Dual-reactive nanogels for orthogonal functionalization of hydrophilic shell and amphiphilic network

Abstract

Dual-reactive precursor nanogels allow independent adjustment of core and shell properties. This versatile synthetic platform is based on post-polymerization modification to give access to multi-functional nanogels.

Optically monitoring the microenvironment of a hydrophobic cargo in amphiphilic nanogels: influence of network composition on loading and release

“…Thereby, different hydrophobic and hydrophilic groups can be introduced into the network starting from one batch of poly( pentafluorophenyl methacrylate) (PPFPMA) precursor particles. 34 For the intended systematic study with NR, we used this strategy to prepare a library of ANGs with varying network amphiphilicity by functionalizing the reactive PPFPMA precursor particles with 80 mol% of hydrophilic 2-hydroxypropyl amine (HPA) and 20 mol% of different hydrophobic groups (ESI, Fig. S1a †).…”

“…The reactive precursor particles were synthesized using a free-radical emulsion polymerization approach, following a previously reported procedure with modifications. 33,34 Briefly, 15.00 g PFPMA (59.4 mmol, 1.0 eq.) and 0.236 g EGDMA (1.19 mmol, 0.02 eq.)…”

Rational Design and Development of Polymeric Nanogels as Protein Carriers

“…However, miniemulsions are thermodynamically unstable systems which require high shear forces to maintain the stability, and usually lead to broad PSDs. [31] Microemulsions are thermodynamically stable, however, they are only formed for a very specific ratio of monomer, solvent, and surfactants, which limits their versatility. [32] Precipitation polymerization is mostly used for temperaturesensitive systems, where the monomer is solubilized in the solvent (frequently water), but precipitates upon polymerization.…”

“…However, miniemulsions are thermodynamically unstable systems which require high shear forces to maintain the stability, and usually lead to broad PSDs. [ 31 ] Microemulsions are thermodynamically stable, however, they are only formed for a very specific ratio of monomer, solvent, and surfactants, which limits their versatility. [ 32 ]…”

Poly(N-acryloylmorpholine) Nanogels as Promising Materials for Biomedical Applications: Low Protein Adhesion and High Colloidal Stability

“…Hydrophilic polymer nanogels (NGs) are soft colloidal materials that combine the properties of hydrogels and nanoparticles in a unique way. By varying the structure and chemical composition of the internal polymer network, it is possible to control the NG’s amphiphilicity, , diffusion properties, responsiveness, and degradability . In biomedical applications, this allows tailoring of the NG's properties to very specific needs. , For example, as carriers in drug delivery, their internal structure can be optimized toward drug encapsulation and fine-tuning of specific triggered drug release profiles. − In addition, their external surface also has a large influence on their interactions with biological systems.…”