Dual release kinetics of antimalarials from soy protein isolate‐carbopol‐polyacrylamide based hydrogels

Abstract

The currently used antimalarials suffer from drug resistance which is hampering the global management of malaria infection. To overcome drug resistance, they are administered as combination therapies which involve combination of two or more antimalarials. In this study, chloroquine diphosphate and curcumin were encapsulated onto prepared soy protein isolate-carbopol-polyacrylamide based hydrogels. The hydrogels were pH sensitive and exhibited enhanced swelling capability at pH 7.4. The hydrogels were biodegradable which was observed by their SEM images after drug release. The release mechanisms of both drugs were influenced by the degree of crosslinking of the soy protein isolate in the hydrogel network and the presence of the other drug in the network. The release mechanisms of both drugs from the hydrogel networks followed super case transport II. These results suggested that the hydrogels were potential dual drug delivery systems for antimalarials whereby both drugs could work over different period of time and hence, have the potential to overcome drug resistance that is common with the presently used antimalarials. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43918.

Biodegradable pH-responsive hydrogels for controlled dual-drug release

“…34 pH sensitive protein-carbopolpolyacrylamide based hydrogels have been used to encapsulate a combination of antimalarial drugs (one highly water soluble and the other highly insoluble) with the hydrogel allowing controlled delivery/release of both drugs. 40 Here hydrogels were designed to act as pH responsive ''smart drug carriers'' to allow controlled dual drug release, with materials fabricated using poly(L-lactide)-co-polyethyleneglycol-co-poly(L-lactide) dimethacrylates (MA-PLLA-PEG-PLLA-MA) as degradable polymeric crosslinkers along with the monomers acrylic acid (AA) and N-isopropylacrylamide (NIPAM). As model compounds the anticancer drug DOX and the antibiotic tetracycline (TET) 41,42 were loaded into the hydrogels with the dual drug loading efficiency and in vitro drug release at pH 7.4 and 1.2 examined.…”

Polymeric Nanocarriers for the Delivery of Antimalarials

“…These results suggest that the formulation is a potential adjunct anti-malarial therapy that can be used along with standard therapy. The formulation was not toxic and it was found to be suitable for a prolonged duration [ 34 ]. Aderibigbe and Mhlwatika prepared soy protein isolates–carbopol–polyacrylamide-based gels encapsulated with chloroquine diphosphate and curcumin ( Table 1 ).…”

Cytotoxicity and in vitro evaluation of whey protein-based hydrogels for diabetes mellitus treatment

“…As a result of challenges with targeting causative substances using single drug molecules, combination of different drugs has been administered optimally and at different periods of the treatment [17][18][19]. Until recently, limited researches on dual drug delivery systems have so far provided positive results [5,[20][21][22].…”