imaging of the point sources and rod phantom revealed that our system maintained PET's intrinsic spatial resolution and quantitative nature for the second tracer. We also successfully acquired simultaneous double-and triple-coincidence events from a mouse containing 18 F-fluoro-deoxyglucose and 22 Na dissolved in water. The dual-tracer distributions in the mouse obtained by our MI-PET were reasonable from the viewpoints of physiology and pharmacokinetics. Conclusions: This study demonstrates the feasibility of multiple-tracer imaging using PET with additional c-ray detectors. This method holds promise for enabling the reconstruction of quantitative multiple-tracer images and could be very useful for analyzing multiple-molecular dynamics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Positron emission tomography with additional γ -ray detectors for multiple-tracer imaging

Fukuchi¹,

Okauchi²,

Shigeta³

et al. 2017

Med. Phys.

View full text Add to dashboard Cite

show abstract

“…Then, by labeling two compounds, one with a pure positron emitter and the other with a complex-decay isotope, simultaneous multitracer imaging can be done (Figure 8) without losing sensitivity or image quality. Because this method does not require specialized detectors or additional energy-resolution requirements, it is being explored for implementation on clinical scanners (97). Simultaneously imaging several molecular or physiological targets using different radiotracers may provide valuable prognostic information and improve disease diagnosis and classification.…”

Section: Application Developmentsmentioning

confidence: 99%

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Vaquero

Kinahan

2015

Annu. Rev. Biomed. Eng.

286

183

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Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.

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“…Related approaches are also being studied for tracer pairs where one tracer emits a prompt high energy gamma in conjunction with the positron emission, facilitating differentiation of the tracers via triple-coincidence detection of the prompt gamma along with the positron annihilation photons. Several abstracts were presented at this meeting studying such approaches [13][14][15].…”

mentioning

confidence: 99%

Initial investigation of single-scan FDG+FLT PET tumor imaging techniques

Kadrmas

Oktay

2011

2011 IEEE Nuclear Science Symposium Conference Record

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Rapid multi-tracer PET aims to image two or more tracers in a single scan, thereby characterizing multiple aspects of function. Using dynamic imaging with tracers staggered in time, constraints on the kinetic behavior of each tracer can be applied to predict the makeup of the multi-tracer PET signal. Signal-separation algorithms can then be applied to recover estimates of each individual tracer. The effectiveness of the approach depends critically upon the tracers used, their kinetic behavior, the injection timing, and dynamic scanning protocol. A key question is what imaging endpoints (e.g. static images, SUVs, kinetic macroparameters or individual rate parameters) can be reliably recovered for each tracer. The ability to rapidly and reliably image both 18 F-fluorodeoxyglucose (FDG) and 18 F _ fluorothymidine (FL T) is of great interest, as characterization of tumor metabolism and proliferative activity provides complementary and relevant information for oncologic treatment decisions. However, it also provides one of the most challenging signal-separation problems for single-scan multi-tracer PET since both tracers are labeled with relatively long-lived 18 F, differences in radioactive decay cannot be utilized to aid in the multi-tracer signal-separation process. This work presents initial investigations into rapid dual-tracer FDG+FL T tumor imaging, characterizing the feasibility and main technological limitations of the approach. Simulation studies show that longer injection delays provided better signal-separation of the single-tracer measures, and markedly better performance was observed when FL T was administered first. Injection delays of approx. 30minled to good recovery (R>O.93) of SUVs, Kneb and K 1 ; however, recovery of higher-order rate parameters (k2' k3) was poor (R=O.5-0.6 at 30min delay), indicating that information regarding those parameters was effectively lost by the rapid dual-tracer technique.

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Dual-radioisotope PET data acquisition and analysis

Cited by 9 publications

References 16 publications

Positron emission tomography with additional γ -ray detectors for multiple-tracer imaging

Positron emission tomography with additional γ -ray detectors for multiple-tracer imaging

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Initial investigation of single-scan FDG+FLT PET tumor imaging techniques

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